Supraspinatus Tendinopathy in 327 Dogs: A Retrospective Study

Canapp, Sherman O.; Canapp, Debra; Carr, Brittany Jean; Cox, Catherine; Barrett, Jennifer G.

doi:10.18849/ve.v1i3.32

Cited by 16 publications

(20 citation statements)

References 44 publications

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“…8 Supraspinatus tendinopathy is frequently diagnosed in dogs, especially working dogs and dogs used for sport, and cruciate ligament ruptures are common and often bilateral among medium-to large-sized dogs. 9,10 Similar to those in human patients, all of these injuries cause chronic pain and carry a poor prognosis without costly advanced treatments or surgery. These injuries can lead to retirement from work/athletics and possibly euthanasia in veterinary patients.…”

Section: The Clinical Importance Of Tendon and Ligament Bioreactorsmentioning

confidence: 99%

“…These injuries can lead to retirement from work/athletics and possibly euthanasia in veterinary patients. 9,11,12 Tendons and ligaments are indispensable for stability and motion of the musculoskeletal system, but our understanding of the biology of their development and diseases is incomplete. Tendons transmit the force of muscle to bone across a joint, and thereby facilitate movement and joint stabilization.…”

Section: The Clinical Importance Of Tendon and Ligament Bioreactorsmentioning

confidence: 99%

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A brief history of tendon and ligament bioreactors: Impact and future prospects

Dyment

Barrett

Awad

et al. 2020

Journal Orthopaedic Research

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Bioreactors are powerful tools with the potential to model tissue development and disease in vitro. For nearly four decades, bioreactors have been used to create tendon and ligament tissue-engineered constructs in order to define basic mechanisms of cell function, extracellular matrix deposition, tissue organization, injury, and tissue remodeling. This review provides a historical perspective of tendon and ligament bioreactors and their contributions to this advancing field. First, we demonstrate the need for bioreactors to improve understanding of tendon and ligament function and dysfunction. Next, we detail the history and evolution of bioreactor development and design from simple stretching of explants to fabrication and stimulation of two-and three-dimensional constructs. Then, we demonstrate how research using tendon and ligament bioreactors has led to pivotal basic science and tissue-engineering discoveries. Finally, we provide guidance for new basic, applied, and clinical research utilizing these valuable systems, recognizing that fundamental knowledge of cell-cell and cell-matrix interactions combined with appropriate mechanical and chemical stimulation of constructs could ultimately lead to functional tendon and ligament repairs in the coming decades.

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Section: The Clinical Importance Of Tendon and Ligament Bioreactorsmentioning

confidence: 99%

Section: The Clinical Importance Of Tendon and Ligament Bioreactorsmentioning

confidence: 99%

A brief history of tendon and ligament bioreactors: Impact and future prospects

Dyment

Barrett

Awad

et al. 2020

Journal Orthopaedic Research

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show abstract

“…In contrast, diagnostic ultrasound allows for increased ease of acquisition without the need for sedation or anesthesia, and the ability to make contralateral comparisons. An ability to evaluate the contralateral limb may be particularly valuable in dogs with bilateral forelimb lameness, reported in up to 37.6% of dogs with a supraspinatus tendinopathy ( 10 ), making diagnostic ultrasound a convenient modality for both patient diagnosis and an evaluation of patient response to treatment over time.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic Findings in 41 Dogs Treated with Bone Marrow Aspirate Concentrate and Platelet-Rich Plasma for a Supraspinatus Tendinopathy: A Retrospective Study

McDougall¹,

Canapp²,

Canapp³

2018

Front. Vet. Sci.

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Objective To report sonographic findings for dogs with a supraspinatus tendinopathy (ST) treated with an ultrasound-guided intratendinous injection of bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP).Methods Medical records for dogs diagnosed with an ST and treated with a BMAC-PRP injection were reviewed. Data collected included patient signalment, radiographic findings at the time of initial evaluation, and sonographic findings, including cross-sectional area (CSA), fiber pattern, and echogenicity.ResultsOf 70 records reviewed, 41 met the inclusion criteria. Mean CSA of the supraspinatus tendon decreased by 0.06 cm2 between baseline and 45 days post-treatment (p = 0.0025), and 0.09 cm2 between baseline and 90 days post-treatment (p < 0.0001). Analysis of CSA in dogs with a unilateral ST at baseline revealed a difference of 0.08 cm2 between the affected and unaffected tendon at baseline, with the affected tendon measuring larger than the contralateral tendon (p < 0.0001). This difference became statistically insignificant by 45 days after treatment (u1-u0 = 0.04 cm2, p = 0.2855) and remained so 90 days post-treatment (u1-u0 = 0.03 cm2, p = 0.1910). In most cases (90.6%), the fiber pattern and echogenicity was considered improved 90 days post treatment. In a minority of these cases (13.8%) the fiber pattern and echogenicity abnormalities were considered resolved.Conclusions Using qualitative and quantitative sonographic measures, BMAC-PRP was associated with an improvement in supraspinatus tendon size, fiber pattern, and echogenicity. Given the protracted nature of tendon healing, long-term evaluation may reveal continued improvements in chronic structural changes not captured during the current study. Functional studies are required to evaluate the clinical benefits of BMAC-PRP in the treatment of STs in dogs.Clinical significance An ST is a common contributor to forelimb lameness in dogs and remains notoriously difficult to treat. Previous studies have been associated with inconsistent treatment outcomes. In the current study, BMAC-PRP is investigated as a minimally invasive treatment option, revealing positive sonographic results.

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“…Previous reports on the treatment of ST in dogs have included both conservative and surgical management ( 26 – 30 ). While both surgical management and conservative management have been reported for treatment of ST in dogs, up to 55% of surgically treated dogs and in up to 33% of non-surgically treated dogs have persistence or recurrence of lameness ( 26 , 27 ).…”

Section: Introductionmentioning

confidence: 99%

“…While both surgical management and conservative management have been reported for treatment of ST in dogs, up to 55% of surgically treated dogs and in up to 33% of non-surgically treated dogs have persistence or recurrence of lameness ( 26 , 27 ). Regarding conservative medical management, our retrospective study on 327 ST cases in dogs revealed 75% failed to respond to rest and non-steroidal anti-inflammatory drugs and 40% failed to respond to a dedicated rehabilitation therapy program ( 30 ). Recent studies have suggested the potential efficacy of biologic regenerative therapies in humans ( 31 , 32 ).…”

Section: Introductionmentioning

confidence: 99%

The Use of Adipose-Derived Progenitor Cells and Platelet-Rich Plasma Combination for the Treatment of Supraspinatus Tendinopathy in 55 Dogs: A Retrospective Study

Canapp¹,

Canapp²,

Ibrahim³

et al. 2016

Front. Vet. Sci.

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ObjectiveTo report clinical findings and outcomes for 55 dogs with supraspinatus tendinopathy (ST) treated with adipose-derived progenitor cells and platelet-rich plasma (ADPC-PRP) therapy.MethodsMedical records of client-owned dogs diagnosed with ST that were treated with ADPC-PRP combination therapy were reviewed from 2006 to 2013. Data collected included signalment, medical history, limb involvement, prior treatments, physical and orthopedic examination, objective temporospatial gait analysis findings, diagnostic imaging results (radiography, magnetic resonance imaging, musculoskeletal ultrasonography), arthroscopy findings, and outcome.ResultsFollowing ultrasound-guided injection of ADPC-PRP, objective gait analysis was available on 25 of the 55 dogs at 90 days post ADPC-PRP therapy. Following treatment, a significant increase in total pressure index percentage (TPI%) was noted in the injured (treated) forelimb at 90 days post treatment (p = 0.036). At 90 days following treatment, 88% of cases had no significant difference in TPI% of the injured limb to the contralateral limb. The remaining 12% of cases had significantly improved (p = 0.036). Bilateral shoulder diagnostic musculoskeletal ultrasound revealed a significant reduction in tendon size (CSA) in the treated tendon at 90 days following treatment when compared to the initial CSA (p = 0.005). All cases showed significant improvement in fiber pattern of the affected supraspinatus tendon by the ultrasound shoulder pathology rating scale.Clinical RelevanceThese findings suggest that ADPC-PRP therapy should be considered for dogs with ST.

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Supraspinatus Tendinopathy in 327 Dogs: A Retrospective Study

Cited by 16 publications

References 44 publications

A brief history of tendon and ligament bioreactors: Impact and future prospects

A brief history of tendon and ligament bioreactors: Impact and future prospects

Ultrasonographic Findings in 41 Dogs Treated with Bone Marrow Aspirate Concentrate and Platelet-Rich Plasma for a Supraspinatus Tendinopathy: A Retrospective Study

The Use of Adipose-Derived Progenitor Cells and Platelet-Rich Plasma Combination for the Treatment of Supraspinatus Tendinopathy in 55 Dogs: A Retrospective Study

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