Surface engineering of biomaterials in orthopedic and dental implants: Strategies to improve osteointegration, bacteriostatic and bactericidal activities

Liu, Ziqian; Liu, Xiaoling; Ramakrishna, Seeram

doi:10.1002/biot.202000116

Cited by 70 publications

(45 citation statements)

References 179 publications

(250 reference statements)

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“…[ 366 ]. Metallic/metal oxide nanoparticles, i.e., silver, gold, magnesium, titanium, zinc, aluminum, tantalum, and zirconium have been tested in orthopedics [ 367 , 368 , 369 , 370 ]. Nanoparticles embedded in implants and orthopedic scaffolds provide mechanical strength and antimicrobial protection.…”

Section: Synthesis Of Nanoparticles (Nps) By Natural Extractsmentioning

confidence: 99%

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

et al. 2021

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Natural extracts are the source of many antioxidant substances. They have proven useful not only as supplements preventing diseases caused by oxidative stress and food additives preventing oxidation but also as system components for the production of metallic nanoparticles by the so-called green synthesis. This is important given the drastically increased demand for nanomaterials in biomedical fields. The source of ecological technology for producing nanoparticles can be plants or microorganisms (yeast, algae, cyanobacteria, fungi, and bacteria). This review presents recently published research on the green synthesis of nanoparticles. The conditions of biosynthesis and possible mechanisms of nanoparticle formation with the participation of bacteria are presented. The potential of natural extracts for biogenic synthesis depends on the content of reducing substances. The assessment of the antioxidant activity of extracts as multicomponent mixtures is still a challenge for analytical chemistry. There is still no universal test for measuring total antioxidant capacity (TAC). There are many in vitro chemical tests that quantify the antioxidant scavenging activity of free radicals and their ability to chelate metals and that reduce free radical damage. This paper presents the classification of antioxidants and non-enzymatic methods of testing antioxidant capacity in vitro, with particular emphasis on methods based on nanoparticles. Examples of recent studies on the antioxidant activity of natural extracts obtained from different species such as plants, fungi, bacteria, algae, lichens, actinomycetes were collected, giving evaluation methods, reference antioxidants, and details on the preparation of extracts.

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Section: Synthesis Of Nanoparticles (Nps) By Natural Extractsmentioning

confidence: 99%

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

et al. 2021

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“…Passive coatings function by decreasing non-specific interactions and cell attachment to the biomaterial surface [237]. The incorporation of polymer brushes (passive coating) consisting of antimicrobial agents to the surface is one of the advanced methods for preventing microbial adhesion [21,238,239]. Figure 26 illustrates two methods for the functioning of passive coating consisting of antimicrobial agents.…”

Section: Future Scope Of Surface Engineered Biomaterialsmentioning

confidence: 99%

“…Enhancement of surface attributes of a material via coating or some other engineering technique is termed as surface engineering [20]. Surface modification has significant role in biomedical application in terms of enhancing osteointegration, preventing corrosion, and inhibiting bacterial infection [21]; to discard ineffectiveness of bactericides due to development of bacterial film [22]; and to create biomaterials with antibacterial and antiviral property [23]. Figure 4 displays the surface modification of biomaterials to prevent microbial contamination and corrosion.…”

Section: Introductionmentioning

confidence: 99%

Surface Engineering Strategies to Enhance the In Situ Performance of Medical Devices Including Atomic Scale Engineering

Sultana

Zare

Luo

et al. 2021

IJMS

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Decades of intense scientific research investigations clearly suggest that only a subset of a large number of metals, ceramics, polymers, composites, and nanomaterials are suitable as biomaterials for a growing number of biomedical devices and biomedical uses. However, biomaterials are prone to microbial infection due to Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), hepatitis, tuberculosis, human immunodeficiency virus (HIV), and many more. Hence, a range of surface engineering strategies are devised in order to achieve desired biocompatibility and antimicrobial performance in situ. Surface engineering strategies are a group of techniques that alter or modify the surface properties of the material in order to obtain a product with desired functionalities. There are two categories of surface engineering methods: conventional surface engineering methods (such as coating, bioactive coating, plasma spray coating, hydrothermal, lithography, shot peening, and electrophoretic deposition) and emerging surface engineering methods (laser treatment, robot laser treatment, electrospinning, electrospray, additive manufacturing, and radio frequency magnetron sputtering technique). Atomic-scale engineering, such as chemical vapor deposition, atomic layer etching, plasma immersion ion deposition, and atomic layer deposition, is a subsection of emerging technology that has demonstrated improved control and flexibility at finer length scales than compared to the conventional methods. With the advancements in technologies and the demand for even better control of biomaterial surfaces, research efforts in recent years are aimed at the atomic scale and molecular scale while incorporating functional agents in order to elicit optimal in situ performance. The functional agents include synthetic materials (monolithic ZnO, quaternary ammonium salts, silver nano-clusters, titanium dioxide, and graphene) and natural materials (chitosan, totarol, botanical extracts, and nisin). This review highlights the various strategies of surface engineering of biomaterial including their functional mechanism, applications, and shortcomings. Additionally, this review article emphasizes atomic scale engineering of biomaterials for fabricating antimicrobial biomaterials and explores their challenges.

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“…[ 2 ] To slow down the corrosion process and improve the biological tissue reaction of Mg‐based implants, alloying, and various surface treatments, such as electrophoresis deposition and micro‐arc oxidation (MAO), have been applied to bone implant interfaces. [ 3–6 ]…”

Section: Introductionmentioning

confidence: 99%

A biodegradable, mechanically tunable micro‐arc oxidation AZ91D‐based composite implant with calcium phosphate/chitosan coating promotes long‐term bone tissue regeneration

Liu

Yang

Zhang

et al. 2021

Biotechnology Journal

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Background To reduce the biodegradable rate and develop the long‐term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D‐based composite implant with calcium phosphate/chitosan coating (CaP‐CS/MAO/AZ91D) and investigated its mechanical property and long‐term bone tissue regeneration ability. Main Methods and Major Results The results showed that the binding force and bioactivity of CaP‐CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm−2. Compressive strengths of 4:6 sample were more than 1300 N when the soaking time was increased to 21 days. CaP‐CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers. Conclusions and Implications CaP‐CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β‐catenin pathway activation, which would allow sufficient time for bone healing. Collectively, our findings suggest that the CaP‐CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long‐term biocompatibility but also promote osteogenic mineralization.

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Surface engineering of biomaterials in orthopedic and dental implants: Strategies to improve osteointegration, bacteriostatic and bactericidal activities

Cited by 70 publications

References 179 publications

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

Surface Engineering Strategies to Enhance the In Situ Performance of Medical Devices Including Atomic Scale Engineering

A biodegradable, mechanically tunable micro‐arc oxidation AZ91D‐based composite implant with calcium phosphate/chitosan coating promotes long‐term bone tissue regeneration

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