Surface-Enhanced Raman Scattering Detection of DNA Derived from the West Nile Virus Genome Using Magnetic Capture of Raman-Active Gold Nanoparticles

Zhang, Hao; Harpster, Mark H.; Park, Hee Joon; Johnson, Patrick A.; Wilson, William C.

doi:10.1021/ac1023843

Cited by 121 publications

(58 citation statements)

References 46 publications

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“…157 A model paramagnetic NP assay was also demonstrated for SERS detection of DNA oligonucleotides derived from the West Nile virus (WNV) genome. 158 The detection was based on the capture of WNV target sequences by hybridization with complementary oligonucleotide probes covalently linked to the magnetic NPs and SERS tags. The resultant SERS tag−target sequence-magnetic NP complexes were removed from solution by an externally applied magnetic source.…”

Section: 149mentioning

confidence: 99%

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

2012

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Section: 149mentioning

confidence: 99%

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

2012

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“…Due to the advantages of the microfluidic system in SERS, immunoassays for protein detection have been developed based on microfluidics by SERS [76,77]. By using a magnetic pull-down system, proteins and DNA from viruses were detected effectively and such a system was very beneficial for SM or single-particle SERS study [78,79]. Most recently, with the development of optical tools and electron microscopy, super optical resolution imaging and STEM imaging have also contributed to SM-SERS development.…”

Section: Devices/systems For Single-molecule Surfaceenhanced Raman Spmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Wang

Irudayaraj

2013

Phil. Trans. R. Soc. B

104

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Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.

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“…The upgrade of such sorbents for simultaneous use in water purification and contaminant detection is a challenging task but of great practical interest for sensing applications, thus following current interest in developing multifunctional nanomaterials. In this context, the development of SERS-active magnetic nanomaterials has attracted much attention, because it provides innovative platforms that combine magnetic responsiveness and the ability for Raman monitoring within a single material [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Penicillin G (PG) belongs to the β-lactam antibiotics family whose structure is composed of a five-membered sulfur-containing thiazolidine ring fused to a beta-lactam ring and a phenyl ring attached to the side chain ( Figure S1, Supporting Information).…”

Section: Introductionmentioning

confidence: 99%

SERS Detection of Penicillin G Using Magnetite Decorated with Gold Nanoparticles

2017

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Sensitive and reliable procedures for detecting vestigial antibiotics are of great relevance for water quality monitoring due to the occurrence of such emergent pollutants in the aquatic environment. As such, we describe here research concerning the use of multifunctional nanomaterials combining magnetic and plasmonic components. These nanomaterials have been prepared by decorating magnetite nanoparticles (MNP) with colloidal gold nanoparticles (Au NPs) of distinct particle size distributions. Several analytical conditions were investigated in order to optimize the surface enhanced Raman scattering (SERS) detection of penicillin G (PG) dissolved in water. In particular, the dependence of the SERS signal by using distinct sized Au NPs adsorbed at the MNP was investigated. Additionally, microscopic methods, including Raman confocal microscopy, were employed to characterize the SERS substrates and then to qualitatively detect penicillin G using such substrates. For example, magnetic-plasmonic nanocomposites can be employed for magnetically concentrate analyte molecules and their removal from solution. As a proof of concept, we applied magneto-plasmonic nanosorbents in the removal of aqueous penicillin G and demonstrate the possibility of SERS sensing this antibiotic.

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Surface-Enhanced Raman Scattering Detection of DNA Derived from the West Nile Virus Genome Using Magnetic Capture of Raman-Active Gold Nanoparticles

Cited by 121 publications

References 46 publications

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

SERS Detection of Penicillin G Using Magnetite Decorated with Gold Nanoparticles

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