Surface-enhanced Raman scattering in nanoliter droplets: towards high-sensitivity detection of mercury (II) ions

Wang, Guoqing; Lim, Chaesung; Chen, Lingxin; Chon, Hyangah; Choo, Jaebum; Hong, Jongin; deMello, Andrew J.

doi:10.1007/s00216-009-2832-7

Cited by 195 publications

(149 citation statements)

References 43 publications

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“…Since the discovery of the SERS effect in the 1970s [16][17][18], SERS has been applied to a wide variety of biomedical and environmental analytical applications at the level of molecules, pathogens, cells, and even whole living animals [19][20][21][22]. The enhancement associated with SERSup to 10 14 times [23]-is widely attributed to two primary mechanisms: the short-range chemical effect and the longrange classical electromagnetic effect.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

et al. 2011

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A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N=3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices.

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Section: Introductionmentioning

confidence: 99%

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

et al. 2011

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“…The LOD is as low as 1.0×10 −14 M. In comparison with the above mentioned SERS sensor performed on solid substrate, the SERS sensor performed in aqueous solution is more suitable for quantitative detection of Hg 2+ , due to the easy preparation and stability of liquid substrate. When the solution-phase metal NPs aggregate, intense electric fields known as "hot spots" can oc- [112] developed a SERS detection of Hg 2+ in aqueous environment within a droplet-based microfluidic system based on RB-adsorbed Au NPs. The addition of RB to the Au NPs solution led to the aggregation of Au NPs.…”

Section: Reviewsmentioning

confidence: 99%

Recent developments on nanomaterials-based optical sensors for Hg2+ detection

Duan

Zhan

2015

Sci. China Mater.

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Mercuric ion (Hg 2+ ), released from both natural and industrial sources, has severe adverse effects on human health and the environment even at very low concentrations. It is very important to develop a rapid and economical method for the detection of Hg 2+ with high sensitivity and selectivity. Nanomaterials with unique size and shape-dependent optical properties are attractive sensing materials. The application of nanomaterials to design optical sensors for Hg 2+ provides a powerful method for the trace detection of Hg 2+ in the environment, because these optical sensors are simple, rapidly responsive, cost-effective and highly sensitive. This review summarizes the recent advances on the development of optical assays for Hg 2+ in aqueous solution by using functionalized nanomaterials (including noble metal nanoparticles, fluorescent metal nanoclusters, semiconductor quantum dots and carbon nanodots). Detection strategies based on the Hg 2+ -induced changes in spectral absorbance, fluorescence intensity and surface-enhanced Raman scattering signals were described. And the design principles for each optical assay were presented. In addition, the future challenge and the prospect of the development of nanomaterial optical sensors for Hg 2+ detection were also discussed.

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“…The droplet-based microfluidic systems have been developed for the trace mercury (II) ions analysis in water. 48 As illustrated in Fig. 2(a) and (b), aqueous droplets containing mercury (II) ions and Rhodamine B-adsorbed gold nanoparticles (AuNPs) act as individual reaction vessels, and the aqueous droplets are encapsulated within nanoliter-sized droplets and are completely isolated by a continuous oil phase.…”

Section: Micromixermentioning

confidence: 99%

“…The use of SERS detection for the highly sensitive trace analysis of mercury (II) ions in water within a droplet-based microfluidic system has been demonstrated recently. 48 The novel combination of droplet-based microfluidics with SERS detection provides both fast and sensitive detection of mercury (II) ions in water. Choi et al 156 have presented a CD-based microfluidic device for high throughput SERS detections ( Fig.…”

Section: Environmentalmentioning

confidence: 99%

Surface-enhanced Raman scattering microfluidic sensor

Wang

2013

RSC Adv.

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Surface-enhanced Raman scattering (SERS) is a highly sensitive detection technique used to provide information about chemical and biological trace analytes. The confocal Raman microscope makes it possible to monitor small samples in a narrow microfluidic channel, despite the fact that the scattering intensity of the Raman signal is very weak. Recently, microfluidic chip devices coupled with on-chip SERS detection method and their applications to sensitive chemical and biological analyses have attracted significant attention. In this mini-review, highlights of advances in SERS techniques, microfluidic devices and their applications on the biological/environmental analysis of minute analytes within the recent years are provided to illustrate the impact of this rapidly growing area of research.

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Surface-enhanced Raman scattering in nanoliter droplets: towards high-sensitivity detection of mercury (II) ions

Cited by 195 publications

References 43 publications

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

Recent developments on nanomaterials-based optical sensors for Hg2+ detection

Surface-enhanced Raman scattering microfluidic sensor

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