Surface Decorated Gold Nanoparticles by Linear and Cyclic Peptides as Molecular Transporters

Shirazi, Amir Nasrolahi; Tiwari, Rakesh; Oh, Donghoon; Sullivan, B. Patrick; McCaffrey, Kellen; Mandal, Dindyal; Parang, Keykavous

doi:10.1021/mp400199e

Cited by 31 publications

(35 citation statements)

References 41 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 5 TEM investigations showed that l(KW) 5 -AuNPs formed ball-shaped structures with the diameter size of 900–1000 nm (Figure 16). A large number of l(KW) 5 -AuNPs were found to be in spherical morphologies and in the size range of 4–35 nm.…”

Section: Peptide Nanostructuresmentioning

confidence: 99%

Self-assembly of peptides to nanostructures

2014

Self Cite

View full text Add to dashboard Cite

The formation of well-ordered nanostructures through self-assembly of diverse organic and inorganic building blocks has drawn much attention owing to their potential applications in biology and chemistry. Among all organic building blocks, peptides are one of the most promising platforms due to their biocompatibility, chemical diversity, and resemblance with proteins. Inspired from the protein assembly in biological systems, various self-assembled peptide structures have been constructed using several amino acids and sequences. This review focuses on this emerging area, the recent advances in peptide self-assembly, and formation of different nanostructures, such as tubular, fibers, vesicles, spherical, and rod coil structures. While different peptide nanostructures are discovered, potential applications will be explored in drug delivery, tissue engineering, wound healing, and surfactants.

show abstract

Section: Peptide Nanostructuresmentioning

confidence: 99%

Self-assembly of peptides to nanostructures

2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…CD studies were conducted according to our previously reported method. 40 All experiments on the samples including [W 5 R 4 C] (50 μM, H 2 O), [W 5 R 4 C]–SeNPs (50 μM, H 2 O), and camptothecin (CPT, 5 μM, DMSO) were performed by using a ratio of 10:1 between the carrier and the drug at room temperature. All measurements were performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

“…The cytotoxicity assay was performed by using SK-OV-3 (5000), HEK-293T (4000), and CCRF-CEM (40 000) cells based on our reported procedure. 40 The only modification was that the old medium was not replaced in the case of CCRF-CEM by treatments. The compounds were added to the old medium instead.…”

Section: Methodsmentioning

confidence: 99%

“…The procedures for washing the slides and staining the cell nuclei by 4,6-diamidino-2-phenylindole (DAPI) were previously reported by us. 40 All assays were conducted in triplicate assays.…”

Section: Methodsmentioning

confidence: 99%

“…The methods for HPLC and quantifying the Dox amount was previously reported by us. 40 All measurements were performed in triplicate.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Cyclic Peptide–Selenium Nanoparticles as Drug Transporters

Shirazi

Tiwari

et al. 2014

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

A cyclic peptide composed of five tryptophan, four arginine, and one cysteine [W5R4C] was synthesized. The peptide was evaluated for generating cyclic peptide-capped selenium nanoparticles (CP–SeNPs) in situ. A physical mixing of the cyclic peptide with SeO3–2 solution in water generated [W5R4C]–SeNPs via the combination of reducing and capping properties of amino acids in the peptide structure. Transmission electron microscopy (TEM) images showed that [W5R4C]–SeNPs were in the size range of 110–150 nm. Flow cytometry data revealed that a fluorescence-labeled phosphopeptide (F′-PEpYLGLD, where F′ = fluorescein) and an anticancer drug (F′-dasatinib) exhibited approximately 25- and 9-times higher cellular uptake in the presence of [W5R4C]–SeNPs than those of F′-PEpYLGLD and dasatinib alone in human leukemia (CCRF-CEM) cells after 2 h of incubation, respectively. Confocal microscopy also exhibited higher cellular delivery of F′-PEpYLGLD and F′-dasatinib in the presence of [W5R4C]–SeNPs compared to the parent fluorescence-labeled drug alone in human ovarian adenocarcinoma (SK-OV-3) cells after 2 h of incubation at 37 °C. The antiproliferative activities of several anticancer drugs doxorubicin, gemcitabine, clofarabine, etoposide, camptothecin, irinotecan, epirubicin, fludarabine, dasatinib, and paclitaxel were improved in the presence of [W5R4C]–SeNPs (50 μM) by 38%, 49%, 36%, 36%, 31%, 30%, 30%, 28%, 24%, and 17%, respectively, after 48 h incubation in SK-OV-3 cells. The results indicate that CP–SeNPs can be potentially used as nanosized delivery tools for negatively charged biomolecules and anticancer drugs.

show abstract

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

Friedl

Nele

Rosa

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote drug transport across membranes, to protect their payload from premature degradation, and to deliver drugs in a controlled and targeted manner. Their performance strongly depends on the surface chemistry, which governs their interaction with the biological environment. Bioinert and stealth surface features are advantageous to avoid unintended interactions with endogenous surfaces at off‐target sites and with the immune system, whereas at the target site these carriers should be highly interactive guaranteeing intracellular delivery of their payload. These key surface properties—bioinert and stealth versus interactive at the target site—are in contradiction to each other so that the best compromise between them has to be found. Alternatively, surface structures interacting preferentially with the membrane of target cells can be utilized. Stimuli‐responsive surfaces able to convert from bioinert and stealth to interactive at the target site have been recently introduced. A deepened understanding of how these different approaches influence the performance of NCs in the body is of particular importance in order to improve their efficacy. This review focuses on the surface chemistry of NCs providing the best compromise between bioinert and stealth versus interactive features.

show abstract

Surface Decorated Gold Nanoparticles by Linear and Cyclic Peptides as Molecular Transporters

Cited by 31 publications

References 41 publications

Self-assembly of peptides to nanostructures

Self-assembly of peptides to nanostructures

Cyclic Peptide–Selenium Nanoparticles as Drug Transporters

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

Contact Info

Product

Resources

About