Abstract:that peptides in the I-state form pores, while peptides that remain in the S-state use the carpet model of membrane disruption. Here, OCD is used to investigate the orientation and threshold concentration of Piscidin 1 and Piscidin 3 (P3) in bacterial and mammalian-mimicking lipid systems and thereby determine the mechanism of action of P1 and P3 in these lipid systems. Both peptides are a 22-residue alpha-helical AMPs isolated from the mast cells of hybrid striped sea bass. P1 is both more antimicrobial and h… Show more
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