Surface architectured black phosphorous nanoconstructs based smart and versatile platform for cancer theranostics

Pandey, Abhijeet; Nikam, Ajinkya Nitin; Padya, Bharath Singh; Kulkarni, Sanjay; Fernandes, Gasper; Shreya, Ajjappla Basavaraj; García, Mónica Cristina; Caro, Carlos; Páez-Muñoz, Jose María; Dhas, Namdev; García-Martín, María Luisa; Mehta, Tejal; Mutalik, Srinivas

doi:10.1016/j.ccr.2021.213826

Cited by 32 publications

(20 citation statements)

References 277 publications

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“…The area has been extensively reviewed, often including papers presenting the theranostic use of functionalized photothermal NP: fluorophores conjugated to NP may allow imaging, the T increase may promote the release of drugs, photoacoustic diagnostics may be associated to the photothermal therapy. [ 109 , 110 , 111 ] The interested reader is addressed to the many reviews that are focused on NP of a given material like Au,[ 35 , 112 , 113 , 114 ] C,[ 47 , 115 , 116 ] Si, [44] P, [117] Prussian blue,[ 40 , 118 ] or adopt a generalist approach. [ 59 , 119 , 120 ] The general scheme is to use NP presenting PTE, stabilize them with a coating that also imparts a stealth effect (in most cases poly(ethylene glycol), PEG), and often adding a targeting ligand on the NP surface, selective for the tumoral cells line to be treated.…”

Section: Biomedical Applications Of Pte Using Npsmentioning

confidence: 99%

Harvesting Light To Produce Heat: Photothermal Nanoparticles for Technological Applications and Biomedical Devices

Pallavicini

Chirico

Taglietti

2021

Chemistry A European J

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The photothermal properties of nanoparticles (NPs), that is, their ability to convert absorbed light into heat, have been studied since the end of the last century, mainly on gold NPs. In the new millennium, these studies have developed into a burst of research dedicated to the photothermal ablation of tumors. However, beside this strictly medical theme, research has also flourished in the connected areas of photothermal antibacterial surface coatings, gels and polymers, of photothermal surfaces for cell stimulation, as well as in purely technological areas that do not involve medical biotechnology. These include the direct conversion of solar light into heat, a more efficient sun-powered generation of steam and the use of inkjet-printed patterns of photothermal NPs for anticounterfeit printing based on temperature reading, to cite but a few. After an analysis of the photothermal effect (PTE) and its mechanism, this minireview briefly considers the antitumor-therapy theme and takes an in-depth look at all the other technological and biomedical applications of the PTE, paying particular attention to photothermal materials whose NPs have joined those based on Au.

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Section: Biomedical Applications Of Pte Using Npsmentioning

confidence: 99%

Harvesting Light To Produce Heat: Photothermal Nanoparticles for Technological Applications and Biomedical Devices

Pallavicini

Chirico

Taglietti

2021

Chemistry A European J

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“…This assembled structure can initiate the next reaction process, which induces numerous tracer indicators anchored onto the sensing interfaces, contributing to the superior specificity and recovery in spiked serum samples. In addition, black phosphorus can bind with antibodies and enhance electron transfer; thus, the black phosphorus electrochemical sensor based on magnetic covalent organic frameworks is developed to detect prostate-specific antigens, which can be widely applied in detecting biomarkers of cancer ( Pandey et al, 2021 ).…”

Section: Metal–organic Framework-based Compositesmentioning

confidence: 99%

Advanced Metal–Organic Frameworks-Based Catalysts in Electrochemical Sensors

et al. 2022

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Developing efficient catalysts is vital for the application of electrochemical sensors. Metal–organic frameworks (MOFs), with high porosity, large specific surface area, good conductivity, and biocompatibility, have been widely used in catalysis, adsorption, separation, and energy storage applications. In this invited review, the recent advances of a novel MOF-based catalysts in electrochemical sensors are summarized. Based on the structure–activity–performance relationship of MOF-based catalysts, their mechanism as electrochemical sensor, including metal cations, synthetic ligands, and structure, are introduced. Then, the MOF-based composites are successively divided into metal-based, carbon-based, and other MOF-based composites. Furthermore, their application in environmental monitoring, food safety control, and clinical diagnosis is discussed. The perspective and challenges for advanced MOF-based composites are proposed at the end of this contribution.

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“…Further, due to the enhanced permeation and retention (EPR) activity, they show preferential accumulation of antitumor drugs at the tumor site. Additionally, BP degradation is amplified under low pH conditions, improving the release of antitumor drugs in an acidic tumor microenvironment [ 33 ]. As a result, BPQDs are nearly nontoxic and have beneficial characteristics, including enhanced biocompatibility, desired degradability, and efficient therapeutic potential.…”

Section: Black Phosphorus Platforms In Breast Cancermentioning

confidence: 99%

“…When BP comes in contact with oxygen, either it gets oxidized into chemisorbed phosphorene, or there is a possibility for the introduction of oxygen interstitially, hampering the purity and anisotropic properties. Furthermore, due to the affinity of BP to water, it is easily degraded [ 33 ]. Surface modification is reported to be effective in overcoming these issues.…”

Section: Surface Modification Of Bpnssmentioning

confidence: 99%

“…PDA also has good photothermal effects and can enhance the stability of BPNS. Several other approaches are available for surface modification of BPNS, as described in detail elsewhere [ 33 , 72 , 76 ]. Here in this article, we have categorized the possibilities of surface modification into stimuli-responsive modifications and cell-organelle-targeted modifications.…”

Section: Surface Modification Of Bpnssmentioning

confidence: 99%

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2D Hetero-Nanoconstructs of Black Phosphorus for Breast Cancer Theragnosis: Technological Advancements

et al. 2022

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As per global cancer statistics of 2020, female breast cancer is the most commonly diagnosed cancer and also the foremost cause of cancer death in women. Traditional treatments include a number of negative effects, making it necessary to investigate novel smart drug delivery methods and identify new therapeutic approaches. Efforts for developing novel strategies for breast cancer therapy are being devised worldwide by various research groups. Currently, two-dimensional black phosphorus nanosheets (BPNSs) have attracted considerable attention and are best suited for theranostic nanomedicine. Particularly, their characteristics, including drug loading efficacy, biocompatibility, optical, thermal, electrical, and phototherapeutic characteristics, support their growing demand as a potential substitute for graphene-based nanomaterials in biomedical applications. In this review, we have explained different platforms of BP nanomaterials for breast cancer management, their structures, functionalization approaches, and general methods of synthesis. Various characteristics of BP nanomaterials that make them suitable for cancer therapy and diagnosis, such as large surface area, nontoxicity, solubility, biodegradability, and excellent near-infrared (NIR) absorption capability, are discussed in the later sections. Next, we summarize targeting approaches using various strategies for effective therapy with BP nanoplatforms. Then, we describe applications of BP nanomaterials for breast cancer treatment, which include drug delivery, codelivery of drugs, photodynamic therapy, photothermal therapy, combined therapy, gene therapy, immunotherapy, and multidrug resistance reversal strategy. Finally, the present challenges and future aspects of BP nanomaterials are discussed.

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Surface architectured black phosphorous nanoconstructs based smart and versatile platform for cancer theranostics

Cited by 32 publications

References 277 publications

Harvesting Light To Produce Heat: Photothermal Nanoparticles for Technological Applications and Biomedical Devices

Harvesting Light To Produce Heat: Photothermal Nanoparticles for Technological Applications and Biomedical Devices

Advanced Metal–Organic Frameworks-Based Catalysts in Electrochemical Sensors

2D Hetero-Nanoconstructs of Black Phosphorus for Breast Cancer Theragnosis: Technological Advancements

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