Surface characterization of a silicone hydrogel contact lens having bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer layer in hydrated state

Shi, Xinfeng; Cantu-Crouch, David; Sharma, Vinay; Pruitt, John; Yao, George C.; Fukazawa, Kyoko; Wu, James Yuliang; Ishihara, Kazuhíko

doi:10.1016/j.colsurfb.2020.111539

Cited by 32 publications

(58 citation statements)

References 46 publications

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“…[33,50,91] The wettability and tensile strength of the CL material were improved by chemically functionalized carbon nanoparticles, while retaining no cytotoxicity and exhibiting excellent impact resistance. [92] Other examples, such as titanium dioxide (TiO 2 ) nanoparticles, were also explored to increase the refractive index and maintain the high transparency of the SCL device. [93]…”

Section: Encapsulationmentioning

confidence: 99%

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

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Section: Encapsulationmentioning

confidence: 99%

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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“…In addition to this, the coefficient of friction was reduced and the interaction force of protein deposition was lowered. All these properties of hydrogel contact lenses make it an excellent ocular formulation for the treatment of various diseases [ 202 ]. A combination of two different classes of drugs, such as an antibiotic (moxifloxacin hydrochloride) and anti-inflammatory (diclofenac sodium), were utilized with silicone and other natural polymers such as hyaluronate, alginate, and poly-lysine to prepare contact lens hydrogel.…”

Section: Potential Applications Of Hydrogel In the Biomedical Sectormentioning

confidence: 99%

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

et al. 2022

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Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.

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“…73 The ocular silicon hydrogels for long-term hydrated exposure are surface modified with the bioinspired PMC polymers. 74 The resulting product is applied as a contact lens as a result of the formation of a soft cross-linked biomaterial PMC layer onto the surface of a silicone film, which featured its exceptional lubricity (the coefficient of friction decreased by more than 80%), hydrophilicity (a higher bubble contact angle), suppression of protein expression (the interaction force between the biomaterial and protein decreased, leading to a very low possibility of protein deposition), and the mechanical flexibility (claimed, but not reported). The use of PMC for antifouling has been frequently reported in many previous papers, among which are regiospecifically controlled protein immobilization with immunoassay potential, 76 MPC/poly(vinyl chloride) (PVC) membranes with exceptional resistance to organic fouling and biofouling characteristics, 77 and zwitterionic PMC brush functionalized PDMS membranes aimed at antifouling and wound dressing.…”

Section: Biomedical Applications Of Phospholipidmentioning

confidence: 99%

“…For instance, zwitterionic MPC-grafted polymer brushes with the size smaller than 10 nm were used to modify the surface of poly(dimethylsiloxane) (PDMS) contact lenses presenting exceptional hydrophilicity and antifouling resistance with the aid of an atmospheric plasma-induced polymerization reaction by changing the composition of the plasma (O 2 , N 2 , and Ar) . The ocular silicon hydrogels for long-term hydrated exposure are surface modified with the bioinspired PMC polymers . The resulting product is applied as a contact lens as a result of the formation of a soft cross-linked biomaterial PMC layer onto the surface of a silicone film, which featured its exceptional lubricity (the coefficient of friction decreased by more than 80%), hydrophilicity (a higher bubble contact angle), suppression of protein expression (the interaction force between the biomaterial and protein decreased, leading to a very low possibility of protein deposition), and the mechanical flexibility (claimed, but not reported).…”

Section: Biomedical Applications Of Phospholipid Nanobiomaterialsmentioning

confidence: 99%

Emerging Phospholipid Nanobiomaterials for Biomedical Applications to Lab-on-a-Chip, Drug Delivery, and Cellular Engineering

Rahimnejad

Rabiee

Ahmadi

et al. 2021

ACS Appl. Bio Mater.

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The design of advanced nanobiomaterials to improve analytical accuracy and therapeutic efficacy has become an important prerequisite for the development of innovative nanomedicines. Recently, phospholipid nanobiomaterials including 2-methacryloyloxyethyl phosphorylcholine (MPC) have attracted great attention with remarkable characteristics such as resistance to nonspecific protein adsorption and cell adhesion for various biomedical applications. Despite many recent reports, there is a lack of comprehensive review on the phospholipid nanobiomaterials from synthesis to diagnostic and therapeutic applications. Here, we review the synthesis and characterization of phospholipid nanobiomaterials focusing on MPC polymers and highlight their attractive potentials for applications in micro/nanofabricated fluidic devices, biosensors, lab-on-a-chip, drug delivery systems (DDSs), COVID-19 potential usages for early diagnosis and even treatment, and artificial extracellular matrix scaffolds for cellular engineering.

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Surface characterization of a silicone hydrogel contact lens having bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer layer in hydrated state

Cited by 32 publications

References 46 publications

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

Emerging Phospholipid Nanobiomaterials for Biomedical Applications to Lab-on-a-Chip, Drug Delivery, and Cellular Engineering

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