Surface acoustic wave–liquid drop interactions

Newton, MI; Banerjee, M. K.; Starke, Thomas; Rowan, S. M.; McHale, Glen

doi:10.1016/s0924-4247(98)00356-2

Cited by 13 publications

(4 citation statements)

References 7 publications

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“…The longitudinal waves propagate into the fluid with the Rayleigh angle R [7], as shown in figure 1. The generated body force can create significant acoustic streaming in liquid and facilitate liquid mixing, stirring, vibrating, pumping, ejection and atomization [8]. SAW-based systems such as liquid pumps and mixers [9,10], droplet manipulators [11], droplet ejectors and atomizers [12,13], and fluidic dispensing arrays [14] have been reported.…”

Section: Introductionmentioning

confidence: 99%

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO₃substrate

Alghane

Chen

et al. 2010

J. Micromech. Microeng.

113

101

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This work uses a finite volume method to investigate three-dimensional acoustic streaming patterns produced by surface acoustic wave (SAW) propagation within microdroplets. A SAW microfluidic interaction has been modelled using a body force acting on elements of the fluid volume within the interaction area between the SAW and fluid. This enables the flow motion to be obtained by solving the laminar incompressible Navier–Stokes equations driven by an effective body force. The velocity of polystyrene particles within droplets during acoustic streaming has been measured and then used to calibrate the amplitudes of the SAW at different RF powers. The numerical prediction of streaming velocities was compared with the experimental results as a function of RF power and a good agreement was observed. This confirmed that the numerical model provides a basic understanding of the nature of 3D SAW/liquid droplet interaction, including SAW mixing and the concentration of particles suspended in water droplets.

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Section: Introductionmentioning

confidence: 99%

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO₃substrate

Alghane

Chen

et al. 2010

J. Micromech. Microeng.

113

101

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“…The Haemoprocessor uses a travelling SAW (TSAW) [ 27 , 28 , 29 ] generated by applying a high frequency AC voltage to one of the eight IDTs patterned on the LiNbO 3 substrate at their designated frequencies. When this ‘out-of-plane’ surface wave traveling on the substrate reached the fluid volume bounded by the doughnut shaped open track, it began transferring mechanical energy to the liquid media and generated a rapidly decaying pressure wave propagating within the fluid at the Rayleigh angle in the out of plane direction [ 30 , 31 , 32 ]. The attenuation of the pressure field in the bulk of the fluid, as well as along the fluid-substrate interface, resulted in a spatial variation in the body forces acting in the fluid and generated an acoustic streaming field [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Haemoprocessor: A Portable Platform Using Rapid Acoustically Driven Plasma Separation Validated by Infrared Spectroscopy for Point-of-Care Diagnostics

et al. 2022

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The identification of biomarkers from blood plasma is at the heart of many diagnostic tests. These tests often need to be conducted frequently and quickly, but the logistics of sample collection and processing not only delays the test result, but also puts a strain on the healthcare system due to the sheer volume of tests that need to be performed. The advent of microfluidics has made the processing of samples quick and reliable, with little or no skill required on the user’s part. However, while several microfluidic devices have been demonstrated for plasma separation, none of them have validated the chemical integrity of the sample post-process. Here, we present Haemoprocessor: a portable, robust, open-fluidic system that utilizes Travelling Surface Acoustic Waves (TSAW) with the expression of overtones to separate plasma from 20× diluted human blood within a span of 2 min to achieve 98% RBC removal. The plasma and red blood cell separation quality/integrity was validated through Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy and multivariate analyses to ascertain device performance and reproducibility when compared to centrifugation (the prevailing gold-standard for plasma separation). Principal Component Analysis (PCA) showed a remarkable separation of 92.21% between RBCs and plasma components obtained through both centrifugation and Haemoprocessor methods. Moreover, a close association between plasma isolates acquired by both approaches in PCA validated the potential of the proposed system as an eminent cell enrichment and plasma separation platform. Thus, compared to contemporary acoustic devices, this system combines the ease of operation, low sample requirement of an open system, the versatility of a SAW device using harmonics, and portability.

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“…6 The SAW device played a vital role in the generation of acoustic mixing, which, in turn, facilitated pumping, 7,8 stirring, 9, 10 concentration of particles, 11 vibrating, 12,25 and atomization. 13,14 Acoustic mixing inside a droplet due to a SAW interaction is a three-dimensional phenomenon, but to reduce the computational time and complications in geometry modelling, a past two-dimensional analysis was performed to study this phenomenon. 15 For the same reason, there are very few re- ported cases which extend up to the 3-D model design of efficient SAW devices for micro-fluidics and lab-on-chip devices.…”

Section: Introductionmentioning

confidence: 99%

Numerical Investigation of Surface Acoustic Wave (SAW) Interacting with a Droplet for Point-of-Care Devices

Shah¹,

Uddin²,

Mubashar³

et al. 2019

The International Journal of Acoustics and Vibration

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A three-dimensional numerical simulation of the interaction of a surface acoustic wave (SAW) with a droplet of water is carried out. The mixing produced inside the droplet due to the incident with the SAW and the droplet is investigated by undertaking a parametric study, with parameters such as frequency, drop size, and the lateral position of the droplet on the surface of the substrate. The linear relationship between the input voltage and the mixing velocity inside the droplet is obtained with variation of the input voltage of the inter-digital transducer (IDT) of the SAW device within a 10--40 V range. With the variation in frequency, the maximum mixing velocity is observed at 20 MHz and it appears to be independent of the size of the droplet. Varying the substrate material with lead zirconate titanate and lithium niobate produces better mixing. Lithium niobate is preferred due to its availability and cost-effectiveness. A drop of 600 um diameter produces better mixing. The different velocities inside the drop and the SAW device are obtained by changing the droplet position in the lateral direction (asymmetrical position) from the centre of the substrate. Cut planes parallel and perpendicular to the SAW at the core of a half-spherical droplet are observed to visualise the mixing effects inside the droplet during the interaction. To achieve the best mixing criteria, the droplet is moved in a lateral direction. An efficient parametric design for the mixing phenomena in micro-fluidic devices is presented for point-of-care devices.

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Surface acoustic wave–liquid drop interactions

Cited by 13 publications

References 7 publications

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO₃substrate

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO₃substrate

Haemoprocessor: A Portable Platform Using Rapid Acoustically Driven Plasma Separation Validated by Infrared Spectroscopy for Point-of-Care Diagnostics

Numerical Investigation of Surface Acoustic Wave (SAW) Interacting with a Droplet for Point-of-Care Devices

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Surface acoustic wave–liquid drop interactions

Cited by 13 publications

References 7 publications

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO3substrate

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO3substrate

Haemoprocessor: A Portable Platform Using Rapid Acoustically Driven Plasma Separation Validated by Infrared Spectroscopy for Point-of-Care Diagnostics

Numerical Investigation of Surface Acoustic Wave (SAW) Interacting with a Droplet for Point-of-Care Devices

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Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO₃substrate

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO₃substrate