Surface-Enhanced Raman Scattering Spectroscopic Study of 17.alpha.-Ethinylestradiol on Silver Colloid and in Glass-Deposited Ag-17.alpha.-Ethinylestradiol Film

Barnett, Steven M.; Vlčková, Blanka; Butler, Ian S.; Kanigan, Tanya S.

doi:10.1021/ac00082a026

Cited by 17 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[11][12][13][14] Currently, there are two separated mechanisms to describe the overall SERS effect: electromagnetic effect ͑EM͒ and chemical effect ͑CM͒. EM is regarded as a long-range effect, in which the localized electromagnetic field plays the most roles in SERS, [15][16][17][18] while CM is the interaction of the adsorbate adsorbed on the metal surface with the metal, such as the charge transfer of the adsorbate with the metal.…”

Section: Introductionmentioning

confidence: 99%

“…24 And in 1997, Nie and Emery reported single molecule detection ͑SMD͒ by SERS on single aggregated Ag NPs. 25 The SERS enhancement factors can reach as large as 10 14 . Such large enhancement factors may be derived from the electromagnetic field in which probe molecules reside in the junction of the two aggregated Ag NPs according to Michaels et al 26 All these reports enhance the interest of the metallic colloid system in SERS applications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surface enhanced Raman scattering of p-aminothiophenol self-assembled monolayers in sandwich structure fabricated on glass

Wang

Chen

Dong

et al. 2006

The Journal of Chemical Physics

107

View full text Add to dashboard Cite

A sandwich structure consisting of Ag nanoparticles (NPs), p-aminothiophenol (p-ATP) self-assembled monolayers (SAMs), and Ag NPs was fabricated on glass and characterized by surface enhanced Raman scattering (SERS). The SERS spectrum of a p-ATP SAM in such sandwich structure shows that the electromagnetic enhancement is greater than that on Ag NPs assembled on glass. The obtained enhancement factors (EF) on solely one sandwich structure were as large as 6.0±0.62×104 and 1.2±0.62×107 for the 7a and 3b(b2) vibration modes, respectively. The large enhancement effect of p-ATP SAMs is likely a result of plasmon coupling between the two layers of Ag NP (localized surface plasmon) resonance, creating a large localized electromagnetic field at their interface, where p-ATP resides. Moreover, the fact that large EF values (∼1.9±0.7×104 and 9.4±0.7×106 for the 7a- and b2-type vibration modes, respectively) were also obtained on a single sandwich structure of Au NPs∕p-ATPSAMs∕Ag NPs in the visible demonstrates that the electromagnetic coupling does not exist only between Ag NPs but also between Au and Ag NPs. The lower EF values on Au-to-Ag NPs compared to those on Ag-to-Ag NPs demonstrate that the Au-to-Ag coupling must be less effective than the Ag-to-Ag coupling for the induction of SERS in the visible.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface enhanced Raman scattering of p-aminothiophenol self-assembled monolayers in sandwich structure fabricated on glass

Wang

Chen

Dong

et al. 2006

The Journal of Chemical Physics

107

View full text Add to dashboard Cite

show abstract

“…It is known that the pyridyl ring of PySH is tilted with respect to the surface when it is adsorbed on a m etal surface. [37][38][39][40][41][42][43][44] There is not enough evidence to indicate that the pyridyl ring orientation changes upon the form ation of the TbOH-PySH composite lm.…”

Section: Resultsmentioning

confidence: 99%

Ultraviolet—Visible and Surface-Enhanced Raman Scattering Spectroscopy Studies on Self-Assembled Metalloporphyrin Films on Organic Monolayer-Modified Ultra-Thin Silver Substrates

Jia

et al. 2004

Appl Spectrosc

View full text Add to dashboard Cite

A self-assembled monolayer (SAM) film of 5,10,15,20-tetra-(para-chlorophenyl)-porphyrin terbium (or lutetium) hydroxy compound (TbOH/LuOH) fabricated on a silver substrate premodified with a SAM of 4-mercaptopyridine (PySH) was studied by ultraviolet-visible (UV-Vis) spectroscopy and surface-enhanced Raman scattering (SERS) spectroscopy. PySH can modify the substrate and deliver its pyridyl group pointing out from the silver surface. Thus, we can investigate the effects of the central metals of the metalloporphyrins in the formation of the composite films. For the TbOH-PySH composite film, a new absorption band arising from TbOH appears at 425 nm, and a band at 512 nm due to the PySH-modified silver substrate shifts to a longer wavelength (538 nm). The results suggest that TbOH is successfully assembled on the top of PySH-modified silver film and that there is an interaction between TbOH and PySH in the film. The frequency shifts and relative intensity changes of bands due to PySH in the SERS spectra imply the coordination of the pyridyl group on Tb in the SAM. As for the LuOH-PySH composite film, its SERS spectrum shows bands arising from both the LuOH and PySH moieties, indicating that LuOH is assembled on the PySH-modified silver film. Furthermore, a band at 1221 cm(-1) due to the in-plane C-H bending mode of PySH disappears, implying that the pyridyl moiety of PySH becomes more parallel to the silver surface upon the formation of the LuOH-PySH composite film. Additionally, an absorption band at 515 nm shifts to a longer wavelength (541 nm) and becomes broad upon the formation of the composite film, suggesting an interaction between LuOH and PySH in the film. By comparing the spectral changes between the two self-assembled composite films, we find that the central metal is crucial in the formation of the composite films. The structure and orientation of the composite films depend on the central metal of the metalloporphyrin compounds.

show abstract

“…7 Among these are studies using infrared (IR) and Raman spectroscopy to examine the structure of 17β-estradiol as well as several A-ring and 17α-ethynylestradiol derivatives. 8,9 Additionally, the role of the hydroxyl groups in the conformation of bare estradiol and the structures of its monohydrated clusters were monitored using IR-UV double resonance spectroscopy and density functional theory (DFT) calculations. 10 The less frequent use of Raman spectroscopy in the study of estrogens is due mainly to its inherently weak signals and the presence of fluorescence interference brought about by the fluorescent contaminants in most samples.…”

Section: Introductionmentioning

confidence: 99%

Raman spectroscopic discrimination of estrogens

Vedad

Mojica

Desamero

2018

Vibrational Spectroscopy

View full text Add to dashboard Cite

Estrogens are a group of steroid compounds found in the human body that are eventually discharged and ultimately end up in sewer effluents. Since these compounds can potentially affect the endocrine system its detection and quantification in sewer water is important. In this study, estrogens such as estrone (E1), estradiol (E2), estriol (E3), and ethynylestradiol (EE2) were discriminated and quantitated using Raman spectroscopy. Simulated Raman spectra were correlated with experimental data to identify unique marker peaks, which proved to be useful in differentiating each estrogen molecules. Among these marker peaks are Raman modes arising from hydroxyl groups of the estrogen molecules in the spectral region 3200–3700 cm−1. Other Raman modes unique to each of the estrogen samples were also identified, including peaks at 1722 cm−1 for E1 and 2109 cm−1 for EE2, which corresponds to their distinctive structures each containing a different set of functional groups. To quantify the components of estrogen mixtures, the intensities of each identifying Raman bands, at 581 cm−1 for E1, 546 cm−1 for E2, 762 cm−1 for E3 and 597 cm−1 for EE2, were compared and normalized against the intensity of a common peak at 783 cm−1. Quantitative analysis yielded most results within an acceptable 20% error.

show abstract

Surface-Enhanced Raman Scattering Spectroscopic Study of 17.alpha.-Ethinylestradiol on Silver Colloid and in Glass-Deposited Ag-17.alpha.-Ethinylestradiol Film

Cited by 17 publications

References 22 publications

Surface enhanced Raman scattering of p-aminothiophenol self-assembled monolayers in sandwich structure fabricated on glass

Surface enhanced Raman scattering of p-aminothiophenol self-assembled monolayers in sandwich structure fabricated on glass

Ultraviolet—Visible and Surface-Enhanced Raman Scattering Spectroscopy Studies on Self-Assembled Metalloporphyrin Films on Organic Monolayer-Modified Ultra-Thin Silver Substrates

Raman spectroscopic discrimination of estrogens

Contact Info

Product

Resources

About