Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

Grenadyorov, A. S.; Zhulkov, М. О.; Solovyev, A. A.; Оскомов, К. В.; Semenov, V. A.; Chernyavskiy, Alexander; Сирота, Д. А.; Кармадонова, Н. А.; Малащенко, В. В.; Литвинова, Л. С.; Хазиахматова, О. Г.; Газатова, Н. Д.; Хлусов, И. А.

doi:10.1016/j.msec.2021.112002

Cited by 11 publications

(12 citation statements)

References 48 publications

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“…In our research, PACVD of the a-C:H:SiO x film onto the AISI 316L stainless steel significantly reduces their corrosion rate in a solution of 0.5 M NaCl [50]. A more significant reduction in the corrosion rate is observed for the a-C:H:SiO x film deposited onto the Ti-6Al-4V alloy surface, when exposed to 0.5 M NaCl and PBS binding buffer at 22 and 37 • C, respectively [31]. In the experiment with Ti-6Al-4V substrates, their five-week in vitro biodegradation in a solution of 0.9% NaCl is accompanied by the salt precipitation (see Tables S1 and S2, Supplementary materials) onto the surface (see Figure 7 and Table 5).…”

Section: Discussionmentioning

confidence: 88%

“…Early research [41] documented that zeta potential of thin films and further ion precipitation were affected by the electrostatic surface charge. In [31], we proved that a-C:H:SiO x films possessed the negative surface potential in air; its amplitude grew with elevating thickness of the a-C:H:SiO x coating on titanium, silicon, and steel substrates [50]. At the same time, Spearman's rank correlation showed that the growth in the a-C:H:SiO x film thickness prevented Na + precipitation (r S = −0.73-0.75, p < 0.001, n = 40) rather than Cl − precipitation (r S = −0.30-0.33, p > 0.05, n = 40).…”

Section: Discussionmentioning

confidence: 99%

“…Our previous research [28][29][30] reports on the effect from these parameters on different properties of the a-C:H:SiOx film. In our experiment, the a-C:H:SiOx film deposition is performed in optimum conditions, which provide the formation of hard, wear-resistant, and biocompatible coatings [31,32]. In PACVD, the process pressure is 0.1 Pa at the argon gas rate of 4 ± 0.1 L/h and PPMS consumption rate of 0.8 ± 0.05 mL/h.…”

Section: Preparation Of A-c:h:sio X Coatingsmentioning

confidence: 99%

“…The surface defects of as-deposited a-C:H:SiOx films and the Rockwell hardness were examined on a Polar-1 metallographic microscope (Mikromed, Moscow, Russia) in the reflected polarized light. In our experiment, the a-C:H:SiO x film deposition is performed in optimum conditions, which provide the formation of hard, wear-resistant, and biocompatible coatings [31,32]. In PACVD, the process pressure is 0.1 Pa at the argon gas rate of 4 ± 0.1 L/h and PPMS consumption rate of 0.8 ± 0.05 mL/h.…”

Section: Surface Characterizationmentioning

confidence: 99%

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In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

et al. 2022

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This paper focuses mainly on the in vitro study of a five-week biodegradation of a-C:H:SiOx films of different thickness, obtained by plasma-assisted chemical vapor deposition onto Ti-6Al-4V alloy substrate using its pulsed bipolar biasing. In vitro immersion of a-C:H:SiOx films in a solution of 0.9% NaCl was used. It is shown how the a-C:H:SiOx film thickness (0.5–3 µm) affects the surface morphology, adhesive strength, and Na+ and Cl− precipitation on the film surface from the NaCl solution. With increasing film thickness, the roughness indices are reducing a little. The adhesive strength of the a-C:H:SiOx films to metal substrate corresponds to quality HF1 (0.5 µm in thickness) and HF2-HF3 (1.5–3 µm in thickness) of the Rockwell hardness test (VDI 3198) that defines strong interfacial adhesion and is usually applied in practice. The morphometric analysis of the film surface shows that on a-C:H:SiOx-coated Ti-6Al-4V alloy surface, the area occupied by the grains of sodium chloride is lower than on the uncoated surface. The reduction in the ion precipitation from 0.9% NaCl onto the film surface depended on the elemental composition of the surface layer conditioned by the thickness growth of the a-C:H:SiOx film. Based on the results of energy dispersive X-ray spectroscopy, the multiple regression equations are suggested to explain the effect of the elemental composition of the a-C:H:SiOx film on the decreased Na+ and Cl− precipitation. As a result, the a-C:H:SiOx films successfully combine good adhesion strength and rare ion precipitation and thus are rather promising for medical applications on cardiovascular stents and/or friction parts of heart pumps.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Preparation Of A-c:h:sio X Coatingsmentioning

confidence: 99%

Section: Surface Characterizationmentioning

confidence: 99%

See 2 more Smart Citations

In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

et al. 2022

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“…To the best of our knowledge, there has been no research on the use of PACVD for deposition of the layer of fluoroorganic compounds on the surface of knitted polypropylene implants. Grendyorov, et al [ 22 ] performed a deposition of SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating onto the titanium (Ti-6Al-4V) alloy substrate using PACVD. The obtained materials supported surface endothelization of a titanium implant applied in direct blood contact and resulted in the absence of cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Design of New Concept of Knitted Hernia Implant

et al. 2022

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A knitted implant, unilaterally modified with plasma-assisted chemical-vapor deposition (PACVD), and with a nano-layer of fluorine derivative supplementation, for reducing the risk of complications related to adhesions, and the formation of a thick postoperative scar was prepared. The biological evaluation of designed or modified medical devices is the main aspect of preclinical research. If such studies use a medical device with prolonged contact with connective tissue (more than 30 days), biocompatibility studies require a safety assessment in terms of toxicity in vitro and in vivo, allergenicity, irritation, and cancerogenicity, reproductive and developmental toxicity. The ultimate aspect of biological evaluation is biofunctionality, and evaluation of the local tissue response after implantation, resulting in the determination of all aspects of local biocompatibility with the implemented synthetic material. The implantation of PACVD-modified materials in muscle allows us to estimate the local irritation effect on the connective tissue, determining the risk of scar formation, whereas implantation of the above-mentioned knitted fabric into the abdominal wall, assists with evaluating the risk of fistula formation—the main post-surgical complications. The research aimed to evaluate the local reaction of the soft tissues after the implantation of the knitted implants modified with PACVD of the fluoropolymer in the nanostuctural form. The local effect that occurred during the implantation of the designed implants was quantitatively and qualitatively evaluated when PACVD unmodified (reference), and modified medical devices were implanted in the abdominal cavity (intra-abdominal position) for 12 or into the muscles for 56 weeks. The comparative semi-quantitative histological assessment included the severity of inflammatory cells (multinucleated cells, lymphocytes, plasma cells, macrophages, giant cells) and the tissue response (necrosis, neovascularization, fibrosis, and fat infiltration) on a five-point scale. The knitted implants modified by PACVD did not indicate cumulative tissue response when they were implanted in the muscle and intra-abdominally with direct contact with the viscera. They reduced local tissue reaction (score −2.71 after 56 weeks of the implantation) and internal organ adhesion (irritation score −2.01 and adhesion susceptibility −0.3 after 12 weeks of the implantation) compared with the reference (unmodified by PACVD) knitted implant, which had an identical structure and was made of the same source.

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Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiO_x‐coated Ti–6Al–4V substrate

Grenadyorov

Solovyev

Оскомов

et al. 2022

J Biomedical Materials Res

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The article deals with the plasma‐assisted chemical vapor deposition of 0.3–1.4 μm thick a‐C:H:SiOx films in a mixture of argon and polyphenylmethylsiloxane vapor onto the Ti–6Al–4V alloy substrate, which is often used as an implant material. The a‐C:H:SiOx film structure is studied by the Fourier‐transform infrared and Raman spectroscopies. The pull‐off adhesion test assesses the adhesive strength of a‐C:H:SiOx films, and the ball‐on‐disk method is employed to measure their wear rate and friction coefficient. According to these studies, a‐C:H:SiOx films are highly adhesive to the Ti–6Al–4V substrate, have low (0.056) friction coefficient and wear rate (9.8 × 10−8 mm3 N−1 m−1) in phosphate‐buffered saline at 40°C. In vitro studies show neither thrombogenicity nor cytotoxicity of the a‐C:H:SiOx film for the human blood mononuclear cells (hBMNCs). The in vitro contact between the hBMNC culture and a‐C:H:SiOx films 0.8–1.4 μm thick deposited onto Ti–6Al–4V substrates reduces a 24‐hour secretion of pro‐inflammatory cytokines and chemokines IL‐8, IL‐17, TNFα, RANTES, and MCP‐1. This reduction is more significant when the film thickness is 1.4 μm and implies its potential anti‐inflammatory effect and possible application in cardiovascular surgery. The dependence is suggested for the concentration of anti‐inflammatory cytokines and chemokines and the a‐C:H:SiOx film thickness, which correlates with the surface wettability and electrostatic potential. The article discusses the possible applications of the anti‐inflammatory effect and low thrombogenicity of a‐C:H:SiOx films in cardiovascular surgery.

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Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

Cited by 11 publications

References 48 publications

In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

Design of New Concept of Knitted Hernia Implant

Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiO_x‐coated Ti–6Al–4V substrate

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Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

Cited by 11 publications

References 48 publications

In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

In Vitro Biodegradation of a-C:H:SiOx Films on Ti-6Al-4V Alloy

Design of New Concept of Knitted Hernia Implant

Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiOx‐coated Ti–6Al–4V substrate

Contact Info

Product

Resources

About

Morphofunctional reaction of leukocytes and platelets in in vitro contact with a‐C:H:SiO_x‐coated Ti–6Al–4V substrate