Sur la synthèse de l'acide inosito‐hexaphosphorique

Posternak, Swigel

doi:10.1002/hlca.19210040112

Cited by 28 publications

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“…Both the crystalline form (C), originally obtained by Posternak (1921), and (A), are reportedly stable hydrates, while (B) is efflorescent. Crystals used in the present study, obtained from an aqueous solution of sodium phytate, lost water of hydration and became highly disordered within a few hours after exposure to air; thus they were necessarily sealed in capillaries during X-ray measurements.…”

Section: Resultsmentioning

confidence: 92%

Hemoglobin cofactors. I. The crystal structure of myoinositol hexaphosphate dodecasodium salt octatriacontahydrate

Blank¹,

Pletcher²,

Sax³

1975

Acta Crystallogr Sect B

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The crystal structure of myoinositol hexaphosphate dodecasodium salt has been determined for the octatriacontahydrate form which crystallizes in space group Ce, a=23.091 (13), b--12-203 (10), c= 22"894 (14) A, fl= 108"30 (1) °, and Z=4. As the crystalline hydrated sodium salt, myoinositol hexaphosphate has the sterically unfavorable (5-axial/I-equatorial) ring conformation. This conformer is stabilized by the mutual repulsion of 1,2-vicinal ionized phosphates, sodium ion bridging of both 1,3-syn and 1,2-vicinal phosphates and hydrogen-bonded water molecules. A degree of structural stability is gained from the uncommon mode of sodium coordination to ester oxygens. Three types of polyhedral arrangements are observed for the oxygen atoms coordinated to sodium. These have triangular faces, and examples of face-, edge-, and corner-sharing are found. The phytate molecule assumes an asymmetric conformation with a pseudo-center of symmetry. An empirical stereochemical analysis of the 1,3-syn steric effects is qualitatively consistent with observed conformational features. The stereochemical properties of phytate are discussed with regard to its biological roles in enzymatic dephosphorylation and as a structural analogue of polyphosphoinositides.

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Section: Resultsmentioning

confidence: 92%

Hemoglobin cofactors. I. The crystal structure of myoinositol hexaphosphate dodecasodium salt octatriacontahydrate

Blank¹,

Pletcher²,

Sax³

1975

Acta Crystallogr Sect B

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“…Winterstein [4], Schulze and Winterstein [5] and Posternak [6] showed that hydrolysing phytin by hydrochloric acid liberated phosphoric acid and inositol. To explain the high phosphorous, calcium and magnesium contents of phytin, paired phosphoric acids were discussed as possible structures [7,8]. Other molecular structures, however, were also under controversial debate for many years [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…To explain the high phosphorous, calcium and magnesium contents of phytin, paired phosphoric acids were discussed as possible structures [7,8]. Other molecular structures, however, were also under controversial debate for many years [8,9]. In 1914, Anderson [10] presented the molecular structure of myo-inositol-1,2,3,4,5,6-hexakis dihydrogen phosphate, also called phytic acid ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysis

Schlemmer¹,

Frølich

Prieto

et al. 2009

Molecular Nutrition Food Res

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604

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The article gives an overview of phytic acid in food and of its significance for human nutrition. It summarises phytate sources in foods and discusses problems of phytic acid/phytate contents of food tables. Data on phytic acid intake are evaluated and daily phytic acid intake depending on food habits is assessed. Degradation of phytate during gastro-intestinal passage is summarised, the mechanism of phytate interacting with minerals and trace elements in the gastro-intestinal chyme described and the pathway of inositol phosphate hydrolysis in the gut presented. The present knowledge of phytate absorption is summarised and discussed. Effects of phytate on mineral and trace element bioavailability are reported and phytate degradation during processing and storage is described. Beneficial activities of dietary phytate such as its effects on calcification and kidney stone formation and on lowering blood glucose and lipids are reported. The antioxidative property of phytic acid and its potentional anticancerogenic activities are briefly surveyed. Development of the analysis of phytic acid and other inositol phosphates is described, problems of inositol phosphate determination and detection discussed and the need for standardisation of phytic acid analysis in foods argued.

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Ploetz¹

1943

Angewandte Chemie

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Sur la synthèse de l'acide inosito‐hexaphosphorique

Cited by 28 publications

References 0 publications

Hemoglobin cofactors. I. The crystal structure of myoinositol hexaphosphate dodecasodium salt octatriacontahydrate

Hemoglobin cofactors. I. The crystal structure of myoinositol hexaphosphate dodecasodium salt octatriacontahydrate

Phytate in foods and significance for humans: Food sources, intake, processing, bioavailability, protective role and analysis

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