We explore the characterization of melamine formaldehyde resin (MF‐R) micron‐sized particles, immersed in argon, neon and argon–oxygen plasmas, using Raman spectroscopy. It is shown that plasma treatment of MF‐R results in modification of its chemical composition. Particularly, a decrease in the intensities of the Raman scattering bands, corresponding to both formaldehyde C―H and melamine C―N and N―H bonds, is observed. The band at 980–990 cm−1, associated with breathing vibrations of the triazine rings, undergoes the most significant changes, and the greatest modifications of the spectra are observed after exposure to Ar and Ar–O2 plasma, whilst for the MF‐R particles exposed to Ne plasma these modifications are less pronounced. Copyright © 2016 John Wiley & Sons, Ltd.