Surface fabrication of magnetic core-shell silica nanoparticles with perylene diimide as a fluorescent dye for nucleic acid visualization

Ali, Tammar Hussein; Mandal, Amar Mousa; Alhasan, Ammar; Dehaen, Wim

doi:10.1016/j.molliq.2022.119345

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…Polycyclic aromatic hydrocarbons (PAHs), such as naphthalene, anthracene, pyrene, and perylene, are excellent rigid molecular skeletons that are useful for developing highly efficient two-photon excitable fluorescent probes. Ali et al designed an innovative fluorescent dye by impregnating perylene diimide into the functionalized surface of magnetic core–shell silica nanoparticles [ 45 ]. These nanoparticles exhibit features such as low toxicity, being environmentally friendly, and high sensitivity; they also show high DNA binding capacity, which makes the developed particle promising for DNA extraction, delivery, and fluorescent labeling.…”

Section: Design Of Molecular Probes For Organelle-targeted Cell Imagingmentioning

confidence: 99%

Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging

Dai

Cui

et al. 2023

Biosensors

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Fluorescent molecular probes are very powerful tools that have been generally applied in cell imaging in the research fields of biology, pathology, pharmacology, biochemistry, and medical science. In the last couple of decades, numerous molecular probes endowed with high specificity to particular organelles have been designed to illustrate intracellular images in more detail at the subcellular level. Nowadays, the development of cell biology has enabled the investigation process to go deeply into cells, even at the molecular level. Therefore, probes that can sketch a particular organelle’s location while responding to certain parameters to evaluate intracellular bioprocesses are under urgent demand. It is significant to understand the basic ideas of organelle properties, as well as the vital substances related to each unique organelle, for the design of probes with high specificity and efficiency. In this review, we summarize representative multifunctional fluorescent molecular probes developed in the last decade. We focus on probes that can specially target nuclei, mitochondria, endoplasmic reticulums, and lysosomes. In each section, we first briefly introduce the significance and properties of different organelles. We then discuss how probes are designed to make them highly organelle-specific. Finally, we also consider how probes are constructed to endow them with additional functions to recognize particular physical/chemical signals of targeted organelles. Moreover, a perspective on the challenges in future applications of highly specific molecular probes in cell imaging is also proposed. We hope that this review can provide researchers with additional conceptual information about developing probes for cell imaging, assisting scientists interested in molecular biology, cell biology, and biochemistry to accelerate their scientific studies.

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Section: Design Of Molecular Probes For Organelle-targeted Cell Imagingmentioning

confidence: 99%

Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging

Dai

Cui

et al. 2023

Biosensors

View full text Add to dashboard Cite

show abstract

“…Nonetheless, significant efforts have recently focused on developing inorganic composite sensors or probes by incorporating various PDIs, although these sensors were designed primarily for bioimaging or monitoring of other analytes [38,39]. The common way to fabricate inorganic composite sensors of PDI would be via the functionalization or blending of PDI with organic [40], inorganic [41][42][43] or organic-inorganic [44][45][46][47][48][49] counterparts in the form of conjugates or nanoparticles, which are conducive to development of fluorescence bioimaging, NIR-absorbing photosensitizers for photodynamic therapy and environmental or health monitoring [50]. Surface immobilization of PDIs on inorganic nanoparticles, such as silica gels [51,52] and single-walled carbon nanotubes (SWCNTs) [53], has also been reported for fluorescent or colorimetric sensing.…”

Section: Ph Response With Pdi-involved Compositesmentioning

confidence: 99%

Architectures and Mechanisms of Perylene Diimide-Based Optical Chemosensors for pH Probing

et al. 2023

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The precise control and monitoring of pH values remain critical for many chemical, physiological and biological processes. Perylene diimide (PDI)-based molecules and materials exhibit excellent thermal, chemical and photochemical stability, unique UV-vis absorption and fluorescent emission properties, low cytotoxicity, as well as intrinsic electron-withdrawing (n-type semiconductor) nature and impressive molecular assembly capability. These features combined enable promising applications of PDIs in chemosensors via optical signal modulations (e.g., fluorescent or colorimetric). One of the typical applications lies in the probing of pH under various conditions, which in turn helps monitor the extracellular (environmental) and intracellular pH change and pH-relying molecular recognition of inorganic or organic ions, as well as biological species, and so on. In this review, we give a special overview of the recent progress in PDI-based optical chemosensors for pH probing in various aqueous and binary water–organic media. Specific emphasis will be given to the key design roles of sensing materials regarding the architectures and the corresponding sensing mechanisms for a sensitive and selective pH response. The molecular design of PDIs and structural optimization of their assemblies in order to be suitable for sensing various pH ranges as applied in diverse scenarios will be discussed in detail. Moreover, the future perspective will be discussed, focusing on the current key challenges of PDI-based chemosensors in pH monitoring and the potential approach of new research, which may help address the challenges.

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Surface fabrication of magnetic core-shell silica nanoparticles with perylene diimide as a fluorescent dye for nucleic acid visualization

Cited by 2 publications

References 59 publications

Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging

Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging

Architectures and Mechanisms of Perylene Diimide-Based Optical Chemosensors for pH Probing

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