Surface chemistry influences cancer killing effect of TiO2 nanoparticles

Thevenot, Paul; Cho, Jai; Wavhal, Dattatray S.; Timmons, Richard B.; Tang, Liping

doi:10.1201/b22358-16

Cited by 8 publications

(13 citation statements)

References 1 publication

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“…It has been solidly established that shortly after implantation biomaterials are covered with a thin layer of host proteins, and it is believed that the state of adsorbed proteins play a key role in scaffold colonization from cells [37]. Therefore, controlling the amount, composition and conformation of adsorbed proteins is a viable approach to obtain a highly biocompatible surface [38]. In recent years, several strategies have been developed to guide protein adsorption and thus to improve cell adhesion, including immobilizing short fragment or proteins on scaffolds, or chemically and physically modifying scaffold surfaces.…”

Section: Modern Approaches To Enhance Scaffold Biocompatibilitymentioning

confidence: 99%

“…Chemical grafting has been used to improve hemocompatibility of vascular grafts by enriching them with heparin and polyethylene glycol (PEG or PEO). The drawbacks of this approach include the loss of protein mobility at the material surface, because they are covalently bound and the possible release of toxic monomers [38].…”

Section: Chemical and Physical Treatmentsmentioning

confidence: 99%

“…To overcome issues associated to chemical graft deposition, self-assembled monolayers (SAMs) were developed. SAMs was widely used to study in vivo responses of implanted biomaterials in the past, although nowadays is limited to gold-and silver-coated surfaces [38,43,44].…”

Section: Chemical and Physical Treatmentsmentioning

confidence: 99%

“…Plasma is considered the fourth state of matter and it is obtained when gases are excited by specific electromagnetic frequencies. Plasma modification is cheap and seems to be very effective, but it is still being currently investigated for the development of biomedical devices, including metals, polymers, and ceramics [38,45].…”

Section: Chemical and Physical Treatmentsmentioning

confidence: 99%

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Aptamer-Mediated Selective Protein Affinity to Improve Scaffold Biocompatibility

Parisi¹,

Galli²,

Elviri³

et al. 2016

Advanced Techniques in Bone Regeneration

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Protein adsorption on surfaces occurs shortly after scaffold insertion. This process is of pivotal importance to achieve therapeutic success in tissue engineering (TE), and favorable proteins should be adsorbed at the interface without unfolding to preserve their structure and function. Protein misfolding at the interface is a common phenomenon, which can impair cell adhesion and scaffold colonization. Many efforts have been done to improve scaffold biocompatibility by ameliorating protein adsorption, but with poor results. In the present chapter, we propose the use of a novel class of molecules, aptamers, to improve scaffold biocompatibility. Aptamers are small, single stranded oligonucleotides, which specifically bind to a target molecule: they work as antibodies, but without many of the drawbacks associated to the use of antibodies. We propose to immobilize aptamers on scaffolds to retain specific proteins, acting as docking points to guide cell activity. In particular, we show the results obtained by enriching different polymeric scaffolds with aptamers against human fibronectin, a naturally abundant protein in tissues, which plays a pivotal role in cell adhesion. We demonstrate that scaffold enrichment with aptamers lead to a better colonization of the substrate from cells. The results we obtained pave the way to the possibility of further investigating the role of aptamers as useful molecules to improve scaffold biocompatibility in the contest of tissue engineering.

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Section: Modern Approaches To Enhance Scaffold Biocompatibilitymentioning

confidence: 99%

Section: Chemical and Physical Treatmentsmentioning

confidence: 99%

Section: Chemical and Physical Treatmentsmentioning

confidence: 99%

Section: Chemical and Physical Treatmentsmentioning

confidence: 99%

See 2 more Smart Citations

Aptamer-Mediated Selective Protein Affinity to Improve Scaffold Biocompatibility

Parisi¹,

Galli²,

Elviri³

et al. 2016

Advanced Techniques in Bone Regeneration

View full text Add to dashboard Cite

show abstract

“…Several types of nano particles and their derivatives have received great attention for their potential antimicrobial effects. Metal nano particles such as Ag, silver oxide [13] Cerium oxide NPs increased oxidative stress and apoptosis in irradiated cancer cells, while protecting normal tissues [14][15].Titanium dioxide [16][17][18], silicon [19], copper oxide [20][21][22], zinc oxide [23][24][25], Au, calcium oxide [26] and magnesium oxide (MgO) [27] were identified to exhibit antimicrobial activity. In vitro studies revealed that metal nano particles inhibited several microbial species.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Cubi2o4 Nanoparticles and Evaluation of Its Antibacterial and Anticancer Activity

Jagadeesh,

Ch,

Kumar

et al. 2019

IJEAT

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CuBi2O4 nanoparticles (NPs) were prepared by Co-precipitation strategy and portrayed by UV–noticeable spectroscopy, X-beam diffraction (XRD), Fourier Transform Infrared (FT-IR), Scanning Electron Microscope (SEM) and Energy Dispersive Spectroscopy (EDS) examination. The blended NPs were exceptionally steady, circular and crystallite size was determined as 68.29 nm. In addition, hydroxyl radicals have been recognized in the photocatalytic response blend by utilizing Terephthalic acid in photoluminescence testing method. The proficiency of antibacterial movement of CuBi2O4 NPs was assessed against Escherichia Coli (MTCC-443).The cytotoxicity action of CuBi2O4 NPs was assessed by Sulforhodamine B (SRB) measure against A549 lung malignant growth cell lines and affirmed that CuBi2O4 NPs have cytotoxicity action.

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Electroconductive Collagen‐Carbon Nanodots Nanocomposite Elicits Neurite Outgrowth, Supports Neurogenic Differentiation and Accelerates Electrophysiological Maturation of Neural Progenitor Spheroids

Lomboni,

Ozgun,

de Medeiros

et al. 2023

Adv Healthcare Materials

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Neuronal disorders are characterized by the loss of functional neurons and disrupted neuroanatomical connectivity, severely impacting the quality of life of patients. This study investigates a novel electroconductive nanocomposite consisting of glycine‐derived carbon nanodots (GlyCNDs) incorporated into a collagen matrix and validates its beneficial physicochemical and electro‐active cueing to relevant cells. To this end, this work employs mouse induced pluripotent stem cell (iPSC)‐derived neural progenitor (NP) spheroids. The findings reveal that the nanocomposite markedly augmented neuronal differentiation in NP spheroids and stimulate neuritogenesis. In addition, this work demonstrates that the biomaterial‐driven enhancements of the cellular response ultimately contribute to the development of highly integrated and functional neural networks. Lastly, acute dizocilpine (MK‐801) treatment provides new evidence for a direct interaction between collagen‐bound GlyCNDs and postsynaptic N‐methyl‐D‐aspartate (NMDA) receptors, thereby suggesting a potential mechanism underlying the observed cellular events. In summary, the findings establish a foundation for the development of a new nanocomposite resulting from the integration of carbon nanomaterials within a clinically approved hydrogel, toward an effective biomaterial‐based strategy for addressing neuronal disorders by restoring damaged/lost neurons and supporting the reestablishment of neuroanatomical connectivity.

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Surface chemistry influences cancer killing effect of TiO2 nanoparticles

Cited by 8 publications

References 1 publication

Aptamer-Mediated Selective Protein Affinity to Improve Scaffold Biocompatibility

Aptamer-Mediated Selective Protein Affinity to Improve Scaffold Biocompatibility

Synthesis and Characterization of Cubi2o4 Nanoparticles and Evaluation of Its Antibacterial and Anticancer Activity

Electroconductive Collagen‐Carbon Nanodots Nanocomposite Elicits Neurite Outgrowth, Supports Neurogenic Differentiation and Accelerates Electrophysiological Maturation of Neural Progenitor Spheroids

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