Suramin inhibiert Todesrezeptor-vermittelte Apoptose und fulminantes Leberversagen in Mäusen

Eichhorst, S.T.; Krueger, Andreas; Müerköster, Susanne Sebens; Fas, SC; Golks, Alexander; Gruetzner, Uwe; Schubert, L; Opelz, Christine; Bilzer, Manfred; Gerbes, AL; Krammer, PH

doi:10.1055/s-2004-831781

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“…In this pathway of apoptosis, TNF-α or other death receptor ligands can activate death receptors on the proximal tubule cell surface leading to caspase 8 cleavage and activation followed by the cleavage and activation of downstream effector caspases such as caspase 3, leading to apoptosis (52). Suramin has been shown to inhibit TNF-α from binding with the death receptor (33). Interestingly our results show that pre-treatment with suramin prior to cisplatin treatment significantly decreases both caspase 8 and caspase 3 cleavage, suggesting that suramin is preventing cisplatin-induced death receptor-mediated apoptosis in the kidney, while suramin pretreatment also decreased the renal expression of TNF-α in mice treated with cisplatin.…”

Section: Figure 1 Pretreatment With High Dose Suramin Improves Markementioning

confidence: 99%

Suramin protects from cisplatin-induced acute kidney injury.

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In rodent models, suramin improves recovery following acute kidney injury (AKI). We hypothesized that suramin would be useful in protection against cisplatin-induced AKI.This hypothesis was tested by pre-treating C57BL/6j mice with suramin prior to cisplatin.Our data indicates that suramin protects the kidney from injury by decreasing cisplatininduced decreases in kidney function. Renal histology indicated that suramin significantly protected from cisplatin-induced AKI. Data indicate that suramin pretreatment attenuated mRNA expression of pro-inflammatory cytokines and chemokines following cisplatin treatment, while also decreasing markers of cell stress and cell death. We utilized the same experimental design with 10-month old FVB mice expressing mutant Kras driven lung adenocarcinomas. Assessment of lung histology and kidney function indicated that suramin protected mice from cisplatin-induced AKI and did not inhibit cisplatin's anti-tumor efficacy. These results suggest that suramin shows great potential as a renoprotective agent for the treatment/ prevention of cisplatininduced AKI.

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Section: Figure 1 Pretreatment With High Dose Suramin Improves Markementioning

confidence: 99%

Suramin protects from cisplatin-induced acute kidney injury.

Dupre¹

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Suramin inhibiert Todesrezeptor-vermittelte Apoptose und fulminantes Leberversagen in Mäusen

Cited by 1 publication

References 0 publications

Suramin protects from cisplatin-induced acute kidney injury.

Suramin protects from cisplatin-induced acute kidney injury.

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