Surface analysis and bioreactions of Ti- and V-containing a-C : H

Abstract

Amorphous hydrogenated carbon films (a‐C : H) containing different amounts of Ti or V were produced by combined plasma‐activated chemical vapour deposition and d.c. magnetron sputtering. New bioactive materials resulted from the combination of the excellent tribological and biological properties of the a‐C : H matrix with the biological response to the incorporated metals. By adding Ti to the a‐C : H matrix, an enhanced differentiation of osteoblast‐ and reduced osteoclast‐like cell activity was achieved, leading to a coating that is valuable for bone implants: enhancing bone ingrowth through increased osteoblast activity and reducing bone resorption through osteoclast‐like cell inhibition. The a‐C : H/V films reduced lysosomal activity as well as neutral red uptake in bone marrow cell cultures, thus being an interesting coating for short‐term implants where reduced cell attachment is required. Prior to cell culture tests, the surfaces of the metal‐containing a‐C : H films were investigated by x‐ray photoelectron spectroscopy. The relation between chemical surface composition and cellular response is discussed. Copyright © 1999 John Wiley & Sons, Ltd.

Effect of plasma energy on enhancing biocompatibility and hemocompatibility of diamond-like carbon film with various titanium concentrations

“…Osteoclast is habited by the addition of Ti into the DLC and then bone marrow cells differentiate into bone resorbing cells. It is believed that Ti-DLC film is not only used as a coating and passive film, but also improved fixation and enhanced oseto/osseointegration [28,30]. As stated above, titanium doping into DLC film can improves biocompatibility obviously.…”

“…Furthermore, DLC film is a spurious base coating to be alloyed with various elements. The properties of DLC film can be promoted to include certain amounts of additional elements, such as F, N, O, Cu, V, Ti, Ta and their combinations [25][26][27][28], into the films and still maintain the microstructure without any phase transformation. Among them, titanium is a biocompatible material.…”

“…doi:10.1016/j.jallcom.2008.11.043 Table 1 Experimental conditions for the synthesis of Ti, DLC and Ti-DLC flm. Sample Ti DLC Ti-DLC-1 Ti-DLC-2 Ti-DLC-3 Ti- tents in DLC films [28]. The capability of adsorbing proteins will enhance cell attachment and subsequently induce cell proliferation and cell differentiation.…”

Plasmadeponierte Kohlenstoffbeschichtung auf urologischen Verweilkathetern

“…B. CF 4 , CH 4 , N 2 , V, Ag, Ti) mit unterschiedlichen Partialdrü-cken beeinflusst. Schichten mit auf den jeweiligen Einsatzzweck zugeschnittenen Volumen-und Oberflächeneigenschaften (Elastizität, Oberflächenspannung, innere Spannung, Härte, Reibung, biologisches Verhalten [15,16]) können durch einen geeigneten Prozessablauf auf praktisch jedes beliebige Material aufgebracht werden. Ausschlaggebend für den diamantähn-lichen Charakter der a-C:H-Schichten ist der Anteil an sp 3 -Bindungen im metastabilen amorphen Netzwerk aus sp 2 -und sp 3 -gebundenen Kohlenstoffatomen (Diamant =100% sp 3 , Graphit =100% sp 2 ).…”

Laser Processing of Advanced Bioceramics

“…Diamondlike carbon-calcium oxide composite films have been also been created that promote bone formation and growth. [90] Morphology and proliferation studies involving L929 mouse fibroblasts have shown that these films contribute to healthy cell morphology and increased cell proliferation. It is believed that calcium carbonate, which exhibits bioactive properties, is incorporated within these films.…”