Surface-enhanced vibrational investigation of adsorbed analgesics

Smith, Merritt; Stambaugh, Kaitlyn; Smith, Lauren G.; Son, Hye-Jin; Gardner, Amanda; Cordova, Scott; Posey, Krystal; Perry, Donald A.; Biris, Alexandru S.

doi:10.1016/j.vibspec.2008.11.002

Cited by 28 publications

(29 citation statements)

References 43 publications

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“…4. This observation supports our previous work emphasizing the similarities between the silver powder and silver films [12,13]. There are, nevertheless, a few fundamental differences between the spectra.…”

Section: Resultssupporting

confidence: 91%

“…4 spare the absence of a small band in the 1700 cm À1 (only seen with n-pentane) that will be addressed shortly. We have previously documented the impact of bond polarity of the deposition solvent in other systems and attribute the differences between adsorption using solvents with polar versus nonpolar bonds to the degree of adsorbate solvation [12,13].…”

Section: Resultsmentioning

confidence: 99%

“…Silver nanostructures typically yield the best vibrational enhancement in SERS and SEIRA, but gold nanostructures are often used because of silver's strong propensity for oxidation and coagulation while in a nanostructural form [7]. SERS has been shown to be most sensitive to the first adsorbed monolayer while enhancement of both the monolayer and multilayer is frequently observed with SEIRA [11][12][13]. It is now common and convenient to take advantage of SEIRA and SERS approaches to study the adsorbate interactions with metal nanostructures due to the vibrational enhancement inherent to their interaction with many metal nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…More research is being performed where the combination of SERS and SEIRA is used to investigate a given system [11][12][13][14][15][16][17][18][19][20][21][22][23]. Additionally, SEIRA has been used in several circumstances to characterize the adsorption of a complete set of aromatic isomers with two substituents [11,13,14,24,25].…”

Section: Introductionmentioning

confidence: 99%

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Adsorption analysis of nitrophenol isomers on silver nanostructures by surface-enhanced spectroscopy

Perry

Son

Cordova

et al. 2010

Journal of Colloid and Interface Science

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adsorption analysis of nitrophenol isomers on silver nanostructures by surface-enhanced spectroscopy

Perry

Son

Cordova

et al. 2010

Journal of Colloid and Interface Science

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“…Surface-enhanced vibrational spectroscopic techniques, namely surface-enhanced Raman scattering (SERS) spectroscopy [1][2][3] and surface-enhanced infrared absorption (SEIRA) spectroscopy [4,5], are frequently used in spectroscopic laboratories for the detection of pharmaceuticals and biologically active compounds owing to their ability to detect trace amounts of analytes [6][7][8][9][10][11][12][13][14]. Spectra obtained using surface-enhanced spectroscopic techniques are also useful in the investigation of the adsorption mechanisms for different kinds of molecules located on metal surfaces [4,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Surface-enhanced vibrational spectroscopy of B vitamins: what is the effect of SERS-active metals used?

Kokaislova

Matějka

2012

Anal Bioanal Chem

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Surface-enhanced Raman scattering (SERS) spectroscopy and surface-enhanced infrared absorption (SEIRA) spectroscopy are analytical tools suitable for the detection of small amounts of various analytes adsorbed on metal surfaces. During recent years, these two spectroscopic methods have become increasingly important in the investigation of adsorption of biomolecules and pharmaceuticals on nanostructured metal surfaces. In this work, the adsorption of B-group vitamins pyridoxine, nicotinic acid, folic acid and riboflavin at electrochemically prepared gold and silver substrates was investigated using Fourier transform SERS spectroscopy at an excitation wavelength of 1,064 nm. Gold and silver substrates were prepared by cathodic reduction on massive platinum targets. In the case of gold substrates, oxidation-reduction cycles were applied to increase the enhancement factor of the gold surface. The SERS spectra of riboflavin, nicotinic acid, folic acid and pyridoxine adsorbed on silver substrates differ significantly from SERS spectra of these B-group vitamins adsorbed on gold substrates. The analysis of near-infrared-excited SERS spectra reveals that each of B-group vitamin investigated interacts with the gold surface via a different mechanism of adsorption to that with the silver surface. In the case of riboflavin adsorbed on silver substrate, the interpretation of surface-enhanced infrared absorption (SEIRA) spectra was also helpful in investigation of the adsorption mechanism.

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SERS and Pharmaceuticals

Pinzaru¹,

Pavel²

2010

Surface Enhanced Raman Spectroscopy

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IntroductionDevelopments in the pharmaceutical industry are nowadays driven by the requirement for high efficacy while retaining reduced side effects. For this reason, new medicines are very often of relatively low dose, typically less than 100 mg of drug substance (i.e. less than 10% w/w) in a tablet. This poses major analytical challenges with respect to the rapid chemical identification of active drug substances, their polymorphic forms, possible contaminants, the distribution and interaction between drug substances and excipients, and so on. Drug and excipient particle sizes can vary, but they are generally of micron size, thus resulting in dosage samples that have substance inhomogeneity on a similar scale. Therefore, the analysis of such dosage samples by conventional techniques such as mass spectrometry, elemental analysis, spectrophotometry or nuclear magnetic resonance (NMR) can be very difficult.With the advent of new instrumentation and intense monochromatic light sources, Raman spectroscopy has become a popular tool for analysing pharmaceutical compounds [1, 2]. However, a major problem with the analysis of pharmaceutical compounds by Raman spectroscopy is the weak intensity of the Raman scattered signal and the fluorescence caused by either the active drug itself or by a small amount of impurity present in the sample. The fluorescence emission of aromatic molecules generally occurs in the near-UV to visible spectral region. Therefore, it can interfere with the Raman signal if it is located within that spectral region. This problem can be circumvented if Raman scattering is excited in the UV or near-infrared (NIR) region of the electromagnetic spectrum, by choosing a laser of appropriate wavelength (e.g. a UV or NIR laser). Moreover, the NIR laser photon does not have enough energy to excite the fluorophore by single-photon excitation. This results in a reduced fluorescence emission. On the other hand, excitation with a UV laser still produces fluorescence, but the Raman spectrum is positioned in the relatively fluorescence-free UV region of the electromagnetic spectrum [3]. However, there are two major disadvantages associated with NIR excitation. The Raman intensity is inversely proportional to the fourth power of

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Surface-enhanced vibrational investigation of adsorbed analgesics

Cited by 28 publications

References 43 publications

Adsorption analysis of nitrophenol isomers on silver nanostructures by surface-enhanced spectroscopy

Adsorption analysis of nitrophenol isomers on silver nanostructures by surface-enhanced spectroscopy

Surface-enhanced vibrational spectroscopy of B vitamins: what is the effect of SERS-active metals used?

SERS and Pharmaceuticals

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