Surface-Based Display of Volume-Averaged Cerebellar Imaging Data

Diedrichsen, Jörn; Zotow, Ewa

doi:10.1371/journal.pone.0133402

Cited by 239 publications

(242 citation statements)

References 47 publications

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“…( c ) Anatomical labels for the cerebellum. Labelling of the cerebellar nuclei and calculation of the flatmaps was performed using the SUIT toolbox .…”

Section: Resultsmentioning

confidence: 99%

Mild Thyrotoxicosis Leads to Brain Perfusion Changes: An Arterial Spin Labelling Study

Göbel

Heldmann

Sartorius

et al. 2017

J Neuroendocrinology

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Hypo- and hyperthyroidism have effects on brain structure and function, as well as cognitive processes, including memory. However, little is known about the influence of thyroid hormones on brain perfusion and the relationship of such perfusion changes with cognition. The present study aimed to demonstrate the effect of short-term experimental hyperthyroidism on brain perfusion in healthy volunteers and to assess whether perfusion changes, if present, are related to cognitive performance. It is known that an interaction exists between brain perfusion and cerebral oxygen consumption rate and it is considered that neural activation increases cerebral regional perfusion rate in brain areas associated with memory. Measuring cerebral blood flow may therefore represent a proxy for neural activity. Therefore, arterial spin labelling (ASL) measurements were conducted and later analysed to evaluate brain perfusion in 29 healthy men before and after ingesting thyroid hormones for 8 weeks. Psychological tests concerning memory were performed at the same time-points and the results were correlated with the imaging results. In the hyperthyroid condition, perfusion was increased in the posterior cerebellum in regions connected with cerebral networks associated with cognitive control and the visual cortex compared to the euthyroid condition. In addition, these perfusion changes were positively correlated with changes of performance in the German version of the Auditory Verbal Learning Task [AVLT, Verbaler Lern-und-Merkfähigkeits-Test (VLMT)]. Cerebellar perfusion and function therefore appears to be modulated by thyroid hormones, likely because the cerebellum hosts a high number of thyroid hormone receptors.

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“…( c ) Anatomical labels for the cerebellum. Labelling of the cerebellar nuclei and calculation of the flatmaps was performed using the SUIT toolbox .…”

Section: Resultsmentioning

confidence: 99%

Mild Thyrotoxicosis Leads to Brain Perfusion Changes: An Arterial Spin Labelling Study

Göbel

Heldmann

Sartorius

et al. 2017

J Neuroendocrinology

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“… Flattened z ‐statistic displays [Diedrichsen and Zotow, ] of average BIO > SCRAM cerebellar activity within (A) the full sample of TD adults and children and (B) the full sample of adults and children with ASD, with outlines indicating lobular structure overlaid in black. Below, regions displaying a significant psychophysiological interaction (PPI) between the BIO > SCRAM contrast and a seed region in right posterior superior temporal sulcus (RpSTS; panel E) for the full sample of TD adults and children (C) and the full sample of adults and children with ASD (D) are displayed as flattened z ‐statistic images.…”

Section: Methodsmentioning

confidence: 99%

Cerebellar contributions to biological motion perception in autism and typical development

Jack

Keifer

Pelphrey

2017

Human Brain Mapping

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Growing evidence suggests that posterior cerebellar lobe contributes to social perception in healthy adults. However, we know little about how this process varies across age and with development. Using cross-sectional fMRI data, we examined cerebellar response to biological (BIO) versus scrambled (SCRAM) motion within typically developing (TD) and autism spectrum disorder (ASD) samples (age 4–30 y), characterizing cerebellar response and BIO > SCRAM-selective effective connectivity, as well as associations with age and social ability. TD individuals recruited regions throughout cerebellar posterior lobe during BIO > SCRAM, especially bilateral lobule VI, and demonstrated connectivity with right posterior superior temporal sulcus (RpSTS) in left VI, Crus I/II, and VIIIb. ASD individuals showed BIO > SCRAM activity in left VI and left Crus I/II, and bilateral connectivity with RpSTS in Crus I/II and VIIIb/IX. No between-group differences emerged in well-matched subsamples. Among TD individuals, older age predicted greater BIO > SCRAM response in left VIIb and left VIIIa/b, but reduced connectivity between RpSTS and widespread regions of the right cerebellum. In ASD, older age predicted greater response in left Crus I and bilateral Crus II, but decreased effective connectivity with RpSTS in bilateral Crus I/II. In ASD, increased BIO > SCRAM signal in left VI/Crus I and right Crus II, VIIb, and dentate predicted lower social symptomaticity; increased effective connectivity with RpSTS in right Crus I/II and bilateral VI and I-V predicted greater symptomaticity. These data suggest that posterior cerebellum contributes to the neurodevelopment of social perception in both basic and clinical populations.

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“…The organization of these modules is reminiscent of immunohistological data on zebrin-positive and zebrin-negative stripes across the cerebellar cortex [16–18], a more nuanced picture that is best seen in flat map fMRI representations [19]. The positive and negative stripes for zebrin differ in their electrophysiological properties and innervation [17, 20, 21].…”

Section: Functional Neuroanatomy Of Cerebro-cerebellar Interplaymentioning

confidence: 99%

“…There appears to be a repeated mapping with, for example, prefrontal cortical areas (label 16 in C, D) represented in anterior and posterior lobes of the cerebellum (E). Adapted from [12], [178] and [19], with permissions.…”

Section: Figurementioning

confidence: 99%

The Cerebellum: Adaptive Prediction for Movement and Cognition

Sokolov

Miall

Ivry

2017

Trends in Cognitive Sciences

523

395

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Over the past 30 years, cumulative evidence has indicated that cerebellar function extends beyond sensorimotor control. This view has emerged from studies of neuroanatomy, neuroimaging, neuropsychology and brain stimulation, with the results implicating the cerebellum in domains as diverse as attention, language, executive function and social cognition. Although the literature provides sophisticated models of how the cerebellum helps refine movements, it remains unclear how the core mechanisms of these models can be applied when considering a broader conceptualization of cerebellar function. In light of recent multidisciplinary findings, we consider two key concepts that have been suggested as general computational principles of cerebellar function, prediction and error-based learning, examining how these might be relevant in the operation of cognitive cerebro-cerebellar loops.

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Surface-Based Display of Volume-Averaged Cerebellar Imaging Data

Cited by 239 publications

References 47 publications

Mild Thyrotoxicosis Leads to Brain Perfusion Changes: An Arterial Spin Labelling Study

Mild Thyrotoxicosis Leads to Brain Perfusion Changes: An Arterial Spin Labelling Study

Cerebellar contributions to biological motion perception in autism and typical development

The Cerebellum: Adaptive Prediction for Movement and Cognition

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