Surface functional polymer library by post-polymerisation modification using diarylmethylenes: metal ligand catch and release

Antibacterial Drug Releasing Materials by Post-Polymerization Surface Modification

“…9,14,34 Bioassay method 8 : Samples of modi¯ed beads (30 mg) were mixed with 90 mg of blank beads to give a four-fold dilution. Six sets of beads (10 mg each) were prepared for the hole-plate bioassay; of these six sets, three sets were used for S.aureus plates as triplicate, and three sets were for testing with E.coli plates in triplicate.…”

“…has been reported (but also see ESI for relevant data) 9,14,34 Reaction of this modi¯ed polymer with the known iodides 5a,b 28,35 then gave the spirocyanine materials 6a,b. The presence of the spiropyran unit on the surface was con¯rmed from the presence of nitro groups in the ATR-IR spectrum of 6a (1510 cm À1 ), and bromo groups in the combustion analysis and XPS spectrum of 6b (see ESI); estimation of the surface loading data from the combustion analysis gave densities of 6:7 Â 10 12 , 5:0 Â 10 12 , 2:7 Â 10 12 and 2:6 Â 10 12 molecules.…”

“…In one approach, by exploiting the well-known reactivity of carbenes with both and chemical bonds for insertion and addition processes respectively, the functionalization of both reactive (organic and inorganic polymers) and inert (diamond, nanotubes, hydrocarbon polymers) materials using diaryldiazomethanes 1 to introduce varied surface properties, [2][3][4] including chromophoric, 5 protein a±nity, 6,7 biocidal, 8 chelation, 9 biocompatibility, 10 payload delivery, 11 dispersability, 12 nano¯lling, 13 and wettability 14,15 e®ects has been achieved. Of interest, however, was whether the surface loading density which could be achieved using this approach, which was generally in the range 0.01-0.2 mmol/g, [2][3][4] was su±cient to permit the reversible binding of small molecules at a level which was both detectable and had the capacity for a therapeutic e®ect; that this might be possible which was suggested from earlier work in which the binding of hydrogen peroxide was shown to lead to bactericidal properties, a result which was considered likely to be a best case scenario, since the existence of an extensive hydrogen binding network appeared to support multiple hydrogen peroxide units per unit of introduced surface urea groups giving high overall surface loading.…”

Self‐healing polyurethane nanocomposite films with recoverable surface hydrophobicity

“…First, several furan‐based monomers were synthesized to prepare polyurethanes, which were subsequently crosslinked with maleimides through the typical DA/rDA reaction. Secondly, perfluoroalkyl diazomethane was synthesized and introduced onto the surface of SiO 2 nanoparticles by carbene insertion approach, which was proved by us to be a short synthetic route with mild reaction conditions, and could be further used to introduce color, fluorescence, biocompatibility, and biocidal properties . Finally, polymer nanocomposite films were prepared by mixing modified SiO 2 nanoparticles with self‐healing polyurethanes, followed by the characterization of their mechanical property and surface performance.…”

Preparation, Post‐Modification, and Antibacterial Application of Gelatin Electrospun Membranes

“…In this work, a gelatin membrane, prepared by electrospinning in order to generate a porous structure, was surface modified with two bis(diaryldiazomethane)s. This modified gelatin membrane was a further example of the carbene modification of natural polymers, which had already been applied for the modification of color, hydrophobicity, biocompatibility, protein binding and adsorption, and payload delivery effects on various surfaces. The subsequent cross‐linking reaction between the end‐group amines and diisocyanates gave a structurally robust surface, which was expected to bind hydrogen peroxide and largely endowed with the antibacterial activity.…”