Surface charge transition nano-theranostics based on ultra-small Fe3O4 nanoparticles for enhanced photodynamic and photothermal therapy against nasopharyngeal carcinoma

Bejjanki, Naveen Kumar; Zhong, Ying; Liu, Jie; Li, Quanming; Xu, Hongfa; Shen, Hui; Xie, Mingxing

doi:10.1016/j.bbrc.2021.03.168

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…Photothermal therapeutic agents are also excellent photosensitizers, and the combination of PDT and PTT may have a synergistic effect on phototherapy. Bejjanki et al ( 192 ) studied the efficacy of PTT combined with PDT in treating tumors. They combined ICG, Fe3O4, and palmitoyl ascorbic acid (PA) with pH-responsive PEG-b-PAEMA-PDMA polymers to form nano-drug carriers.…”

Section: Application Of Ph-responsive Polymer Nanomaterials In Tumor ...mentioning

confidence: 99%

pH-Responsive Polymer Nanomaterials for Tumor Therapy

et al. 2022

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The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery systems can be constructed for targeted drug delivery to tumor sites. Among these, the pH is frequently utilized, owing to the pH of the tumor microenvironment being lower than that of blood and healthy tissues. pH-responsive polymer carriers can improve the efficiency of drug delivery in vivo, allow targeted drug delivery, and reduce adverse drug reactions, enabling multifunctional and personalized treatment. pH-responsive polymers have gained increasing interest due to their advantageous properties and potential for applicability in tumor therapy. In this review, recent advances in, and common applications of, pH-responsive polymer nanomaterials for drug delivery in cancer therapy are summarized, with a focus on the different types of pH-responsive polymers. Moreover, the challenges and future applications in this field are prospected.

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Section: Application Of Ph-responsive Polymer Nanomaterials In Tumor ...mentioning

confidence: 99%

pH-Responsive Polymer Nanomaterials for Tumor Therapy

et al. 2022

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“…In 2021, Naveen et al developed acidic surface-charge transformable nanoclusters (NCs) composed of indocyanine green (ICG), Fe3O4, and palmitoyl ascorbic acid with pH-responsive PEG-b-PAEMAPDMA for enhanced synergistic PDT/PTT. 84 The results revealed that NCs could be used as “all in one” nanotheranostic agent for enhanced PDT/PTT of NPC therapy. Zhong et al successfully synthesized an efficient multifunctional nanocluster (NPs FA-PEG/CBT@ SPION-ICG) and enhanced the targeting and aggregation efficiency for PTT and PDT.…”

Section: Optical Treatment Strategies For Npcmentioning

confidence: 95%

Multi-Modal Optical Imaging and Combined Phototherapy of Nasopharyngeal Carcinoma Based on a Nanoplatform

Lin¹,

Qiu²,

Lan³

et al. 2022

IJN

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Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck with a high incidence rate worldwide, especially in southern China. Phototheranostics in combination with nanoparticles is an integrated strategy for enabling simultaneous diagnosis, real-time monitoring, and administration of precision therapy for nasopharyngeal carcinoma (NPC). It has shown great potential in the field of cancer diagnosis and treatment owing to its unique noninvasive advantages. Many Chinese and international research teams have applied nano-targeted drugs to optical diagnosis and treatment technology to conduct multimodal imaging and collaborative treatment of NPC, which has become a hot research topic. In this review, we aimed to introduce the recent developments in phototheranostics of NPC based on a nanoplatform. This study aimed to elaborate on the applications of nanoplatform-based optical imaging strategies and treatment modalities, including fluorescence imaging, photoacoustic imaging, Raman spectroscopy imaging, photodynamic therapy, and photothermal therapy. This study is expected to provide a scientific basis for further research and development of NPC diagnosis and treatment.

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“…These free-moving photoinduced electrons and holes with redox abilities can, respectively, react with the surrounding O 2 and water molecules under certain potential conditions to produce the killing superoxide anion (•O 2 -) radicals and O 2 [9]. Moreover, as a primary ROS, •O 2 can be further transformed into a series of ROS with stronger tumor-killing property, such as hydrogen peroxide (H 2 O 2 ) and hydroxyl (•OH) radicals [10]. •O 2 radicals are produced through the type I PDT mechanism by the electron transfer pathway, whereas most PSs are based on the type II PDT mechanism, in which energy transfers to O 2 in adjacent tissues to generate toxic singlet oxygen ( 1 O 2 ) [11].…”

Section: Introductionmentioning

confidence: 99%

Bi2S3/Ti3C2-TPP Nano-Heterostructures Induced by Near-Infrared for Photodynamic Therapy Combined with Photothermal Therapy on Hypoxic Tumors

Jiang,

Sun,

Liu

et al. 2024

Preprint

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Background Photodynamic therapy (PDT) efficacy of bismuth sulfide (Bi2S3) semiconductor has been severely restricted by its electron–hole pairs (e−−h+) separation inefficiency and oxygen (O2) deficiency in tumors, which greatly hinders reactive oxygen species (ROS) generation and further clinical application of Bi2S3 nanoparticles (NPs) in biomedicine. Results Herein, novel Bi2S3/titanium carbide (Ti3C2) two-dimensional nano-heterostructures (NHs) are designed to realize multimode PDT of synchronous O2 self-supply and ROS generation combined with highly eﬃcient photothermal tumor elimination for hypoxic tumor therapy. Bi2S3/Ti3C2 NHs were synthesized via the in situ synthesis method starting from Ti3C2 nanosheets (NSs), a classical type of MXene nanostructure. Compared to simple Bi2S3 NPs, Bi2S3/Ti3C2 NHs signiﬁcantly extend the absorption to the near-infrared (NIR) region and enhance the photocatalytic activity owing to the improved photogenerated carrier separation, where the hole on the valence band (VB) of Bi2S3 can react with water to supply O2 for the electron on the Ti3C2 NSs to generate ·O2− and ·OH through electron transfer. Furthermore, they also achieve 1O2 generation through energy transfer due to O2 self-supply. After the modification of triphenylphosphium bromide (TPP) on Bi2S3/Ti3C2 NHs, systematic in vitro and in vivo evaluations were conducted, revealing that the synergistic-therapeutic outcome of this nanoplatform enables complete eradication of the U251 tumors without recurrence by NIR laser irradiation, and it can be used for computed tomography (CT) imaging because of the strong X-ray attenuation ability. Conclusion This work expands the phototherapeutic effect of Bi2S3-based nanoplatforms, providing a new strategy for hypoxic tumor theranostics.

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Surface charge transition nano-theranostics based on ultra-small Fe3O4 nanoparticles for enhanced photodynamic and photothermal therapy against nasopharyngeal carcinoma

Cited by 12 publications

References 12 publications

pH-Responsive Polymer Nanomaterials for Tumor Therapy

pH-Responsive Polymer Nanomaterials for Tumor Therapy

Multi-Modal Optical Imaging and Combined Phototherapy of Nasopharyngeal Carcinoma Based on a Nanoplatform

Bi2S3/Ti3C2-TPP Nano-Heterostructures Induced by Near-Infrared for Photodynamic Therapy Combined with Photothermal Therapy on Hypoxic Tumors

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