Surface anatomical profile of the cerebral cortex in obsessive–compulsive disorder: a study of cortical thickness, folding and surface area

Fan, Qing; Palaniyappan, Lena; Tan, Lian; Wang, J.; Wang, X.; Li, C.; Zhang, T.; Jiang, Kaida; Xiao, Zeping; Liddle, P. F.

doi:10.1017/s0033291712001845

Cited by 40 publications

(42 citation statements)

References 70 publications

(113 reference statements)

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“…Our results show a certain overlap with previous SBA studies in OCD samples: alterations in similar areas (i.e., parieto-occipital alterations, including the precuneus) partly overlap with the findings of Fan and colleagues, 20 and the same direction of alteration (i.e., decreases in volume and surface area) has been reported by Venkatasubramanian and colleagues. 19 However, whereas we found decreased grey matter surface area and volume in similar regions as Fan and colleagues, 20 their results showed mostly increased gyrification and thickness in those areas.…”

Section: Comparison With Surface-based Studiessupporting

confidence: 74%

“…Based on previous findings 19,20 we expected a significantly altered cortical morphology in these various grey matter measures in patients with OCD compared with controls. Additionally, we hypothesized that these structural alterations would be significantly associated with OCD psychopathology, which we investigated by correl ating the detected structural abnormalities with clinical scores (i.e., symptom severity).…”

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 68%

“…These alterations were partly associated with clinical characteristics (i.e., symptom severity, symptom type, disorder insight). Despite using the same method in an OCD sample with similar clinical characteristics (i.e., unmedicated patients), Fan and colleauges 20 found alterations that partly diverged from the findings of Venkatasubramanian and colleagues, 19 both regarding direction and location. Thus, the results by Fan and colleagues 20 revealed a significant increase in thickness in parietal areas and gyrification increases in a network containing the insula and frontal and occipital areas in patients with OCD that were positively associated with symptom severity.…”

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 86%

“…[16][17][18] To the best of our knowledge, only 2 studies have used the SBA approach in OCD samples to study gyrification, volume, surface area and thickness at the same time. 19,20 Venkatasubramanian and colleagues 19 applied SBA by using the automatic FreeSurfer software and provided first evidence of altered volume, surface area and thickness in a number of different regions comprising the ACC, OFC and occipital cortex in medication-naive patients with OCD. These alterations were partly associated with clinical characteristics (i.e., symptom severity, symptom type, disorder insight).…”

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 99%

“…The divergence in the direction of alteration may be partly driven by methodological differences in terms of clinical sample characteristics (i.e., previous studies investigated smaller samples and mainly unmedicated and comorbidityfree 20 or medication-naive patients 19 ). It is compelling that although other SBA studies 21,23,25,26,30,31 found grey matter thickness to be affected in patients with OCD, our results did not show such alterations in this measure, but we did find partly similar alterations in other measures.…”

Section: Comparison With Surface-based Studiesmentioning

confidence: 99%

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Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

Rus

Reeß

Wagner

et al. 2017

JPN

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IntroductionStudying the brain anatomic structure offers a promising approach to improve our understanding of neural functional alter ations often encountered in individuals with psychiatric disorders. In those with obsessive-compulsive disorder (OCD), a psychiatric disorder with a 2%-3% lifetime prevalence 1 that causes strong impairment of daily life, findings up to now show disruptions on a functional and a structural neural level, mainly in a network including cortico-striatothalamo-cortical (CSTC) areas. Overall, these findings are rather inconsistent and limited by confounding factors, such as differences in clinical characteristics of the study sample or varying methodological approaches.Meta-analytic reviews showed that cortical areas, mainly the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and parietofrontal regions, seem to be predominantly affected by grey matter volume deficits in patients with OCD, whereas the lenticular nuclei and thalamus were found to be characterized by increases in grey matter volume.2-4 A recent review article 5 confirmed these results and concluded that structural alterations in patients with OCD are widespread and occur most probably at a network level, with cortical tissue reductions and a tendency toward increases in grey matter volume of subcortical limbic areas. These subcortical tissue increases were also corroborated by a recent meta/mega-analysis of the ENIGMA OCD imaging consortium. 6 Additionally, this meta/mega-analysis showed that the neuroplasticity of specific areas depends on the age of the studied sample (i.e., smaller hippocampal but larger pallidum volumes were prominent in adults with OCD, whereas only larger thalamic volumes were specific for pediatric patients). Besides grey matter volume alterations in patients with OCD, significantly decreased grey matter thickness in partly overlapping areas (i.e., limbic, parietal and temporal areas) was also found in another recent mega-analysis. 7 It is Background: Mounting evidence indicates the presence of structural brain alterations in individuals with obsessive-compulsive disorder (OCD). Findings are, however, rather heterogeneous, which may be partly because of differences in methodological approaches or clinical sample characteristics. The aim of the present study was to analyze the whole brain cortical volume, surface area and thickness in a large sample of patients with OCD compared with age-and sex-matched healthy controls. Methods: We conducted whole brain surfacebased analyses of grey matter measures using the automated FreeSurfer software in patients with OCD and matched controls. Group analyses were performed and corrected for multiple testing using Monte Carlo simulations (p < 0.05). Altered brain regions and their average morphological values were associated to symptom severity and type (Yale-Brown Obsessive Compulsive Scale scores). Results:We included 75 patients and 75 controls in our analyses. Patients with OCD showed decreases in both volume and surface area compared with healthy ...

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Section: Comparison With Surface-based Studiessupporting

confidence: 74%

Section: J Psychiatry Neurosci 2017;42(6)mentioning

confidence: 68%