Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

Yuan, Youyong; Mao, Chengqiong; Du, Xiao-Jiao; Du, Jin‐Zhi; Wang, Rui; Wang, Jun

doi:10.1002/adma.201202296

Cited by 464 publications

(350 citation statements)

References 41 publications

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“…The successful biomedical application of a nanomaterial is a reflection of its adequate design. Several factors should be taken into account such as size [13][14][15], shape [16], surface charge [17] and surface modification [18], to list but a few. Regarding surface modification (e.g., coating [13]), coating the nanomaterial with a polymeric coating reduces protein adsorption to nanomaterial surface and subsequently can reduce the nanomaterial clearance from the circulation through opsonization process.…”

Section: Introductionmentioning

confidence: 99%

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

et al. 2017

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Aim:To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T 2 magnetic resonance contrast agent and their uptake and toxicity in liver. Materials & methods: Mice were intravenously injected with bioferrofluids and Endorem R . The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Results: Bioferrofluids are a good T 2 contrast agent with a higher r 2 /r 1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Conclusion: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.Lay abstract: Several superparamagnetic iron oxide nanoparticles (SPIONs) preparations have been approved by US FDA for clinical use as MRI contrast agents. In recent years, we have been developing a synthetic multifunctional platform for SPIONs based on the use of polymers. In this report, we explored the diagnostic potential of these nanoparticles (herein called bioferrofluids) as an MRI contrast agent and their uptake in liver, without neglecting their toxicological effects. Results show that our bioferrofluids are a good T 2 contrast agent without any observed toxicity in liver.

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Section: Introductionmentioning

confidence: 99%

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

et al. 2017

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“…. was no profound aggregation of dendritic conjugate in PBS with 50% FBS and dendritic conjugate exhibited much favorable serum stability for 24 h. The excellent stability of dendritic conjugate might be ascribed to the overall negative surface charge of dendritic conjugate that could minimize the interaction between dendritic conjugate and plasma proteins and prevent drug leakage during blood circulation. Moreover, the stability may prolong the blood circulation half-life and improve the efficiency in drug delivery into tumor tissues in vivo [37][38][39].…”

Section: Stability Of the Ph-sensitive Dendritic Conjugatementioning

confidence: 99%

Enzyme/pH-sensitive dendritic polymer-DOX conjugate for cancer treatment

et al. 2018

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It is in a great demand to design a biodegradable, tumor microenvironment-sensitive drug delivery system to achieve safe and highly efficacious treatment of cancer. Herein, a novel pH/enzyme sensitive dendritic pdiHPMA-DOX conjugate was designed. diHPMA dendritic copolymer with GFLG segments in the branches which are sensitive to the intracellular enzyme of the tumor was prepared through RAFT polymerization. DOX was attached to dendritic diHP-MA polymer through a pH-sensitive hydrazone bond. The dendritic pdiHPMA-DOX conjugate self-assembled into nanoparticles with an ideal spherical shape at a mean size of 103 nm. The DOX attached to the polymeric carrier was released in an acidic environment, and the GFLG linker for synthesizing the dendritic vehicle with a high molecular weight (M W , 220 kDa) was cleaved to release low M W segments (<40 kDa) in the presence of cathepsin B. The dendritic polymeric conjugate was internalized via an endocytic pathway, and then released the anticancer drug, which led to significant cytotoxicity for tumors. The blood circulation time was profoundly prolonged, resulting in high accumulation of DOX into tumors. In vivo anti-tumor experiments with 4T1 tumor bearing mice demonstrated that the conjugate had a better antitumor efficacy in comparison with free DOX. Additionally, body weight measurements and histological examinations indicated that the conjugate showed low toxicities to normal tissues. This dendritic polymeric drug carrier in a response to intracellular enzyme and acidic pH of tumor tissue or cells holds great promise in tumor-targeted therapy.

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“…[4][5][6] Moreover, the incorporation of specific functional groups on the vector provides a robust route to biomolecule conjugation 7 or surface charged modifications to generate neutral, anionic, cationic or zwitterionic species, which can both aid in the targeting of specific cell populations to limit systemic exposure. [8][9][10][11] Acute lymphoblastic leukaemia (ALL) is a disease with an incidence of 1 -4.75 per 100,000 people globally 12 , but with a much higher incidence in children, peaking at between 2 and 5 years of age.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Triblock Copolymer Vectors for the Treatment of Acute Lymphoblastic Leukemia

et al. 2017

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Accordingly, we describe the synthesis, characterisation and testing of a range of biocompatible triblock copolymer micelles as particle-based delivery vectors for the hydrophobic drug Parthenolide.The drug-loaded particles are produced via an emulsion-to-micelle transition method and the effects of introducing anionic and cationic surface charges on stability, drug sequestration, biocompatibility and efficacy are investigated. Significantly, we demonstrate high levels of efficacy in the organic solvent free systems against human mesenchymal stem cells and primary T-acute lymphoblastic leukaemia patient cells, highlighting the effectiveness of the delivery vectors for the treatment of acute lymphoblastic leukaemia.3

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Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

Cited by 464 publications

References 41 publications

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Enzyme/pH-sensitive dendritic polymer-DOX conjugate for cancer treatment

Functionalized Triblock Copolymer Vectors for the Treatment of Acute Lymphoblastic Leukemia

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Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

Cited by 464 publications

References 41 publications

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T 2 Contrast Agent for MRI and their Uptake in Liver

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T 2 Contrast Agent for MRI and their Uptake in Liver

Enzyme/pH-sensitive dendritic polymer-DOX conjugate for cancer treatment

Functionalized Triblock Copolymer Vectors for the Treatment of Acute Lymphoblastic Leukemia

Contact Info

Product

Resources

About

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver