Sur l'histophysiologie corrélative de la glande pinéale et des glandes parathyroides

Miline, R.; Krstić, Radivoj V.

doi:10.1007/bf00406294

Cited by 12 publications

(4 citation statements)

References 4 publications

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“…With respect to the parathyroid glands, it had been found that pinealectomy is followed by hypertrophy and hyperplasia of parathyroid cells, whereas administration of pineal substances leads to an atrophy (KrstiC, 1966(KrstiC, , 1967(KrstiC, , 1968Miline and KrstiC, 1966), pointing to an inhibiting effect of the pineal gland on the parathyroids. By contrast, Kiss et al (1969) observed an atrophy of the parathyroid and a decrease of 3H-methionine incorporation which suggests that the pineal may stimulate the parathyroid gland.…”

Section: Discussionmentioning

confidence: 99%

Number and size of rat thyroid C cells: No effect of pinealectomy

1985

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A method for the estimation of the size and total number of calcitonin-containing cells (C cells) in the rat thyroid gland has been devised. The total area, the number of C cells per unit area, and the areal fraction of C cells were determined for the C cell region using step serial sections. From these data it was estimated that from 0.3 X 10(6) to 1.0 X 10(6) C cells were evenly divided between the two thyroid lobes. Approximately 150 micron3 of cytoplasm were associated with each of these cells. In comparison with sham-operated rats, pinealectomy had little effect on the number of C cells. In an experiment terminated in the summer, there was a statistically insignificant decrease 6 weeks postsurgery; no effect was seen at 12 weeks. On the other hand, a slight increase in the number of C cells was seen in January, 12 weeks postsurgery. The volume of cytoplasm per cell was not altered by pinealectomy.

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Section: Discussionmentioning

confidence: 99%

Number and size of rat thyroid C cells: No effect of pinealectomy

1985

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“…Pinealectomy leads to hypertrophy and hyperplasia of parathyroid cells, accompanied by slightly elevated blood calcium levels [8], while administration of pineal substances is followed by atrophy of parathyroid cells [15]. Thus, it would appear that the pineal may inhibit parathyroid func tion.…”

Section: Discussionmentioning

confidence: 99%

Electrical Responses of Pineal Cells to Thyroid Hormones and Parathormone

Semm¹,

Demaine²,

Vollrath³

1981

Neuroendocrinology

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The effects of microelectrophoretic application of thyroxin, thyrocalcitonin and parathormone on pineal cells of urethane anesthetized guinea pigs were evaluated. A total of 162 cells were tested with thyroxin, 122 of these units also being subjected to the microelectrophoresis of the indolamine melatonin. 68 cells were excited by the administration of thyroxin, 63 were inhibited while the remaining cells did not respond. 79% of the cells tested with both thyroxin and melatonin responded in a similar way to the two substances. The responses to thyroxin varied significantly depending on whether the cells were tested during the day or at night. 104 pineal cells were tested with thyrocalcitonin, 20 U exhibiting an increased firing frequency, 58 showing an inhibitory response and the remaining 26 being unresponsive. Parathormone was applied to 64 pineal cells. Of the 43 cells responding to the hormone, 29 were excited and 14 showed decreased activity. In general, these results suggest that pineal cells may be subject to feedback control by the hormones of the thyroid and parathyroid glands.

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“…The pineal gland could influence two important components of the calcium-regulating system in the bodythat is, parathyroid and C cells-with an action that is at times stimulating and at times inhibitory 9,10 . Animal data indicate that pineal melatonin is involved in the regulation of calcium and phosphorus metabolism by stimulating the activity of the parathyroid glands and inhibiting calcitonin release and prostaglandin synthesis [21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

“…Although some studies have shown an increase in the number of these cells [9][10][11] , of their cytoplasm/nucleus ratio and of the number of secretary granules 12 after pinealectomy (PX), McMillan et al 13 detected no significant differences in any of these parameters following PX.…”

Section: Introductionmentioning

confidence: 99%

C cells in the thyroid of pinealectomized rats

Lima

Freitas

et al. 2003

Rev. Hosp. Clin.

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PURPOSE: To study quantitatively C cells in the thyroids of non-isogenic rats to determine the possible effects of pinealectomy on the number of these cells, and consequently on the synthesis and secretion of calcitonin. METHODS: Twenty male rats of an outbred strain (200-300 g) were used in the present study. One group of 10 animals was pinealectomized 50 days prior to sacrifice. Thyroid tissue was stained for calcitonin (Dako Corporation) at a 1:1500 dilution. The number of C cells observed was expressed as number of cells/cm². Data were analyzed statistically by Mann-Whitney test. RESULTS: The number of C cells in pinealectomized and normal animals ranged from 489 to 2084 per cm² and 227 to 1584 per cm², respectively, a difference that was statistically significant (P <0.05). CONCLUSIONS: These results showed consistent differences in the number of C cells after pinealectomy when compared to controls. We believe that pinealectomy increases the number of C cells in the rat thyroid.

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Sur l'histophysiologie corrélative de la glande pinéale et des glandes parathyroides

Cited by 12 publications

References 4 publications

Number and size of rat thyroid C cells: No effect of pinealectomy

Number and size of rat thyroid C cells: No effect of pinealectomy

Electrical Responses of Pineal Cells to Thyroid Hormones and Parathormone

C cells in the thyroid of pinealectomized rats

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