Surface engineering of biomaterials with plasma techniques

Poncin-Epaillard, Fabienne; Legeay, G.

doi:10.1163/156856203769231538

Cited by 136 publications

(60 citation statements)

References 68 publications

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“…These changes ultimately increased the surface free energy (γ s ) of PU from 37.76±0.80 mJ/m 2 to 46.69±1.01 mJ/m 2 in the fabricated dressing, and it is comparable with the optimum range reported in the literature. 52 This outcome depicts higher concentration of polar molecules in PU-HN-PA mesh and also validates the results of the FTIR and contact angle assay. The specific protein adsorption is influenced by various physicochemical properties, and the surface energy is one of the important factors.…”

Section: Surface Energy Of Fabricated Nanofiberssupporting

confidence: 84%

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

Balaji

Jaganathan

Ismail

et al. 2016

IJN

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Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in burn victims. To assist burn wound management, a novel polyurethane (PU)-based bio-nanofibrous dressing loaded with honey (HN) and Carica papaya (PA) fruit extract was fabricated using a one-step electrospinning technique. The developed dressing material had a mean fiber diameter of 190±19.93 nm with pore sizes of 4–50 µm to support effective infiltration of nutrients and gas exchange. The successful blending of HN- and PA-based active biomolecules in PU was inferred through changes in surface chemistry. The blend subsequently increased the wettability (14%) and surface energy (24%) of the novel dressing. Ultimately, the presence of hydrophilic biomolecules and high porosity enhanced the water absorption ability of the PU-HN-PA nanofiber samples to 761.67% from 285.13% in PU. Furthermore, the ability of the bio-nanofibrous dressing to support specific protein adsorption (45%), delay thrombus formation, and reduce hemolysis demonstrated its nontoxic and compatible nature with the host tissues. In summary, the excellent physicochemical and hemocompatible properties of the developed PU-HN-PA dressing exhibit its potential in reducing the clinical complications associated with the treatment of burn injuries.

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Section: Surface Energy Of Fabricated Nanofiberssupporting

confidence: 84%

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

Balaji

Jaganathan

Ismail

et al. 2016

IJN

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“…By appropriate choice of bioassay, the material presenting the optimised performance can be readily selected. The absence of adequate polymeric materials for biomedical application and, thus, the motivation for materials discovery, is well illustrated by the prevalence of surface modification of polymers in an attempt to achieve the required surface properties [35][36][37][38][39][40][41][42][43][44][45][46][47]. The creation of a diverse range of polymeric materials is an important requirement for producing biomaterials ideally suited to the unique and specific requirements of every medical application [20].…”

Section: Introductionmentioning

confidence: 99%

High throughput methods applied in biomaterial development and discovery

et al. 2010

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The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the literature in this area and conclude that for polymers, this process is best achieved in a microarray format, which enable thousands of cell-material interactions to be monitored on a single chip. Polymer microarrays can be formed by printing pre-synthesised polymers or by printing monomers onto the chip where on-slide polymerisation is initiated.The surface properties of the material can be analysed and correlated to the biological performance using high throughput surface analysis, including time-of-flight secondary ion mass spectrometry (ToF-SIMS), Xray photoelectron spectroscopy (XPS) and water contact angle (WCA) measurements. This approach enables the surface properties responsible for the success of a material to be understood, which in turn provides the foundations of future material design. The high throughput discovery of materials using polymer microarrays has been explored for many cell-based applications including the isolation of specific 2 cells from heterogeneous populations, the attachment and differentiation of stem cells and the controlled transfection of cells.Further development of polymerisation techniques and high throughput biological assays amenable to the polymer microarray format will broaden the combinatorial space and biological phenomenon that polymer microarrays can explore, and increase their efficacy. This will, in turn, result in the discovery of optimised polymeric materials for many biomaterial applications.

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“…In general, surfaces with high energy allow uniform biofilm formation, which in turn produces better spreading of water droplets. 39 Accordingly, coated samples were observed to facilitate spreading of water droplets, which supports the fact of increased surface energy. The spreading of water droplets on control and Aloe vera-coated samples is illustrated in Figure 4.…”

Section: Contact Angle Measurementmentioning

confidence: 62%

Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

Balaji¹,

Jaganathan²,

Supriyanto³

et al. 2015

IJN

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Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera , a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera -induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera -glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants.

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Surface engineering of biomaterials with plasma techniques

Cited by 136 publications

References 68 publications

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and <em>Carica papaya</em> extract for the management of burn injuries

High throughput methods applied in biomaterial development and discovery

Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

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