Surface-associated sialic acid is an immunological adjuvant

Dijk, Hans van; Rademaker, P.M.; Klerx, J.P.A.M.; Snippe, H.; Willers, J. M. N.

doi:10.1016/0165-2478(85)90117-8

Cited by 4 publications

(3 citation statements)

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“…Also, the life span of erythrocytes, platelets and serum glycoproteins is dependent upon their sialic acid content (26). In addition, sialic acids have been implicated in the masking of antigens (1), activation of alternative complement pathway (13) and of T and B lymphocytes (7) and may serve as an immunological adjuvant (30). Therefore, alterations due to the release of sialic acid should be expected in infections by neuraminidase producing organisms.…”

Section: Neuraminidasesmentioning

confidence: 99%

On the interaction of Trypanosoma cruzi neuraminidase and human lipoproteins

1991

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Section: Neuraminidasesmentioning

confidence: 99%

On the interaction of Trypanosoma cruzi neuraminidase and human lipoproteins

1991

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“…Sialic acid residues have been shown to promote the immunogenicity of sheep erythrocytes [6]. The immune re sponse to the non-sialated S. pneumoniae type-14 cap sular polysaccharide is lower than to the sialated cap sular polysaccharide of type-3 group-B streptococci [5].…”

Section: Discussionmentioning

confidence: 99%

“…The aim of the present study is to evaluate the effects of various agents mixed with or incorporated into haptenated liposomes on the primary antibody re sponse, the induction of IgG antibodies and immuno logical memory. Substances with varying sialic acid content and/or with a lipophilic character were used: the influence of sialic acid was studied, because it has been proved that sialic acid is an important regulator of the humoral immune response [5,6], Glycophorin A (GP-A), a sialic-acid-containing protein, was sim ply added to the liposome suspension. Bovine serum albumin (BSA) was used as a control to study the ef fect of mere protein addition on the immunogenicity of liposomes.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulating Properties of Substances to Be Used in Combination with Liposomes

Zigterman¹,

Jansze²,

Snippe³

et al. 1986

Int Arch Allergy Immunol

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Liposomes haptenated with tripeptide-enlarged dinitrophenyl (DNP) are known to act as thymus-independent antigens which induce a strong IgM response and only limited amounts of circulating IgG. When haptenated liposomes are used in vaccination studies, it is of practical importance to improve the immunogenicity of these complexes. Therefore, an evaluation was made of the potency of various substances to modulate the immune response in such a way that the total antibody production is increased, including a relative great increase of 2-merecaptoethanol (2-ME)-resistant antibodies and immunological memory is induced. The following substances were used: glycophorin A (GP-A), sialogangliosides (monosialo-, disialo- and trisialogan-glioside), 6–0-stearoyl-MDP (MDP-SA) and lipid A (lip A). Lip A incorporated into liposomes was the only substance inducing considerable increases of both total and 2-ME-resistant haemagglutination (HA) titre after immunization. Depending on the dose tested, the sialic-acid-containing protein GP-A had a small and varying influence on the serum antibody response. Sialogangliosides transiently decreased in a dose-dependent manner the total antibody titre in serum. In contrast to lip A, the lipophilic bacterial adjuvant MDP-SA did not influence HA titres significantly. The number of plaque-forming cells (PFC) in the spleen was enhanced considerably after both primary and secondary immunization with liposomes containing lip A. The other substances tested induced only minor differences of the number of PFC. To some extent, lip A induced immunological memory. In conclusion, it can be stated that of the agents tested, only lip A is a potent and consistent stimulator of the humoral immune response to liposomes haptenated with DNP groups. Sialogangliosides induced a transient decrease of the immune response to haptenated liposomes.

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L-fucosidase treatment blocks myelin phagocytosis by macrophages in vitro

Brück

Friede

1990

Journal of Neuroimmunology

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Surface-associated sialic acid is an immunological adjuvant

Cited by 4 publications

References 20 publications

On the interaction of Trypanosoma cruzi neuraminidase and human lipoproteins

On the interaction of Trypanosoma cruzi neuraminidase and human lipoproteins

Immunomodulating Properties of Substances to Be Used in Combination with Liposomes

L-fucosidase treatment blocks myelin phagocytosis by macrophages in vitro

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