Suprofen-Related Nephrotoxicity

Abstract

We describe a unique clinical syndrome of flank pain and acute renal failure that is associated with suprofen, a nonsteroidal anti-inflammatory drug that has recently been made available in the United States. In the initial 6 months of the drug's distribution in this country, at least 16 patients developed this syndrome. All 16 had acute flank pain and 13 developed mild reversible renal failure within 12 hours of ingestion of one to three suprofen capsules. This syndrome is unlike other nephrotoxic syndromes related to nonsteroidal anti-inflammatory drugs. The mechanism is not known.

COtab: Expedient and Safe Setup for Pd-Catalyzed Carbonylation Chemistry

“…10−12 as demonstrated in Scheme 4. 25 Furthermore, by utilizing conditions favoring the carbonylative Suzuki−Miyaura reaction, 26 precursors for suprofen (NSAID) 27 and benzodiazepines 28 (compounds 13 and 14) could be obtained, as well as the blood cholesterol lowering drug fenofibrate (15). 29 Finally, three different types of carbonylative α-arylation reactions were successfully demonstrated, resulting in the formation of 1,3-diketones 16 and 17, 30 the pyrazinecontaining ketone 18, 31 and the 1,3-ketoamide 19.…”

Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac

“…A number of acidic NSAIDs (including tolmetin and zomepirac) have elicited potentially fatal hypersensitivity reactions (including anaphylaxis, bronchospasm and hepatotoxicity) [7][8][9][10]. We have hypothesized that the allergic-like reactions and the organ toxicities may occur via an immune-based mechanism whereby the acyl glucuronide metabolite of acidic NSAIDs acts as a hapten upon covalent binding to a protein.…”