Surface‐Acoustic‐Wave (SAW) Induced Mixing Enhances the Detection of Viruses: Application to Measles Sensing in Whole Human Saliva with a SAW Lab‐On‐a‐Chip (Adv. Funct. Mater. 44/2022)

Agostini, M.; Lunardelli, Francesco; Gagliardi, Mariacristina; Miranda, Alessio; Lamanna, Leonardo; Luminare, Antonella Giuliana; Gambineri, Francesca; Lai, Michele; Pistello, Mauro; Cecchini, Marco

doi:10.1002/adfm.202270247

Cited by 7 publications

(11 citation statements)

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“…Polymeric flexible SAW device finds their natural outgrowth in the development of biosensor and Lab on a chip. [ 11,108 ] Portable, miniaturized, and compliant devices are required not only in healthcare monitoring but even in the food chain, to monitor contamination and food ripening, and even as support for environmental and agriculture monitoring. [ 109‐111 ] From this perspective, the development of polymeric SAW devices lags behind conventional SAW devices that have achieved remarkable advancements in recent years.…”

Section: Applicationsmentioning

confidence: 99%

“…[ 109‐111 ] From this perspective, the development of polymeric SAW devices lags behind conventional SAW devices that have achieved remarkable advancements in recent years. For example, conventional SAW devices have been able to detect various viruses such as Measles, [ 11 ] Influenza, [ 112 ] HIV, [ 113 ] and Ebola, [ 114 ] as well as cancer cells. [ 115,116 ] Furthermore, these devices can even detect biomolecules and protein markers [ 117,118 ] of some pathologies and toxins, [ 119,120 ] in some cases with sub‐nanomolar detection limits of 10^ 4 *10^ −12 M. [ 121 ] In recent years, SAW sensors have also been developed for the detection of DNA or even DNA polymorphisms.…”

Section: Applicationsmentioning

confidence: 99%

“…Surface acoustic wave (SAW) thin film devices rely on wave propagation in piezoelectric films, making them a crucial component in micro‐electro‐mechanical‐systems (MEMS) due to their low cost, low power consumption, and remote control capabilities. [ 6–12 ] The piezoelectric film is deposited directly onto the substrate, allowing for easy integration with other electronic systems. The development of thin substrates, including silicon, glass, and metal, paved the way for the creation of the first flexible SAW devices based on such substrates.…”

Section: Introduction and Fundamentals Of Sawmentioning

confidence: 99%

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Recent Progress in Polymeric Flexible Surface Acoustic Wave Devices: Materials, Processing, and Applications

Lamanna

2023

Adv Materials Technologies

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Recently, there has been a remarkable increase in interest in piezoelectric thin films, particularly zinc oxide (ZnO) and aluminum nitride (AlN), deposited on flexible polymeric substrates. This is due to the rapid expansion of fields such as robotics, wearable devices, and the Internet of Things (IoT). These thin‐film layered structures have a wide range of applications, such as energy harvesting, sensing and biosensing, microfluidic sorting, pumping and mixing, and telecommunications. One of the most promising platforms is piezoelectric acoustic‐based thin‐film devices on inexpensive, recyclable, or disposable polymeric substrates. Their reliability, reproducibility, conformability, small size, and wireless control capabilities make them a leading candidate for the development of new wireless, fully automated, and digitized microsystems for IoT and wearable devices. This review examines recent advancements in the engineering of ZnO and AlN thin films on polymeric, flexible, and conformable surface acoustic wave (SAW) devices. Topics covered include the materials used, piezoelectric film deposition, device fabrication, and the latest applications of this technology as sensors and actuators.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Introduction and Fundamentals Of Sawmentioning

confidence: 99%

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Recent Progress in Polymeric Flexible Surface Acoustic Wave Devices: Materials, Processing, and Applications

Lamanna

2023

Adv Materials Technologies

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“…Surface acoustic wave (SAW) devices are widely used in a variety of applications including wireless telecommunications, [ 1,2 ] sensing, [ 3–5 ] and microfluidics. [ 6,7 ] Over the past few years, their scope of use has significantly expanded and SAWs are now considered as promising systems for condensed matter physics.…”

Section: Introductionmentioning

confidence: 99%

On‐Chip Tightly Confined Guiding and Splitting of Surface Acoustic Waves Using Line Defects in Phononic Crystals

Gao

Benchabane

Bermak

et al. 2023

Adv Funct Materials

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Phononic crystals (PnCs) exhibit acoustic properties that are not usually found in natural materials, which leads to the possibility of new devices for the complex manipulation of acoustic waves. In this article, a micron-scale phononic waveguide constructed by line defects in PnCs to achieve on-chip, tightly confined guiding, bending, and splitting of surface acoustic waves (SAWs) is reported. The PnC is made of a square lattice of periodic nickel pillars on a piezoelectric substrate. The PnC lattice constant, pillar diameter, and pillar height are set to 10, 7.5, and 3.2 µm, respectively, leading to a complete bandgap centered at 195 MHz. Interdigitated transducers are monolithically integrated on the same substrate for SAW excitation. The guiding, bending, and splitting of SAWs in the phononic waveguide are experimentally observed through measurement of the out-of-plane displacement fields using a scanning optical interferometer. The combination of destructive interference due to the Bragg bandgap and the interaction of the propagating wave with the pillars around the channel results in a tight confinement of the displacement field. The proposed phononic waveguides demonstrate the feasibility of precise local manipulation of SAW that is essential for emerging frontier applications, notably for phonon-based classical and quantum information processing.

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“…The technological healthcare revolution is deemed to transform our lives. [ 1,2 ] The use of wearable, [ 3,4 ] implantable, [ 5 ] and ingestible devices [ 6 ] will deliver continuous monitoring of physiological metrics, personalized therapies, and rapid sharing of data between patients and caregivers, offering new and unprecedented opportunities for diagnosis and treatments. In this context, ingestible electronic (IE) devices represent an emerging key tool supporting medicine.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Drug Release via Intra Body Communication with an Edible Pill

Lamanna

Cataldi

Friuli

et al. 2022

Adv Materials Technologies

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Oral drug administration provides a convenient and patient‐compliant way for drug delivery, especially for chronic diseases and prolonged pharmacological treatments. However, due to the repetitiveness of such therapeutic approach, the patients are led to neglect/forget the therapy affecting the healthcare delivery. Indeed, the non‐adherence to pharmacological prescriptions and the unknown amount of real‐time drug release result in a non‐compliant therapeutic drug level over the protracted therapies. The proposed technology will enable the monitoring of both pharmacological adherence and real‐time drug release. The approach exploits a passive intrabody communication (IBC) activation in order to enable an edible pill, realized starting from food additives and food‐grade materials, to monitor pharmacological adherence. Following activation, the signal is modulated by IBC coupling switching triggered by pill degradation in a gastrointestinal tract, resulting in a monitored drug release. The proof‐of‐concept is designed for a targeted release and monitoring of Metformin in the intestine. The system shows an in vitro limit of cumulative drug release detection of 18 µg mL−1 and a limit of real‐time drug release detection of 2 µg mL−1 min−1. This platform represents the first solution to monitor passive drug release in real‐time, from intake to complete absorption, enabling unique and long‐sought healthcare therapy and treatment opportunity.

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Surface‐Acoustic‐Wave (SAW) Induced Mixing Enhances the Detection of Viruses: Application to Measles Sensing in Whole Human Saliva with a SAW Lab‐On‐a‐Chip (Adv. Funct. Mater. 44/2022)

Cited by 7 publications

References 0 publications

Recent Progress in Polymeric Flexible Surface Acoustic Wave Devices: Materials, Processing, and Applications

Recent Progress in Polymeric Flexible Surface Acoustic Wave Devices: Materials, Processing, and Applications

On‐Chip Tightly Confined Guiding and Splitting of Surface Acoustic Waves Using Line Defects in Phononic Crystals

Monitoring of Drug Release via Intra Body Communication with an Edible Pill

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