Surface engineered biomaterials and ureteral stents inhibiting biofilm formation and encrustation

Vladkova, T.; Staneva, A.; Gospodinova, D. N.

doi:10.1016/j.surfcoat.2020.126424

Cited by 29 publications

(35 citation statements)

References 138 publications

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“…The combat with the biofilms is complicated by several phenomena: the secretion of different EPSs by different microbial species, as well as by one and the same microbial cells on different surfaces; the versatile nature of adhesive proteins using different adsorption mechanisms in front of complementary surfaces; the concurrent adsorption of EPSs constituents, similar to the Vroman effect in the adsorption of mixed proteins [19], etc. The adhesion of microbial cells to the material surface is always the event, initiating each step in the development of biofilm, and therefore, if one is able to stop this process, the development of biofilm will be prevented [11,16,18].…”

Section: Microbial Biofilmsmentioning

confidence: 99%

“…A large variety of approaches and a number of materials are in use for development of antimicrobial surfaces and coatings: strong hydrophilic and strong hydrophobic polymers and polymer gels, antimicrobial peptides, specific drugs and biodegradables, new antibiotics, nanostructured composite coatings, metal and metal oxide nanoparticles, enzymes, quorum sensing (QS) inhibitors, antiadhesion agents, bacteriophages, etc., all of which are considered as experimental [ 10 , 11 , 20 , 21 , 22 , 23 ].…”

Section: Microbial Biofilmsmentioning

confidence: 99%

“…One general approach to mitigate the problem is surface modification or antimicrobial coating deposition to create heparinized, drug-delivering, cationic polymer or antimicrobial peptide immobilized antimicrobial surfaces and others, each one with its own advantages and shortcomings [ 10 ]. Due to increasing microbial resistance to conventional antibiotics, interest in material surface engineering by novel antimicrobial agents, and especially of carbon materials, has increased [ 11 ]. Graphene (Gr), which was discovered in 2004, is one of them.…”

Section: Introductionmentioning

confidence: 99%

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Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

et al. 2021

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Microbial adhesion and biofilm formation is a common, nondesirable phenomenon at any living or nonliving material surface in contact with microbial species. Despite the enormous efforts made so far, the protection of material surfaces against microbial adhesion and biofilm formation remains a significant challenge. Deposition of antimicrobial coatings is one approach to mitigate the problem. Examples of such are those based on heparin, cationic polymers, antimicrobial peptides, drug-delivering systems, and other coatings, each one with its advantages and shortcomings. The increasing microbial resistance to the conventional antimicrobial treatments leads to an increasing necessity for new antimicrobial agents, among which is a variety of carbon nanomaterials. The current review paper presents the last 5 years’ progress in the development of graphene antimicrobial materials and graphene-based antimicrobial coatings that are among the most studied. Brief information about the significance of the biofouling, as well as the general mode of development and composition of microbial biofilms, are included. Preparation, antibacterial activity, and bactericidal mechanisms of new graphene materials, deposition techniques, characterization, and parameters influencing the biological activity of graphene-based coatings are focused upon. It is expected that this review will raise some ideas for perfecting the composition, structure, antimicrobial activity, and deposition techniques of graphene materials and coatings in order to provide better antimicrobial protection of medical devices.

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Section: Microbial Biofilmsmentioning

confidence: 99%

Section: Microbial Biofilmsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

et al. 2021

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“…[38,39] On the other hand, hydrophobic coatings, as polytetrafluoroethylene (PTFE) and corethane, have also been studied for ureteral stent coating application, and their effectiveness in preventing the luminal occlusion caused by urothelial hyperplasia has already been proven. [40,41] Concerning organic approaches, the future research must involve more detailed studies regarding biomolecule-based coatings, which attempt to impart biomimetic and biocompatible properties to the stent surface. These strategies follow a similar rationale as the one made for the already approved heparin-based coating, however, apart from polysaccharides (heparin), other biomolecules can be applied.…”

Section: Coatingsmentioning

confidence: 99%

Future Directions for Ureteral Stent Technology: From Bench to the Market

Domingues

Pacheco

Cruz

et al. 2021

Advanced Therapeutics

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Ureteral stents are broadly used for the treatment of a wide range of pathologies, with different complexities and characteristics. Despite being efficient, the morbidity associated with stents, such as bacterial infection and pain, limits their therapeutic action and often represents an increase in healthcare costs. As no single solution fits all problems, there is still a need to improve these medical devices. Throughout this review, the most recent innovations are outlined and suggestions regarding future directions for ureteral stent technology are formulated with respect to materials, coatings, and designs of these devices. As highlighted here, during the process of passing these innovations to the growing market of ureteral stents, one of the biggest challenges is to increase the predictive value of the in vitro assays and, consequently, reduce the number of in vivo tests needed. Thus, recommendations concerning in vitro standard testing of these devices are provided, with focus on medium, flow conditions, and microbiological parameters. Additionally, the reader is also presented with insights about a crucial but rarely discussed topic, the bureaucratic part of the bench to market process, particularly the product certification legislation in Europe.

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“…[22] Stent re-closures often occur due to the encrustation of stone formation on the surface and lumen of an indwelling stent, leading to the condition known as hydronephrosis, or swelling of the kidney. [18,23] In certain cases, hydronephrosis deteriorates to result in the build-up of crystals inside and outside the stent, which, in turn, can lead to blocking of the ureter [21] and further to damaging of the kidney due to its increased pressure. [24] Although the studies of drugeluting and surface-modified stents have shown promise in preventing hydronephrosis, [23,25,26] their usage has been limited due to challenges in infectious urinary settings as well as coating reliability.…”

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confidence: 99%

Intelligent Ureteral Stent for Early Detection of Hydronephrosis

Darestani

Shalabi

Lange

et al. 2021

Adv Materials Technologies

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Millions of people around the world currently suffer from kidney stone diseases. While ureteral stenting is an unmistakably effective treatment of these patients, their long‐term adverse effects can result in the build‐up of crystals around the stent. This, in turn, can lead to new ureter blockages that can dangerously increase kidney pressure, a condition known as hydronephrosis, which, if severe and prolonged, can cause irreversible kidney damage. Toward enabling early detection of hydronephrosis, this paper investigates the first intelligent ureteral stent with an integrated radiofrequency antenna and micro pressure sensor for resonance‐based wireless tracking of kidney pressure. Prototyping is conducted using a commercial ureteral stent as the substrate for microfabrication of the device. The packaged device is experimentally assessed for electrical characterizations and wireless pressure sensing using an in vitro test model. Preliminary telemetry testing demonstrates the fundamental ability of the device with its approximately linear responses of up to 1.7 kHz mmHg−1 over a pressure range of up to 120 mmHg in air, water, and artificial urine. These findings verify the efficacy of the device design and the approach to kidney pressure monitoring through indwelling stents, paving the way for the transfer of this technology to today's ureteral stent products.

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Surface engineered biomaterials and ureteral stents inhibiting biofilm formation and encrustation

Cited by 29 publications

References 138 publications

Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

Antibiofouling Activity of Graphene Materials and Graphene-Based Antimicrobial Coatings

Future Directions for Ureteral Stent Technology: From Bench to the Market

Intelligent Ureteral Stent for Early Detection of Hydronephrosis

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