Suprasellar Hemangioblastoma on 68Ga-DOTATATE PET/CT

Filizoğlu, Nuh; Özgüven, Salih

doi:10.1097/rlu.0000000000004309

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…The average age of presentation for CNS hemangioblastoma is 33 years. They are most commonly seen in the spinal cord and cerebellum, brainstem, lumbosacral nerve roots, and supratentorial regions 1,6,7. Retinal hemangioblastomas are one of the common tumors of VHL disease, affecting 60% of patients.…”

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confidence: 99%

68Ga-DOTANOC PET/CT in 2 Siblings With Von Hippel–Lindau Disease

G.B.,

Damle,

Reddy K.

et al. 2024

Clin Nucl Med

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Von Hippel–Lindau disease is a rare multisystem disorder that shows autosomal dominant inheritance. It is a cancer syndrome that is characterized by the development of a variety of benign and malignant tumors—CNS hemangioblastomas, retinal angiomas, endolymphatic sac tumors, renal cysts and tumors, pancreatic cysts and tumors, adrenal pheochromocytomas, and epididymal cystadenomas. Here we present the 68Ga-labeled DOTANOC scans of 2 siblings who show an interesting spectrum of findings consistent with Von Hippel–Lindau disease.

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confidence: 99%

68Ga-DOTANOC PET/CT in 2 Siblings With Von Hippel–Lindau Disease

G.B.,

Damle,

Reddy K.

et al. 2024

Clin Nucl Med

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“…However, several sources of false-positive uptake have been characterized in the literature, most commonly in vertebral and other intraosseous hemangiomas 1–4 . False-positive uptake within nodal hemangiomas, 5 anastomosing hemangiomas, 6 as well as a case of suprasellar hemangioblastoma 7 have also been reported. Other sources of false-positive uptake include meningiomas, degenerative bone disease, fractures, reactive nodes, prostatitis, splenosis, and physiologic prominent uptake in the pancreatic uncinate process 8 .…”

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confidence: 99%

False-Positive Uptake in Splenic Hemangioma on 68Ga-DOTATATE PET/CT

et al. 2023

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Somatostatin receptor imaging using 68Ga-DOTATATE PET is widely popular for evaluation of neuroendocrine tumors. 68Ga-DOTATATE PET/CT shows highest physiologic uptake in spleen followed by other organs such as kidneys, adrenal glands, and liver. Hemangiomas, although rare, are the most common primary benign neoplasm of the spleen, composed of endothelial-lined vascular channels. We present a case of 77-year-old man who underwent 68Ga-DOTATATE PET/CT scan for evaluation of pancreatic neuroendocrine tumor and incidentally demonstrated intense radiotracer uptake in splenic hemangiomata.

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“…68 Ga-DOTATATE uptake has been shown to be relatively high in paragangliomas, but variable, with mean SUV max of 81 ± 84 11 . Other neuroaxis tumors including schwannomas and meningiomas demonstrate variable degrees of somatostatin-receptor expression and, consequently, variable 68 Ga-DOTATATE uptake 12–15 . Leveraging the underlying biology of these tumors, molecular imaging of the SSTR with 68 Ga-DOTATATE PET may provide additional information that can be used to discriminate among these entities.…”

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confidence: 99%

68Ga-DOTATATE PET to Characterize Lesions in the Neuroaxis

Hartmann,

Gillman,

Lazor

et al. 2023

Clin Nucl Med

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Aim The differentiation of paragangliomas, schwannomas, meningiomas, and other neuroaxis tumors in the head and neck remains difficult when conventional MRI is inconclusive. This study assesses the utility of 68Ga-DOTATATE PET/CT as an adjunct to hone the diagnosis. Patients and Methods This retrospective study considered 70 neuroaxis lesions in 52 patients with 68Ga-DOTATATE PET/CT examinations; 22 lesions (31%) had pathologic confirmation. Lesions were grouped based on pathological diagnosis and best radiologic diagnosis when pathology was not available. Wilcoxon rank sum tests were used to test for differences in SUVmax among paragangliomas, schwannomas, and meningiomas. Receiver operator characteristic curves were constructed. Results Paragangliomas had a significantly greater 68Ga-DOTATATE uptake (median SUVmax, 62; interquartile range [IQR], 89) than nonparagangliomas. Schwannomas had near-zero 68Ga-DOTATATE uptake (median SUVmax, 2; IQR, 1). Intermediate 68Ga-DOTATATE uptake was seen for meningiomas (median SUVmax, 19; IQR, 6) and other neuroaxis lesions (median SUVmax, 7; IQR, 9). Receiver operator characteristic analysis demonstrated an area under the curve of 0.87 for paragangliomas versus all other lesions and 0.97 for schwannomas versus all other lesions. Conclusions Marked 68Ga-DOTATATE uptake (>50 SUVmax) favors a diagnosis of paraganglioma, although paragangliomas exhibit a wide variability of uptake. Low to moderate level 68Ga-DOTATATE uptake is nonspecific and may represent diverse pathophysiology including paraganglioma, meningioma, and other neuroaxis tumors but essentially excludes schwannomas, which exhibited virtually no uptake.

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Suprasellar Hemangioblastoma on 68Ga-DOTATATE PET/CT

Cited by 5 publications

References 10 publications

68Ga-DOTANOC PET/CT in 2 Siblings With Von Hippel–Lindau Disease

68Ga-DOTANOC PET/CT in 2 Siblings With Von Hippel–Lindau Disease

False-Positive Uptake in Splenic Hemangioma on 68Ga-DOTATATE PET/CT

68Ga-DOTATATE PET to Characterize Lesions in the Neuroaxis

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