Surface-Functionalized NdVO4:Gd3+ Nanoplates as Active Agents for Near-Infrared-Light-Triggered and Multimodal-Imaging-Guided Photothermal Therapy

Abstract

Development of nanotheranostic agents with near-infrared (NIR) absorption offers an effective tool for fighting malignant diseases. Lanthanide ion neodymium (Nd3+)-based nanomaterials, due to the maximum absorption at around 800 nm and unique optical properties, have caught great attention as potential agents for simultaneous cancer diagnosis and therapy. Herein, we employed an active nanoplatform based on gadolinium-ion-doped NdVO4 nanoplates (NdVO4:Gd3+ NPs) for multiple-imaging-assisted photothermal therapy. These NPs exhibited enhanced NIR absorption and excellent biocompatibility after being grafted with polydopamine (pDA) and bovine serum albumin (BSA) layers on their surface. Upon expose to an 808 nm laser, these resulting NPs were able to trigger hyperthermia rapidly and cause photo-destruction of cancer cells. In a xenograft tumor model, tumor growth was also significantly inhibited by these photothermal agents under NIR laser irradiation. Owing to the multicomponent nanostructures, we demonstrated these nanoagents as being novel contrast agents for in vivo magnetic resonance (MR) imaging, X-ray computed tomography (CT), photoacoustic (PA) imaging, and second biological window fluorescent imaging of tumor models. Thus, we believe that this new kind of nanotherapeutic will benefit the development of emerging nanosystems for biological imaging and cancer therapy.

Development of novel polymeric nanoagents and their potential in cancer diagnosis and therapy runing title: Polymeric nanoagents for cancer theranostics

“…These features have allowed polymeric nanoagents to perform specific imaging and precise therapy of cancer tissues, further developing into personalized polymeric theranostic nanoplatforms. Compared to conventional imaging methods, novel polymeric nanoagentsbased imaging has a high temporospatial resolution, and numerous polymeric nanoagents have been developed for the early detection of cancer, such as indocyanine green (ICG) (Lv et al, 2022), lanthanide ion neodymium (Nd) (Deng et al, 2022), and chlorin e6 (Ce6)-based nanoagents (Odda et al, 2020).…”

Methylene Blue-Loaded Mesoporous Silica-Coated Gold Nanorods on Graphene Oxide for Synergistic Photothermal and Photodynamic Therapy

“…As emerging phototherapeutic strategies, photothermal therapy (PTT) and photodynamic therapy (PDT) have attracted increasing clinical attention in recent years, which is beneficial for enhanced cancer therapy because of their synergistic effects [ 6 ]. PTT has attracted considerable interest in cancer treatment because of its minimal invasiveness, high efficiency, low toxicity, and deep tissue penetration [ 7 , 8 ]. In PTT, a photothermal nanoagent directly converts the absorbed NIR light into heat-to-kill cancer cells [ 9 ].…”

A Local Water Molecular-heating Strategy for NIR Long-lifetime Imaging-guided Photothermal Therapy of Deep-tissue-bearing Tumor

“…Particularly, Yb-Tm co-doped NaYF 4 has been extensively studied because near-infrared (NIR) light is more suitable for bioimaging applications instead of visible regions 1,2,3 . Recently, as emerging theranostic nanoparticles (NPs), neodymium (Nd)-doped NPs, such as NaNdF 4 , LaF 3 :Nd 3+ , and NdVO 4 materials, have featured good photostability and multifunctionality for the imaging-guided photothermal therapies (PTT) 4,5,6,7 . These NPs generate heat by cross-relaxation (CR), a phenomenon that occurs between Nd 3+ ions themselves or other neighboring ions in ladder-like energy states.…”