Sur la constitution de la Dioscorine

Abstract

II y a quelque temps j'ai publik dans les Annales du Jardin Botanique de Buitenzorg 1) lee rhsultats prkliminaires de recherches sur la Dioscorine, l'alcalo'l'de toxique de la D i o s c CI r e a h i r 8 u t a B 1. Depuis, j'ai ponrsuivi ces recherches, et je me propose de donner ici un expose detail16 des experiences qni m'ont permis d'dlucider la constitution de cette substance.Les tubercules de la D i o s c o r e a h i r s n t a Bl.,connusA Java sous le nom de ,gadoeng", sont assez frkquemment employks comme substance alimentaire par lea indigenes, qui leur font prhalablement subir nn traitement special destine, A en extraire le poison et A les rendre par 1B inoffensifs. Dans ce but, ils coupent les tnbercules en tranche8 minces,. les recouvrent parfois de cendrc et les mettent pendant 24 henres ou plus dans la riviere.

Andropanolide and Isoandrographolide, Minor Diterpenoids from Andrographis paniculata: Structure and X-ray Crystallographic Analysis

“…28 A compound with similar structure but with unknown C-14 stereochemistry has been reported earlier from A. paniculata 10 and as a metabolite of andrographolide in rats. 28 The spectroscopic data reported are in good agreement with those observed by us for andropanolide (1), which settles the structure of these products. The methyl group at C-10 (supposed to be R as in case of andrographolide) showed a strong NOE interaction with H-12; the latter must therefore be R-oriented.…”

“…IR spectra were recorded as KBr pellets using a JASCO 7300 FTIR spectrometer. 1 H and 13 C NMR spectra were recorded using a Bruker DRX spectrometer (500 MHz). The mass spectra were recorded on a Q-TOF-Micromass spectrometer.…”

“…Andrographis paniculata Nees (Acanthaceae) is a small herb found throughout southeast Asia and India. Extracts of this plant and its constituents are reported to exhibit a wide spectrum of biological activities including antibacterial, antiinflammatory, antimalarial, , antithrombotic, hepatoprotective, and immunostimulant properties.…”

“…10 Previous investigations on the chemical composition of A. paniculata showed that it is a rich source of labdane diterpenoids 6,[10][11][12][13][14][15][16][17][18] and 2′-oxygenated flavonoids. 16,[18][19][20][21][22][23] In the present study, we report the isolation of andropanolide (1), a new labdane diterpenoid, along with seven known diterpenoids, andrographolide, 6,[10][11][12][13][14][15][16][17][18] andrograpanin, 10,14,18 isoandrographolide (2), 24,25 14-deoxy-11,12-didehydroandrographolide, 10,13,17,18 14deoxyandrographolide, 10,[12][13][14]18 isoandrographolide (2), 24,25 neoandrographolide, 10,12,14,…”

Synthesis and discovery of andrographolide derivatives as non-steroidal farnesoid X receptor (FXR) antagonists

“…31 Andrographolide (1, Fig. 1), 32,33 a diterpene ester from Andrographis panniculata (Burm.f.) Nees, was identied as a weak FXR antagonist (IC 50 ¼ 9.7 mM, Fig.…”