Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease

Tabuchi, Ryo; Anraku, Makoto; Iohara, Daisuke; Ishiguro, Takako; Ifuku, Shinsuke; Nagae, Tomone; Uekama, Kaneto; Okazaki, Shoko; Takeshita, Keizo; Otagiri, Masaki; Hirayama, Fumitoshi

doi:10.1016/j.carbpol.2017.07.028

Cited by 18 publications

(9 citation statements)

References 36 publications

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“…35,37−44 Even, Basu et al have reported the masked bitter taste of prednisolone obtained by the inclusion complexation with βCD in the tablet that they developed as a mouth-dissolving formulation. 43 The electrospinning of prednisolone incorporated nanofibrous webs has been also studied for the purpose of a sustained 45 and fast release. 46 In one of these related studies, Tawfik et al have generated orally disintegrating films based on the electrospun nanofibrous web of PVA/prednisolone sodium phosphate blends, which have also shown potential for masking the unpleasant taste of prednisolone.…”

Section: Introductionmentioning

confidence: 99%

“…The limited bioavailability arising with the low water solubility of prednisolone also results in the side effects including gastric irritation, osteoporosis, diabetes, and hypertension. − On the other hand, there are a remarkable number of studies in the literature where the side effects of prednisolone have been eliminated by forming ICs with different types of CDs. ,− In these studies, it has been demonstrated that the aqueous solubility and so the bioavailability and the therapeutic potential of prednisolone can be enhanced by inclusion complexation. ,− Even, Basu et al have reported the masked bitter taste of prednisolone obtained by the inclusion complexation with βCD in the tablet that they developed as a mouth-dissolving formulation . The electrospinning of prednisolone incorporated nanofibrous webs has been also studied for the purpose of a sustained and fast release . In one of these related studies, Tawfik et al have generated orally disintegrating films based on the electrospun nanofibrous web of PVA/prednisolone sodium phosphate blends, which have also shown potential for masking the unpleasant taste of prednisolone .…”

Section: Introductionmentioning

confidence: 99%

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Orally Fast Disintegrating Cyclodextrin/Prednisolone Inclusion-Complex Nanofibrous Webs for Potential Steroid Medications

et al. 2021

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Prednisolone is a widely used immunosuppressive and anti-inflammatory drug type that suffers from low aqueous solubility and bioavailability. Due to the inclusion complexation with cyclodextrins (CDs), prednisolone's drawbacks that hinder its potential during the administration can be eliminated effectively. Here, we have early shown the electrospinning of free-standing nanofibrous webs of CD/prednisolone inclusion complexes (ICs) in the absence of a polymer matrix. In this study, hydroxypropylbeta-CD (HPβCD) has been used to form ICs with prednisolone and generate nanofibrous webs with a drug loading capacity of ∼10% (w/w). Pullulan/prednisolone nanofibrous webs have been also fabricated as a control sample having the same drug loading (∼10%, w/w). It has been demonstrated that prednisolone has been found in an amorphous state in the HPβCD/prednisolone nanofibrous web due to inclusion complexation, while it has retained its crystal structure in the pullulan/prednisolone nanofibrous web. Therefore, the HPβCD/prednisolone IC nanofibrous web has shown a faster and enhanced release profile and superior disintegration feature in artificial saliva than the pullulan/ prednisolone nanofibrous web. The complexation energy calculated using ab initio modeling displayed a more favorable interaction between HPβCD and prednisolone in the case of a molar ratio of 2:1 than 1:1 (CD: drug). Here, the HPβCD/prednisolone IC nanofibrous web has been developed without using a toxic component or solvent to dissolve drug molecules and boost drug loading in amorphous nature. The investigation of IC nanofibrous webs has been conducted to formulate a promising alternative to the orally disintegrating tablet formulation of prednisolone in the market. The nanofibrous structure and the improved physicochemical properties of prednisolone arising with the complexation might ensure a faster disintegration and onset of action against commercially available and orally disintegrating delivery systems during the desired treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Orally Fast Disintegrating Cyclodextrin/Prednisolone Inclusion-Complex Nanofibrous Webs for Potential Steroid Medications

et al. 2021

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“…In this review, we summarize the various aliphatic polyester-based nanofibers, in particular those of biomedically relevant polymers, such as poly(ε-caprolactone) (PCL) and poly (lactic acid) (PLA), whose properties have been modified by either CDs or CD-inclusion complexes (CD-ICs), and that have been reported in the past decade. Although other biomedically relevant polymers, such as chitosan [25,26] and poly(butylene succinate- co -terephthalate) (PBST) [27], have also been modified with CDs or ICs. As those studies are far fewer, they are not addressed in this manuscript.…”

Section: Introductionmentioning

confidence: 99%

Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes

et al. 2018

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The fabrication of nanofibers by electrospinning has gained popularity in the past two decades; however, only in this decade, have polymeric nanofibers been functionalized using cyclodextrins (CDs) or their inclusion complexes (ICs). By combining electrospinning of polymers with free CDs, nanofibers can be fabricated that are capable of capturing small molecules, such as wound odors or environmental toxins in water and air. Likewise, combining polymers with cyclodextrin-inclusion complexes (CD-ICs), has shown promise in enhancing or controlling the delivery of small molecule guests, by minor tweaking in the technique utilized in fabricating these nanofibers, for example, by forming core–shell or multilayered structures and conventional electrospinning, for controlled and rapid delivery, respectively. In addition to small molecule delivery, the thermomechanical properties of the polymers can be significantly improved, as our group has shown recently, by adding non-stoichiometric inclusion complexes to the polymeric nanofibers. We recently reported and thoroughly characterized the fabrication of polypseudorotaxane (PpR) nanofibers without a polymeric carrier. These PpR nanofibers show unusual rheological and thermomechanical properties, even when the coverage of those polymer chains is relatively sparse (~3%). A key advantage of these PpR nanofibers is the presence of relatively stable hydroxyl groups on the outer surface of the nanofibers, which can subsequently be taken advantage of for bioconjugation, making them suitable for biomedical applications. Although the number of studies in this area is limited, initial results suggest significant potential for bone tissue engineering, and with additional bioconjugation in other areas of tissue engineering. In addition, the behaviors and uses of aliphatic polyester nanofibers functionalized with CDs and CD-ICs are briefly described and summarized. Based on these observations, we attempt to draw conclusions for each of these combinations, and the relationships that exist between their presence and the functional behaviors of their nanofibers.

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“…In general, CS is known to have gelation properties, although not high. In a previous study, we reported that chitin nanofibers formed strong elastic gels with SBE-β-CD [28,29]. Therefore, these results indicate that the gelation that was observed on the surface of SD-CS/SBE-β-CD tablets after exposure to water, which functioned as a barrier to water penetration, caused the drug release to decelerate.…”

Section: Resultsmentioning

confidence: 62%

Design and Evaluation of An Extended-Release Olmesartan Tablet Using Chitosan/Cyclodextrin Composites

et al. 2019

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Sustained-release olmesartan tablets (OLM) were prepared by the simple, direct compression of composites of anionic sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and cationic spray-dried chitosan (SD-CS), and were evaluated for use as a sustained release preparation for the treatment of hypertension. An investigation of the interaction between OLM and SBE-β-CD by the solubility method indicated that the phase diagram of the OLM/SBE-β-CD system was the AL type, indicating the formation of a 1:1 inclusion complex. The release of OLM from tablets composed of the SD-CS/SBE-β-CD composite was slow in media at both pH 1.2 and at 6.8. The in vitro slow release characteristics of the SD-CS/SBE-β-CD composite were reflected in the in vivo absorption of the drug after normal rats were given an oral administration of the preparation. Furthermore, the SD-CS/SBE-β-CD composite continuously increased the antihypertensive effect of OLM in hypertensive rats, compared with that of the drug itself. These results suggest that a simple mixing of SD-CS and SBE-β-CD can be potentially useful for the controlled release of a drug for the continuous treatments of hypertension.

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Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease

Cited by 18 publications

References 36 publications

Orally Fast Disintegrating Cyclodextrin/Prednisolone Inclusion-Complex Nanofibrous Webs for Potential Steroid Medications

Orally Fast Disintegrating Cyclodextrin/Prednisolone Inclusion-Complex Nanofibrous Webs for Potential Steroid Medications

Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes

Design and Evaluation of An Extended-Release Olmesartan Tablet Using Chitosan/Cyclodextrin Composites

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