Surface-Enhanced Oxidation and Determination of Isothipendyl Hydrochloride at an Electrochemical Sensing Film Constructed by Multiwalled Carbon Nanotubes

Abstract

The electrochemical behavior of isothipendyl hydrochloride (IPH) was investigated at bare and multiwalled-carbon-nanotube modified glassy carbon electrode (MWCNT-GCE). IPH (55 μM) showed two oxidation peaks in Britton-Robinson (BR) buffer of pH 7.0. The oxidation process of IPH was observed to be irreversible over the pH range of 2.5-9.0. The influence of pH, scan rate, and concentration of the drug on anodic peak was studied. A differential pulse voltammetric method with good precision and accuracy was developed for the determination of IPH in pure and biological fluids. The peak current was found to be linearly dependent on the concentration of IPH in the range of 1.25-55 μM. The values of limit of detection and limit of quantification were noticed to be 0.284 and 0.949 μM, respectively.

Electrochemical Investigations of Biomolecules Using Carbon Nanotube and Graphene Based Modified Electrodes

“…The huge electroactive surface area and inherent excellent electron transfer properties of CNTs are being explored extensively in the field of electroanalytical chemistry as CNTs modified electrode offers low detection limit, high sensitivity, reduction of overpotential and resistance to surface fouling [9]. Seetharamappa, et al, have exploited MWCNTs modified glassy carbon electrodes (GCE) for detailed electrochemical investigations and development of analytical methods for several biologically important molecules or drugs [9,10]. Specifically, functionalized-MWCNTs (MWCNTs-COOH) prepared through refluxing with HNO3 and H2SO4, was used to modify the GCE surface (Figure 2a & b).…”