Supravital Study of Guinea Pig Cochlea Referring Especially to Kanamycin Labyrinthotoxy

Fifty-four healthy guinea pigs were studied histologically for evaluation of Tobramycin sulfate ototoxicity. They were treated with 50, 100, 150 and 200 mg/kg/day under different schedules. Loss of hair cells occurred when dosage of 1,200 mg/kg was reached. Animals receiving 700 mg/kg were without damage to the inner ear. Outer hair cell loss occurred first in the basal turn, spreading upward. Inner hair cell loss began in the apical turn, progressing downward. When a total dose of 1,400 mg/kg was reached by (two) different schedules the higher daily dose produced about twice the hair cell loss; therefore, the ototoxic effect depends on the total dose but even more on the increased blood concentration.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Supravital Study of Guinea Pig Cochlea Referring Especially to Kanamycin Labyrinthotoxy

Cited by 4 publications

References 10 publications

Estudio ultraestructural de la porción lateral del órgano sensorial auditivo mediante un método sin descalcificación

Estudio ultraestructural de la porción lateral del órgano sensorial auditivo mediante un método sin descalcificación

Ultra-Structural Study of the Lateral Portion of the Auditory Sensorial Organ Using a Decalcification-Free Method

Ototoxicity of tobramycin sulfate

Contact Info

Product

Resources

About