A coating that can be activated by
moisture found in
respiratory
droplets could be a convenient and effective way to control the spread
of airborne pathogens and reduce fomite transmission. Here, the ability
of a novel 6-hydroxycatechol-containing polymer to function as a self-disinfecting
coating on the surface of polypropylene (PP) fabric was explored.
Catechol is the main adhesive molecule found in mussel adhesive proteins.
Molecular oxygen found in an aqueous solution can oxidize catechol
and generate a known disinfectant, hydrogen peroxide (H2O2), as a byproduct. However, given the limited amount
of moisture found in respiratory droplets, there is a need to enhance
the rate of catechol autoxidation to generate antipathogenic levels
of H2O2. 6-Hydroxycatechol contains an electron
donating hydroxyl group on the 6-position of the benzene ring, which
makes catechol more susceptible to autoxidation. 6-Hydroxycatechol-coated
PP generated over 3000 μM of H2O2 within
1 h when hydrated with a small amount of aqueous solution (100 μL
of PBS). The generated H2O2 was three orders
of magnitude higher when compared to the amount generated by unmodified
catechol. 6-Hydroxycatechol-containing coating demonstrated a more
effective antimicrobial effect against both Gram-positive (Staphylococcus aureus and Staphylococcus
epidermidis) and Gram-negative (Pseudomonas
aeruginosa and Escherichia coli) bacteria when compared to unmodified catechol. Similarly, the self-disinfecting
coating reduced the infectivity of both bovine viral diarrhea virus
and human coronavirus 229E by as much as a 2.5 log reduction value
(a 99.7% reduction in viral load). Coatings containing unmodified
catechol did not generate sufficient H2O2 to
demonstrate significant virucidal effects. 6-Hydroxycatechol-containing
coating can potentially function as a self-disinfecting coating that
can be activated by the moisture present in respiratory droplets to
generate H2O2 for disinfecting a broad range
of pathogens.