Surface-active substrates for Raman and luminescence analysis

Vo‐Dinh, Tuan; Miller, Gregory R.; Bello, Job M.; Johnson, Randy W.; Moody, R.L.; Alak, Ala; Fletcher, Ww

doi:10.1016/0039-9140(89)80100-6

Cited by 40 publications

(15 citation statements)

References 16 publications

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“…Bello et al excited a silver-coated titanium dioxide nanoparticle substrate in the far-side illumination at a 90° scattering geometry and reported the observation of a SERS signal that was 11 times higher than in the direct illumination16. A similar behavior was observed by the same group again using silver-coated microspheres17. In the absence of a convincing mechanism or explanation via current theoretical accounts18, this additional enhancement appears to have been relatively neglected since then.…”

mentioning

confidence: 84%

“…Traditionally, the resulting SERS substrate is then excited from the “air” side in a backscattering geometry. Efforts to identify alternative measurement geometries have led to several reports that a larger SERS signal is obtained by excitation through the dielectric medium than by excitation through air1415161718. Jennings et al 14 reported the use of glass slides with vacuum deposited silver/indium island films and a 90° scattering geometry.…”

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confidence: 99%

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Additional Enhancement of Electric Field in Surface-Enhanced Raman Scattering due to Fresnel Mechanism

Jayawardhana

Rosa

Juodkazis

et al. 2013

Sci Rep

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Surface-enhanced Raman scattering (SERS) is attracting increasing interest for chemical sensing, surface science research and as an intriguing challenge in nanoscale plasmonic engineering. Several studies have shown that SERS intensities are increased when metal island film substrates are excited through a transparent base material, rather than directly through air. However, to our knowledge, the origin of this additional enhancement has never been satisfactorily explained. In this paper, finite difference time domain modeling is presented to show that the electric field intensity at the dielectric interface between metal particles is higher for “far-side” excitation than “near-side”. This is reasonably consistent with the observed enhancement for silver islands on SiO2. The modeling results are supported by a simple analytical model based on Fresnel reflection at the interface, which suggests that the additional SERS signal is caused by near-field enhancement of the electric field due to the phase shift at the dielectric interface.

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confidence: 84%

mentioning

confidence: 99%

Additional Enhancement of Electric Field in Surface-Enhanced Raman Scattering due to Fresnel Mechanism

Jayawardhana

Rosa

Juodkazis

et al. 2013

Sci Rep

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“…Assume the two foci are at z = ±d. Then the prolate spheroidal coordinates are given by ([29], p. 1284) (2) (3) (4) where 1 ≤ ξ < ∞, 0 ≤ ϑ ≤ π and 0 ≤ ϕ ≤ 2π (often the equivalent variable η = cos ϑ is used). Evidently, ξ plays the role of the "radial" coordinate, ϑ is the spheroidal colatitude angle and ϕ is the azimuthal angle.…”

Section: Spheroidal Coordinates and Boundary Conditionsmentioning

confidence: 99%

“…Our laboratory has been involved in the investigation and application of plasmonics nanosubstrates for SERS detection for over two decades. Since our first report on the practical analytical use of the SERS techniques for the trace analysis of a variety of chemicals including several homocyclic and heterocyclic polyaromatic compounds in 1984 [1], our laboratory has been involved in the development of SERS technologies for applications in chemical sensing, biological analysis and medical diagnostics [2]- [8]. Our substrates involve nanoparticles and seminanoshells consisting of a layer of nanoparticles coated by silver on one side (halfshells).…”

Section: Introductionmentioning

confidence: 99%

Plasmon Resonances of Nanoshells of Spheroidal Shape

Norton

Vo‐Dinh

2007

IEEE Trans. Nanotechnology

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“…Not only the development of efficient SERS-active solid substrates for trace organic analysis in biological and environmental applications [9][10][11][12], but also the development of SERS-active solid substrates for biomedical diagnostics has been the focus.…”

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confidence: 99%

Surface-enhanced Raman scattering for cancer diagnostics: detection of the BCL2 gene

Çulha

Stokes

Vo‐Dinh

2003

Expert Review of Molecular Diagnostics

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A method of detection for cancer genes, such as B-cell lymphoma 2 gene, has been developed using surface-enhanced Raman scattering-active substrates. This method uses Raman active dye-labeled DNA gene probes and metallic nanostructures as surface-enhanced Raman scattering-active platforms. A self-assembled monolayer system composed of mercapto hexane-labeled, single-strand DNA (SH-(CH2)6-ssDNA/ 6-mercapto-1-hexanol) is formed on a silver surface. The Raman-active dye-labeled gene is hybridized with its complementary probe, which is immobilized on the silver surface. The surface-enhanced Raman gene probes in this study can be used to detect DNA targets via hybridization to complementary DNA probes. The probes do not involve the use of radioactive labels and have great potential to provide both sensitivity and selectivity. The utility of this approach is investigated.

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Surface-active substrates for Raman and luminescence analysis

Cited by 40 publications

References 16 publications

Additional Enhancement of Electric Field in Surface-Enhanced Raman Scattering due to Fresnel Mechanism

Additional Enhancement of Electric Field in Surface-Enhanced Raman Scattering due to Fresnel Mechanism

Plasmon Resonances of Nanoshells of Spheroidal Shape

Surface-enhanced Raman scattering for cancer diagnostics: detection of the BCL2 gene

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