Surface energetics of bone mineral and synthetic hydroxyapatite using inverse gas chromatography

Hole, Bhushan B.; Keller, D. Steven; Burry, William M.; Schwarz, John H.

doi:10.1016/j.jchromb.2011.04.035

Cited by 13 publications

(10 citation statements)

References 16 publications

(17 reference statements)

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“…Figure 3(c) has illustrated the transition that CAP nanoparticles underwent during desiccation: aggregation into compact microsized blocks. The naturally rough surface of CAP particles exhibits topographic irregularities on the atomic scale,38, 39 which does not only favor protein adsorption,40 osteoblast differentiation,41 and expression of osteogenic markers42 but also causes high levels of adhesion upon contact, promoting facile formation and retention of stable aggregates even under relatively intensive agitations in the solution. This propensity of the particles to form aggregates subsequently stable in solution was used as the primary mechanism for loading the powders with small organic molecules.…”

Section: Resultsmentioning

confidence: 99%

Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis

Brunner

Bennett

Mina

et al. 2012

Arthritis & Rheumatism

142

111

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Objective To investigate the relationship of urinary biomarkers (UBM) and established measures of renal function (EMRF) to the histological findings with lupus nephritis (LN); and to test whether certain combinations of the above mentioned laboratory measures are diagnostic of specific histological features of LN. Methods Urine samples of 76 patients were collected within 2 months of a kidney biopsy and assayed for the UBM: lipocalin-like prostaglandin-D synthetase (LPGDS), α1-acid-glycoprotein (AAG), transferrin (TF), ceruloplasmin (CP), neutrophil-gelatinase associated lipocalin (NGAL), and monocyte chemotactic factor 1 (MCP1). Using non-parametric analyses, UBM and EMRF levels were compared to histological features seen with LN: mesangial expansion, capillary proliferation, crescent formation, necrosis, wire loops, fibrosis, tubular atrophy, and epimembranous deposits. The area under the receiver operating characteristic (AUC) curve was calculated to predict LN activity, chronicity or membranous LN. Results There was a differential increase of the UBM that formed a pattern reflective of specific histological features seen with active LN. The combination of MCP1, AAG, CP plus protein:creatinine ratio were excellent in predicting LN activity (AUC=0.85). NGAL together with creatinine clearance plus MCP1 was an excellent (AUC=0.83) and MCP1, AAG, creatinine clearance plus C4 (AUC=0.75) a good diagnostic test of LN chronicity and membranous LN, respectively. Conclusions Select UBM are associated with specific tissue changes observed with LN activity and chronicity. Especially in combination with select EMRF, UBM are well-suited to non-invasively quantify LN activity, LN chronicity, and the presence of membranous LN.

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Section: Resultsmentioning

confidence: 99%

Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis

Brunner

Bennett

Mina

et al. 2012

Arthritis & Rheumatism

142

111

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“…For instance, fillers with high amounts of active surface hydrogen ions, generate strong filler-filler networks that can lead to agglomeration problems during processing and limit the reinforcement efficiency of the filler in most non-polar elastomers. Although high energy sites are mainly associated with functional groups [18,40,65], the surface activity also depends on the accessibility of these sites, which is determined by the arrangement and orientation of surface chemical groups [66,67]. Furthermore, high energy sites also can arise at structural heterogeneities, such as boundaries between crystallites and amorphous regions [19,67,68].…”

Section: Surface Activitymentioning

confidence: 99%

Characterization of Agricultural and Food Processing Residues for Potential Rubber Filler Applications

Barrera

Cornish

2019

J. Compos. Sci.

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Large volumes of agricultural and food processing residues are generated daily around the world. Despite the various potential uses reported for this biomass, most are still treated as waste that requires disposal and negatively impacts the environmental footprint of the primary production process. Increasing attention has been paid toward the use of these residues as alternative fillers for rubber and other large-scale commodity polymers to reduce dependence on petroleum. Nevertheless, characterization of these alternative fillers is required to define compatibility with the specific polymer, identify filler limitations, understand the properties of the resulting composites, and modify the materials to enable the engineering of composites to exploit all the potential advantages of these residue-derived fillers.

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“…92,93 Together, these substitutions heavily influence the resulting chemistry of bone mineral in terms crystallinity, thermodynamic stability, morphology, solubility and biological properties. [94][95][96][97] Typically, HA exhibits two crystallographic forms; a hexagonal form that crystallises above 250 1C (P6 3 /m space group with unit cell parameters a = b = 9.432 Å, c = 6.881 Å) and a monoclinic form that crystallises below 250 1C (P2 1 /b space group with unit cell parameters a = 9.421 Å, b = 2 Å, c = 6.881 Å, b = 1201). 98,99 Whilst impurities can cause the Ca : P ratio of biological mineral to fall as low as 1.3, the combination of foreign ion inclusions, ionic vacancies and Ca 2+ deficiencies in fact contributes to stabilising biological HA in the hexagonal crystal form.…”

Section: àmentioning

confidence: 99%

Critical and diverse roles of phosphates in human bone formation

et al. 2019

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Surface energetics of bone mineral and synthetic hydroxyapatite using inverse gas chromatography

Cited by 13 publications

References 16 publications

Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis

Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis

Characterization of Agricultural and Food Processing Residues for Potential Rubber Filler Applications

Critical and diverse roles of phosphates in human bone formation

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