Surface-enhanced Raman spectroscopy: substrate-related issues

Lin, Xiuzhu; Cui, Yan; Xu, Yanhui; Ren, Bin; Zhang, Tian

doi:10.1007/s00216-009-2761-5

Cited by 564 publications

(479 citation statements)

References 112 publications

Supporting

Mentioning

456

Contrasting

Unclassified

Order By: Relevance

“…The main properties that SERS substrates should show are high sensitivity, uniformity, good stability, surface purity and reproducibility. 9,10 Although it is quite complicated to obtain substrates with all these properties, metal (Au, Ag, Pd, Pt,…) nanoparticles (NPs) are systems largely employed in SERS. [11][12][13][14][15] In particular, gold deposition by plating processes provides SERS substrates with the long term stability and high enhanced factor.…”

Section: Introductionmentioning

confidence: 99%

Study of Adenine and Guanine Oxidation Mechanism by Surface-Enhanced Raman Spectroelectrochemistry

et al. 2015

View full text Add to dashboard Cite

Metal nanoparticles are systems largely employed in surface-enhanced Raman spectroscopy (SERS). In particular, gold nanoparticles are one of the best substrates used in this field. In this work, the optimal conditions for gold nanoparticles electrodeposition on single-walled carbon nanotubes electrodes have been established to obtain the best SERS response. Using this substrate and analyzing the changes of in-situ Raman spectra obtained at different potentials, we have been able to explain simultaneously the oxidation mechanism of purine bases, differentiating the oxidation intermediates, and their orientation during the different oxidation steps. Adenine orientation hardly changes during the whole oxidation; the molecule maintains a parallel configuration and only shows a slightly tilted orientation after the first oxidation step.On the other hand, guanine orientation changes completely during its oxidation.Initially, guanine is perpendicular respect to gold nanoparticles, changing its orientation after the first oxidation process when the molecule shows a slightly tilted orientation and it finishes parallel respect to the electrode surface after the second oxidation step.

show abstract

Section: Introductionmentioning

confidence: 99%

Study of Adenine and Guanine Oxidation Mechanism by Surface-Enhanced Raman Spectroelectrochemistry

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Thus, the SERS signal is sometimes too sensitive to a SERS substrate, possible fluctuations caused by nonuniform molecular adsorption (amounts/configurations), different metal enhancers and the corresponding metal-molecule interactions bring down the comparability between parallel SERS experiments, and as a result standard analytical methods based on SERS have been rarely popularized. To further understand the SERS effect and fully excite its advanced applications, a SERS substrate with a more "intelligent" form is still lacking.From the above, the availability of an enhancement substrate, which can give a uniform, stable, clean and highly sensitive SERS response has remained a bottleneck for extending the further applications of SERS (10,14). Current efforts towards more reproducible SERS analyses are mainly focused on the nanotailoring or nanoassembly of substrates with uniform metal nanostructure arrays (15-19).…”

mentioning

confidence: 99%

“…From the above, the availability of an enhancement substrate, which can give a uniform, stable, clean and highly sensitive SERS response has remained a bottleneck for extending the further applications of SERS (10,14). Current efforts towards more reproducible SERS analyses are mainly focused on the nanotailoring or nanoassembly of substrates with uniform metal nanostructure arrays (15)(16)(17)(18)(19).…”

mentioning

confidence: 99%

Surface enhanced Raman spectroscopy on a flat graphene surface

Ling

Xiao

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

522

484

View full text Add to dashboard Cite

Surface enhanced Raman spectroscopy (SERS) is an attractive analytical technique, which enables single-molecule sensitive detection and provides its special chemical fingerprints. During the past decades, researchers have made great efforts towards an ideal SERS substrate, mainly including pioneering works on the preparation of uniform metal nanostructure arrays by various nanoassembly and nanotailoring methods, which give better uniformity and reproducibility. Recently, nanoparticles coated with an inert shell were used to make the enhanced Raman signals cleaner. By depositing SERS-active metal nanoislands on an atomically flat graphene layer, here we designed a new kind of SERS substrate referred to as a graphene-mediated SERS (G-SERS) substrate. In the graphene/ metal combined structure, the electromagnetic "hot" spots (which is the origin of a huge SERS enhancement) created by the gapped metal nanoislands through the localized surface plasmon resonance effect are supposed to pass through the monolayer graphene, resulting in an atomically flat hot surface for Raman enhancement. Signals from a G-SERS substrate were also demonstrated to have interesting advantages over normal SERS, in terms of cleaner vibrational information free from various metal-molecule interactions and being more stable against photo-induced damage, but with a comparable enhancement factor. Furthermore, we demonstrate the use of a freestanding, transparent and flexible "G-SERS tape" (consisting of a polymer-layer-supported monolayer graphene with sandwiched metal nanoislands) to enable direct, real time and reliable detection of trace amounts of analytes in various systems, which imparts high efficiency and universality of analyses with G-SERS substrates.atomically smooth substrate | metal-molecule isolation | signal fluctuation | mediator | application F or almost all sorts of analytical methods, the dream to improve their sensitivity as well as their reproducibility and to optimize the analytical process (e.g., to simplify the sample preparation/ measurement procedures for quick analysis and to enable in situ and real time monitoring) is a long-term pursuit. Spectroscopic approaches based on fluorescence, infrared absorption and Raman scattering have been developed with rising importance for various sensing and imaging applications. Among them, Raman scattering provides more structural information (characteristic vibrational information of each chemical bond) over fluorescence, and higher spatial resolution (shorter excitation wavelength) over infrared absorption (1). However, as Raman scattering is an inelastic scattering process with a very low crosssection, it is not very sensitive and thus has limited analysis efficiency and applicability.Because of this, surface enhanced Raman spectroscopy (SERS) has been developed since the 1970s (2-4) to enable ultrasensitive characterization down to the single-molecule level (5, 6), comparable to single-molecule fluorescence spectroscopy (7). In a SERS experiment, a rough metal surface or colloid...

show abstract

“…2(C)), silver nanoparticles started to aggregate together, and after adjusting the pH value, the colloidal was further aggregated, and the clusters became bigger. The inter-particle space of nanoparticles was then down to several nanometers, which is one feature of an ideal SERS substrate 30 (Fig. 2(D)).…”

Section: Resultsmentioning

confidence: 99%

Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering

Zhang¹,

Huang

Liu

et al. 2013

ANAL. SCI.

View full text Add to dashboard Cite

Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.

show abstract

Surface-enhanced Raman spectroscopy: substrate-related issues

Cited by 564 publications

References 112 publications

Study of Adenine and Guanine Oxidation Mechanism by Surface-Enhanced Raman Spectroelectrochemistry

Study of Adenine and Guanine Oxidation Mechanism by Surface-Enhanced Raman Spectroelectrochemistry

Surface enhanced Raman spectroscopy on a flat graphene surface

Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering

Contact Info

Product

Resources

About