Surface cleaning in thin film technology

Mattox, Donald M.

doi:10.1016/0040-6090(78)90376-0

Cited by 57 publications

(8 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regardless of coating formulation, the contact angles on washed Ti plates were much larger than those on plasma-cleaned Ti plates, suggesting that the process of washing produced a relatively hydrophobic surface, whereas plasma cleaning gave rise to a very hydrophilic surface. Surface wettability (i.e., the degree of surface energy and hydrophilicity) is a good indication of the amount of contamination by hydrophobic organic impurities [28], Therefore, contact angle measurements indicate that plasma cleaning is more effective at removing contaminants from the Ti surface than washing with organic solvents, consistent with previous findings [29]. …”

Section: Resultssupporting

confidence: 84%

Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles

Choi

Bondy

Yoo

et al. 2013

Journal of Controlled Release

View full text Add to dashboard Cite

Immunization using a microneedle patch coated with vaccine offers the promise of simplified vaccination logistics and increased vaccine immunogenicity. This study examined the stability of influenza vaccine during the microneedle coating process, with a focus on the role of coating formulation excipients. Thick, uniform coatings were obtained using coating formulations containing a viscosity enhancer and surfactant, but these formulations retained little functional vaccine hemagglutinin (HA) activity after coating. Vaccine coating in a trehalose-only formulation retained about 40 – 50% of vaccine activity, which is a significant improvement. The partial viral activity loss observed in the trehalose-only formulation was hypothesized to come from osmotic pressure-induced vaccine destabilization. We found that inclusion of a viscosity enhancer, carboxymethyl cellulose, overcame this effect and retained full vaccine activity on both washed and plasma-cleaned titanium surfaces. The addition of polymeric surfactant, Lutrol® micro 68, to the trehalose formulation generated phase transformations of the vaccine coating, such as crystallization and phase separation, which was correlated to additional vaccine activity loss, especially when coating on hydrophilic, plasma-cleaned titanium. Again, the addition of a viscosity enhancer suppressed the surfactant-induced phase transformations during drying, which was confirmed by in vivo assessment of antibody response and survival rate after immunization in mice. We conclude that trehalose and a viscosity enhancer are beneficial coating excipients, but the inclusion of surfactant is detrimental to vaccine stability.

show abstract

Section: Resultssupporting

confidence: 84%

Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles

Choi

Bondy

Yoo

et al. 2013

Journal of Controlled Release

View full text Add to dashboard Cite

show abstract

“…In earlier work in which plasma cleaning was used in areas other than biomaterials, the following factors were found to be important for optimal cleanliness 19,[36][37][38] : 1) clean preparation systems with a low base pressure (<10 −5 Pa) and proper nongassing materials, 2) (ultra) clean process gases, 3) a system configuration without direct line of sight between the sample and foreign materials, 4) sufficient gas flow (turnover of process gas), and 5) surface passivation prior to exposure to uncontrolled atmospheres.…”

Section: Introductionmentioning

confidence: 99%

Glow discharge plasma treatment for surface cleaning and modification of metallic biomaterials

Aronsson

Lausmaa

Kasemo

1997

J. Biomed. Mater. Res.

107

View full text Add to dashboard Cite

Glow discharge plasma treatment is a frequently used method for cleaning, preparation, and modification of biomaterial and implant surfaces. The merits of such treatments are, however, strongly dependent on the process parameters. In the present work the possibilities, limitations, and risks of plasma treatment for surface preparation of metallic materials are investigated experimentally using titanium as a model system, and also discussed in more general terms. Samples were treated by different low-pressure direct current plasmas and analyzed using Auger electron spectroscopy (AES), x-ray photoelectron spectroscopy (XPS), atomic force microscopy, scanning electron microscopy, and light microscopy. The plasma system is a home-built, ultra-high vacuum-compatible system that allows sample introduction via a load-lock, and precise control of pressure, gas composition and flow rate, etc. This system allows uniform treatment of cylindrical and screw-shaped samples. With appropriate plasma parameters, argon plasma remove all chemical traces from former treatments (adsorbed contaminants and other impurities, and native oxide layers), in effect producing cleaner and more well-controlled surfaces than with conventional preparation methods. Removal (sputtering) rates up to 30 nm/min are possible. However, when inappropriate plasma parameters are used, the result may be increased contamination and formation of unintentional or undesired surface layers (e.g., carbides and nitrides). Plasma-cleaned surfaces provide a clean and reproducible starting condition for further plasma treatments to form well-controlled surface layers. Oxidation in pure O 2 (thermally or in oxygen plasmas) results in uniform and stoichiometric TiO 2 surface oxide layers of reproducible composition and thicknesses in the range 0.5-150 nm, as revealed by AES and XPS analyses. Titanium nitride layers were prepared by using N 2 plasmas. While mild plasma treatments leave the surface microstructure unaffected, heavy plasma treatment can give rise to dramatic morphologic changes.Comparison of these results with corresponding analyses of commercial implants and electropolished and/or anodically oxidized samples shows that the plasma treatment offers superior control of the surface status. However, it is also shown that improper control of the plasma process can produce unwanted and irreproducible results.

show abstract

“…[26] After drying with nitrogen, the two halves were then exposed to an oxygen plasma for 2 min. After plasma treatment, the two halves were brought together under a stream of deionized pure water, and then visually inspected for the presence of air bubbles between the glass plates.…”

Section: Methodsmentioning

confidence: 99%

Microdialysis Sampling Coupled to Microchip Electrophoresis with Integrated Amperometric Detection on an All‐Glass Substrate

2013

View full text Add to dashboard Cite

The development of an all-glass separation-based sensor using microdialysis coupled to microchip electrophoresis with amperometric detection is described. The system includes a flow-gated interface to inject discrete sample plugs from the microdialysis perfusate into the microchip electrophoresis system. Electrochemical detection was accomplished with a platinum electrode in an in-channel configuration using a wireless electrically isolated potentiostat. To facilitate bonding around the in-channel electrode, a fabrication process was employed that produced a working and a reference electrode flush with the glass surface. Both normal and reversed polarity separations were performed with this sensor. The system was evaluated in vitro for the continuous monitoring of the production of hydrogen peroxide from the reaction of glucose oxidase with glucose. Microdialysis experiments were performed using a BASi loop probe with an overall lag time of approximately five minutes and a rise time of less than 60 seconds.

show abstract

Surface cleaning in thin film technology

Cited by 57 publications

References 58 publications

Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles

Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles

Glow discharge plasma treatment for surface cleaning and modification of metallic biomaterials

Microdialysis Sampling Coupled to Microchip Electrophoresis with Integrated Amperometric Detection on an All‐Glass Substrate

Contact Info

Product

Resources

About