“…On rare occasions these advantages can be offset by several adverse effects, some of which are serious and potentially fatal, such as air embolism, postural hypotension and intracerebral haemorrhage remote from the operative site s, 6,29 A further complication of the sitting position has been identified in recent years, namely the large intracranial accumulation of air under pressure, i.e., tension pneumocephalus, which results in progressive obtundation, with or without lateralizing signs 3, 7, 9, 10, 12--14, 19, 21 In practice, however, the incidence of pneumocephalus after craniotomy with the patient in the sitting position, and the subsequent development, if any, of tension pneumocephalus and its pathogenesis has yet to be assessed. The present study therefore has a twofold aim: on the one hand, to evaluate the true incidence of pneumocephalus after craniotomy with the patient in the sitting position and, on the other, to discuss the underlying mechanism and the predisposing factors involved in its progression towards tension pneumocephalus.…”