“…Concerning the stability of coating, much efforts have been devoted to determine the immersion behavior of calcium phosphate coating in solutions with ionic composition similar to the inorganic fraction of blood plasma, such as phosphate buffered saline (PBS) solution [9], Hank's balanced salt solution (HBSS) [10,11] and Kokubo's simulated body fluid (SBF) [11,12]. These in vitro studies are important in a practical sense in that it could give some indication of the in vivo behavior of the coating.…”