Surface engineering of stainless steel materials by covalent collagen immobilization to improve implant biocompatibility

Müller, Rainer; Abke, Jochen; Schnell, Edith; Macionczyk, F.; Gbureck, Uwe; Mehrl, Robert; Ruszczak, Zbigniev; Kujat, Richard; Englert, Carsten; Nerlich, Michael; Angele, Peter

doi:10.1016/j.biomaterials.2005.05.013

Cited by 121 publications

(89 citation statements)

References 40 publications

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“…Functional silanes, such as γ-APS, have often been used for modification of stainless steel [33] and Ti [30,34] to provide surface functionality for post chemical anchorage of biomolecules (e.g. collagen, heparin and fibronectin), with a view to improving the biocompatibility of these metallic implants.…”

Section: Corrosion Resistance Properties Of the Modified Az31 Mg Alloysmentioning

confidence: 99%

Biofunctionalized anti-corrosive silane coatings for magnesium alloys

et al. 2013

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Biodegradable magnesium alloys are advantageous in various implant applications, as they reduce the risks associated with permanent metallic implants. However, a rapid corrosion rate is usually a hindrance in biomedical applications. Here we report a facile two step procedure to introduce multifunctional, anticorrosive coatings on Mg alloys, such as AZ31. The first step involves treating the NaOH-activated Mg with bistriethoxysilylethane to immobilize a layer of densely crosslinked silane coating with good corrosion resistance; the second step is to impart amine functionality to the surface by treating the modified Mg with 3-amino-propyltrimethoxysilane. We characterized the two-layer anticorrosive coating of Mg alloy AZ31 by Fourier transform infrared spectroscopy, static contact angle measurement and optical profilometry, potentiodynamic polarization and AC impedance measurements. Furthermore, heparin was covalently conjugated onto the silane-treated AZ31 to render the coating haemocompatible, as demonstrated by reduced platelet adhesion on the heparinized surface. The method reported here is also applicable to the preparation of other types of biofunctional, anti-corrosive coatings and thus of significant interest in biodegradable implant applications.Keywords coatings, magnesium, alloys, corrosive, biofunctionalized, silane, anti Disciplines Engineering | Physical Sciences and Mathematics Publication DetailsLiu, X., Yue, Z., Romeo, T., Weber, J., Scheuermann, T., Moulton, S. & Wallace, G. (2013). Biofunctionalized anti-corrosive silane coatings for magnesium alloys. Acta Biomaterialia, 9 (10), 8671-8677. AuthorsXiao Liu, Zhilian Yue, Tony Romeo, Jan Weber, Torsten Scheuermann, Simon E. Moulton, and Gordon G. Wallace AbstractBiodegradable magnesium (Mg) alloys are advantageous in various implant applications, as they reduce the risks associated with permanent metallic implants. However, the fast corrosion rate is usually a hindrance in biomedical applications. Here we report a facile twostep procedure to introduce multifunctional, anticorrosive coatings on Mg alloys, such as AZ31. The first step involves treating the NaOH-activated Mg with bistriethoxysilylethane (BTSE) to immobilise a layer of densely crosslinked silane coating with good corrosion resistance; the second step is to impart amine functionality to the surface by treating the modified Mg with 3-amino-propyltrimethoxysilane (γ-APS). We characterised the two-layer anticorrosive coating of AZ31 Mg alloy by Fourier transform infrared spectroscopy, static contact angle measurement and optical profilometry, potentiodynamic polarization and AC impedance measurements. Furthermore, heparin was covalently conjugated onto the silane treated AZ31 to render the coating haemocompatible, as demonstrated by reduced platelet adhesion on the heparinised surface. The method reported here is also applicable to the preparation of other types of biofunctional, anticorrosive coatings, and thus of significant interest in biodegradable implant applications.

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Section: Corrosion Resistance Properties Of the Modified Az31 Mg Alloysmentioning

confidence: 99%

Biofunctionalized anti-corrosive silane coatings for magnesium alloys

et al. 2013

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“…The biocompatibility test of amine silane-treated bio-glass fibres showed no negative effect on the biological response [22]. Significant increases in cell adhesion and proliferation were detected on stainless steel surfaces coated with collagen and immobilised with an amino silane [23]. As a bioactive and biocompatible binder, glycidoxypropyltrimethoxysilane was used as a precursor for synthesis of a porous gelatine-siloxane hybrids for bone tissues [24,25].…”

Section: Introductionmentioning

confidence: 99%

Hexagonal Boron Nitride Impregnated Silane Composite Coating for Corrosion Resistance of Magnesium Alloys for Temporary Bioimplant Applications

Al-Saadi

Banerjee

Anisur

et al. 2017

Metals

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Magnesium and its alloys are attractive potential materials for construction of biodegradable temporary implant devices. However, their rapid degradation in human body fluid before the desired service life is reached necessitate the application of suitable coatings. To this end, WZ21 magnesium alloy surface was modified by hexagonal boron nitride (hBN)-impregnated silane coating. The coating was chemically characterised by Raman spectroscopy. Potentiodynamic polarisation and electrochemical impedance spectroscopy (EIS) of the coated alloy in Hanks' solution showed a five-fold improvement in the corrosion resistance of the alloy due to the composite coating. Post-corrosion analyses corroborated the electrochemical data and provided a mechanistic insight of the improvement provided by the composite coating.

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“…The first one was developed by the group of Dupont-Gillain et al and implies an adsorptive way of generating a collagen coating. [36] The second strategy includes the covalent attachment of collagen to an amine-functionalised Ti surface, developed by Mü ller et al [37] All applied coatings were studied by XPS to discriminate possible differences in chemical composition.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Collagen and Gelatin Coatings on Titanium Surfaces

Vanderleyden

Hoorebeke

Schacht

et al. 2011

Macromolecular Symposia

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To date, critical bone defects are mainly treated by implantation of a bio-inert metal such as titanium (Ti) or nickel-titanium alloys. The surface of such biomaterials is in direct contact with the host tissue and thus plays a critical role in determining the biocompatibility. There are several reports indicating that osteointegration of these implants is not optimal. In order to improve the integration of implants, it is desirable to control interfacial reactions such that tissue-healing phenomena can be controlled.1 Our goal is to apply natural polymers as stable bio-active coatings for porous Ti scaffolds. To achieve such a stable polymeric coating, we have applied a four-step-procedure: (1) cleaning, (2) oxidation and (3) silanisation of the titanium surface followed by (4) polymer immobilisation (figure 1).In the present work we compared the immobilisation of collagen type I with the immobilisation of its hydrolysed derivative, gelatin. Collagen is one of the most usefull biomaterials due to its excellent biocompatibility, biodegradability and weak antigenicity. Still, a more economical choice would be gelatin. Collagen was immobilised onto the Ti surface in an adsorptive and in a covalent manner. 2,3 Only the latter proved to lead to a stable coating. This method comprised of a silanisation with 3-aminopropyltriethoxysilane (APTES) to introduce amines to the Ti surface. In a next step, these amines can react with the carboxylic acid groups of collagen by using a coupling reagent. Without any doubt, there will also be intra-and intermolecular crosslinking between the collagen chains. In case of gelatin, we followed a different approach. Gelatin was modified with metacrylamide groups (Gel-mod) and the Ti surface was modified with methacrylate groups through silanisation using 3-(trimethoxysilyl)propyl methacrylate (TMSPMA). Crosslinking between both was achieved by e-beam treatment.

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Surface engineering of stainless steel materials by covalent collagen immobilization to improve implant biocompatibility

Cited by 121 publications

References 40 publications

Biofunctionalized anti-corrosive silane coatings for magnesium alloys

Biofunctionalized anti-corrosive silane coatings for magnesium alloys

Hexagonal Boron Nitride Impregnated Silane Composite Coating for Corrosion Resistance of Magnesium Alloys for Temporary Bioimplant Applications

Comparative Study of Collagen and Gelatin Coatings on Titanium Surfaces

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