Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme

Sahoo, Rakesh Kumar; Gupta, Tanisha; Batheja, Sanya; Goyal, Amit K.; Gupta, Umesh

doi:10.2174/1389200223666220616125524

Cited by 4 publications

(4 citation statements)

References 144 publications

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“…Amphiphilic peptide dendrimers [ 212 ], poly(propyleneimine) [ 213 ] and Poly(L-lysine) [ 214 ] were used for the same purpose as well. Surface modifications of dendrimers were studied for effectiveness in targeting GBM [ 215 ].…”

Section: Nanocarrier Treatment Optionsmentioning

confidence: 99%

Mechanisms of Resistance and Current Treatment Options for Glioblastoma Multiforme (GBM)

Yalamarty

Filipczak

et al. 2023

Cancers

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Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to both radiation and chemotherapy. This resistance is largely due to the unique biology of GBM cells, which can evade the effects of conventional treatments through mechanisms such as increased resistance to cell death and rapid regeneration of cancerous cells. Additionally, the blood–brain barrier makes it difficult for chemotherapy drugs to reach GBM cells, leading to reduced effectiveness. Despite these challenges, there are several treatment options available for GBM. The standard of care for newly diagnosed GBM patients involves surgical resection followed by concurrent chemoradiotherapy and adjuvant chemotherapy. Emerging treatments include immunotherapy, such as checkpoint inhibitors, and targeted therapies, such as bevacizumab, that attempt to attack specific vulnerabilities in GBM cells. Another promising approach is the use of tumor-treating fields, a type of electric field therapy that has been shown to slow the growth of GBM cells. Clinical trials are ongoing to evaluate the safety and efficacy of these and other innovative treatments for GBM, intending to improve with outcomes for patients.

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Section: Nanocarrier Treatment Optionsmentioning

confidence: 99%

Mechanisms of Resistance and Current Treatment Options for Glioblastoma Multiforme (GBM)

Yalamarty

Filipczak

et al. 2023

Cancers

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Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

“…The most prevalent primary brain tumors (intra-axial) in adults with significant heterogeneity are gliomas [ 93 ]. They primarily have neuroepithelial origins and have various mutational profiles in different patients [ 93 ]. According to the type of glial cells implicated in the tumor, these are made up of astrocytomas, oligodendrogliomas, and ependymomas and share characteristics with the glial cells of the brain [ 93 ].…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

“…They primarily have neuroepithelial origins and have various mutational profiles in different patients [ 93 ]. According to the type of glial cells implicated in the tumor, these are made up of astrocytomas, oligodendrogliomas, and ependymomas and share characteristics with the glial cells of the brain [ 93 ]. Glioblastoma stem cells, which are extremely invasive, aggressive, and therapy-resistant, make up the glioma cells.…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

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Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Trends in research on nanomedicine in urologic cancer: a bibliometric and visualized analysis

Lan,

Feng,

Chen

et al. 2024

Discov Onc

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Increasing research efforts are focused on studying the synthesis and mechanisms of nanomedicine in urologic cancer. We performed a bibliometric study of the literature on nanomedicine in urologic cancer over the last 23 years, focusing on aspects such as researchers, institutions, nations, and keywords. We searched for papers in the Web of Science Core Collection from January 1, 2001, to December 29, 2023. Only reviews and original articles written in English were considered. A total of 2386 papers satisfied the given criteria for inclusion. The publications included in the study originated from 90 nations. The United States had the largest number of published papers, accounting for more than 31.01% of the total. The leading institution in this field is the Chinese Academy of Sciences, with a publishing output of 2.35%. Farokhzad, Omid C., is the most prolific author, with 21 articles, and has garnered the most citations, totaling 6271. The latest phrase to enter the top ten most common lists was "gold nanoparticles." We searched for papers in the Web of Science Core Collection from January 1, 2000, to November 28, 2023. Only reviews and original articles written in English were considered. This is the first bibliometric study of nanomedicine in urologic cancer. This article provides a comprehensive analysis of the current state of research on nanomedicine in urologic cancer over the last 23 years. On the basis of this study, future researchers can identify noteworthy publications, journals, and potential collaborators and explore cutting-edge research directions.

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Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme

Cited by 4 publications

References 144 publications

Mechanisms of Resistance and Current Treatment Options for Glioblastoma Multiforme (GBM)

Mechanisms of Resistance and Current Treatment Options for Glioblastoma Multiforme (GBM)

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Trends in research on nanomedicine in urologic cancer: a bibliometric and visualized analysis

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