Surface characteristics influencing bacterial adhesion to polymeric substrates

Yuan, Yue; Hays, Michael P.; Hardwidge, Philip R.; Kim, Jooyoun

doi:10.1039/c7ra01571b

Cited by 342 publications

(281 citation statements)

References 40 publications

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“…However, we observed the opposite relationship between contact angle and surface smoothness when parylene was compared to polyurethane. This may imply that the bacterial resistance clearly observed in the experiment may be due to other material properties known to impact bacterial adhesion and biofilm formation, such as surface energy, surface charge, and surface topology 23 …”

Section: Discussionmentioning

confidence: 99%

Reduced bacterial adhesion with parylene coating: Potential implications for Micra transcatheter pacemakers

El‐Chami

Mayotte

Bonner

et al. 2020

Cardiovasc electrophysiol

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Introduction Infections of cardiac implantable electronic devices remain a prevalent health concern necessitating the advent of novel preventative strategies. Based on the observation that bacterial infections of the Micra transcatheter pacemaker device are extremely rare, we examine the effect of parylene coating on bacterial adhesion and growth. Methods Bacterial growth was compared on polyurethane coated, bare, or parylene coated titanium surfaces. Eight test samples per bacterial species and material combination were incubated with Staphylococcus Aureus or Pseudomonas aeruginosa for 24 hours and then assayed for bacterial growth. The surface contact angle was also characterized by measuring the angle between the tangent to the surface of a liquid droplet made with the surface of the solid sample. Results The mean bacterial colony counts were significantly reduced for both parylene coated titanium versus bare samples (3.69 ± 0.27 and 4.80 ± 0.48 log[CFU/mL] respectively for S. aureus [P < .001] and 5.51 ± 0.27 and 6.08 ± 0.11 log[CFU/mL] respectively for P. aeruginosa [P < .001]), and for parylene coated titanium versus polyurethane samples (4.27 ± 0.42 and 5.40 ± 0.49 log[CFU/mL] respectively for S. aureus [P < .001] and 4.23 ± 0.42 and 4.84 ± 0.32 log[CFU/mL] respectively for P. aeruginosa [P = .006]). Parylene coated titanium samples had a higher contact angle compared with bare titanium, but lower compared with polyurethane (mean contact angle 87.5 ± 3.1 degrees parylene, 73.3 ± 3.7 degrees titanium [P < .001 vs parylene], and 94.8 ± 3.7 degrees polyurethane [P = .002 vs parylene]). Conclusions Parylene coating significantly reduced the ability of bacteria to grow in colony count assays suggesting that this could contribute to the reduction of bacterial infections of Micra transcatheter pacemakers.

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Section: Discussionmentioning

confidence: 99%

Reduced bacterial adhesion with parylene coating: Potential implications for Micra transcatheter pacemakers

El‐Chami

Mayotte

Bonner

et al. 2020

Cardiovasc electrophysiol

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“…On the one hand, hydrolysis led to a higher surface hydrophilicity, as WCA measurements shown. This has been speculated to hinder bacterial adhesion by making decrease hydrophobic interactions and enhancing a substrate‐bacteria repulsion . On the other hand, hydrolysis implies the incorporation of negative surface charges that may result into reduced bacteria attachment, as a consequence of the electrostatic repulsion between E. coli , with an overall negative charge, and the functionalized substrates …”

Section: Resultsmentioning

confidence: 99%

Hydrolysis of poly(l‐lactide)/ZnO nanocomposites with antimicrobial activity

Pérez‐Álvarez

Lizundia

Ruiz‐Rubio

et al. 2019

J of Applied Polymer Sci

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This work investigates the effect of the incorporation of zinc oxide (ZnO) nanoparticles within a poly(L-lactic acid) (PLLA) matrix as an approach to speed up the hydrolysis of PLLA film surfaces. Hydrolysis was done by immersing nanocomposite films having 1 wt % of ZnO in 0.25 M sodium hydroxide at 58 C. This concentration has been selected as it provides the maximum changes of physicochemical properties of hosting PLLA matrix. The evolution of the thermal properties, ultraviolet-visible transparency, wettability, and morphology were monitored at different time points. The amount of carboxylic groups onto PLLA/ZnO surfaces was quantified according to Toludine Blue-O assay. Hydrolysis was mainly limited to film surfaces, which were grafted by carboxylic groups as a result of the random scission of PLLA ester linkages. The presence of such functional groups decreases the inherent surface hydrophobicity of PLLA at short hydrolysis times. On the contrary, long hydrolyses increase the hydrophobicity as a result of surface nanostructuring induced by the degradation of PLLA to water-soluble oligomers. Overall, ZnO nanoparticles enable shorter surface modification times and provide a quick approach for the modification on the polarity of polylactide surfaces. The potential of hydrolyzed films as antimicrobial materials was explored using Gram-negative Escherichia coli as a model. Accordingly, materials used for packaging applications should be transparent in the visible region at the same time that they display a good degradability, proper mechanical performance, low toxicity, environmentally benign characteristics, ultraviolet (UV)-shielding properties, antibacterial activity, and cost competitive characteristics. Polylactides (PLAs) fulfill the majority of those requirements and they represent one of the most remarkable examples of biopolymers able to replace petroleum-based materials. [1][2][3][4] PLAs are linear aliphatic polyesters that could be obtained from 100% renewable Additional Supporting Information may be found in the online version of this article.

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“…In addition to the surface energy, hydrophobicity of the substratum also appears to affect bacterial attachment. In a study carried out by Yuan et al, surfaces with moderate hydrophobicity (water contact angle of about 90°) were shown to lead to highest bacterial adhesion . In another study, Quirynen et al demonstrated that biofilms were found to form less on hydrophobic surfaces than on hydrophilic surfaces in oral environments .…”

Section: Device‐associated Infectionsmentioning

confidence: 99%

“…Although the trend was further confirmed in several other studies, it was primarily based on thermodynamics. The inability of the model to recognize the complexities of bacterial structures as well as specific interactions between materials and bacteria, such as those mediated by MSCRAMMs, have caused some deviations from the model prediction …”

Section: Device‐associated Infectionsmentioning

confidence: 99%

Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces

Shi

Wang

et al. 2018

Adv Healthcare Materials

168

108

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With the rapid spreading of resistance among common bacterial pathogens, bacterial infections, especially antibiotic-resistant bacterial infections, have drawn much attention worldwide. In light of this, nanoparticles, including metal and metal oxide nanoparticles, liposomes, polymersomes, and solid lipid nanoparticles, have been increasingly exploited as both efficient antimicrobials themselves or as delivery platforms to enhance the effectiveness of existing antibiotics. In addition to the emergence of widespread antibiotic resistance, of equal concern are implantable device-associated infections, which result from bacterial adhesion and subsequent biofilm formation at the site of implantation. The ineffectiveness of conventional antibiotics against these biofilms often leads to revision surgery, which is both debilitating to the patient and expensive. Toward this end, micro- and nanotopographies, especially those that resemble natural surfaces, and nonfouling chemistries represent a promising combination for long-term antibacterial activity. Collectively, the use of nanoparticles and nanostructured surfaces to combat bacterial growth and infections is a promising solution to the growing problem of antibiotic resistance and biofilm-related device infections.

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Surface characteristics influencing bacterial adhesion to polymeric substrates

Abstract: Effective surface area on rough substrates for bacterial adhesion is examined by analyzing the solid area fraction of surfaces, where the bacterial medium is in contact with the solid surface.

Cited by 342 publications

References 40 publications

Reduced bacterial adhesion with parylene coating: Potential implications for Micra transcatheter pacemakers

Reduced bacterial adhesion with parylene coating: Potential implications for Micra transcatheter pacemakers

Hydrolysis of poly(l‐lactide)/ZnO nanocomposites with antimicrobial activity

Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces

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