Supraorbital neuroma masquerading as local recurrence from a previously excised microcystic adnexal carcinoma

Seaward, James R.; Kalipershad, Sujala; Ross, Gary

doi:10.1016/j.bjps.2009.07.013

Cited by 2 publications

(8 citation statements)

References 9 publications

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“…Patient management is summarized in Table 3. The initial intervention included simple excision in 47 of 93 (51%) patients, with margins reported as negative for carcinoma in 33 of 47 (70%), 2,5,13,21,22,26,33–35,42,44,45,47,52,53,59,60,68 positive in 7 of 47 (15%), 5,11,15,24,38,49 and not documented in 7 of 47 (15%) cases. 17,24,25,27,57,59 Excision with frozen section clearance of margins was performed in 8 of 93 (9%) patients.…”

Section: Resultsmentioning

confidence: 99%

“…Information on the duration of follow-up was available on 64 of 93 patients (69%). 2,3,5,8,9,11–16,18,20–22,24–33,36–51,53–55,57–59,61–69 The average total period of observation from the time of initial presentation to the final documented care was 8 years (median 5, range 0.2–70 years), and the average follow-up after last documented treatment was 3 years (median 2, range 0.2–20 years). Follow-up information was available on 87 of 93 (94%) patients.…”

Section: Resultsmentioning

confidence: 99%

“…Review of the literature identified 92 patients fulfilling the inclusion criteria for this study in addition to our current patient, for a total of 93 patients with MAC. 2,3,5,8,9,11–69 Patient demographics and presenting characteristics are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…4,71,78 MRI generally demonstrates an infiltrative poorly defined lesion with low T2 signal intensity, which enhances following administration of gadolinium. 48,53,71,78 CT scan is useful to highlight bone destruction. 64,71 The initial diagnostic biopsy should be large and deep enough to allow visualization of the architecture of the lesion.…”

Section: Managementmentioning

confidence: 99%

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Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Cheung

Rabinowitz

Tuluc

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To describe a patient with periocular microcystic adnexal carcinoma (MAC) and to review the clinical presentation, systemic work-up, histopathologic features, and outcome of all previously reported periocular MAC. Methods: A major literature review. PubMed/MEDLINE and Google Scholar databases were searched for all well-documented cases of periocular MAC. Results: The final analysis yielded 93 patients with MAC, 48 (52%) females, 39 (42%) males, and 6 with sex not specified (6%) with an average age of 56 years (range 3 days–95 years). Most tumors were localized to the eyebrow (26/93, 28%) and lower eyelid (20/93, 22%). Of patients with known information, MAC most commonly presented as a nodule (37/68, 54%) or plaque (20/68, 29%) with poorly-defined margins (20/51, 39%) and distortion of eyelid margin (13/51, 25%). Orbital involvement at any point of the disease course was seen in 20 of 93 (22%) patients. An accurate histopathologic diagnosis on initial biopsy was made in 25 of 70 (36%) cases. Initial management included surgical excision (47/93, 51%), Mohs micrographic surgery (17/93, 18%), and excision with frozen section control of margins (8/93, 9%). Aggressive or recurrent MAC was managed with multimodal therapies, including adjuvant radiation (10/34, 29%). The average follow-up after the last treatment was 3 years (median 2, range 0.2–20 years). In total, 33 of 86 (38%) tumors recurred, and 6 of 87 (7%) metastasized. Disease-related mortality occurred in 3 of 79 (4%) of patients. Conclusions: Periocular MAC is frequently misdiagnosed on initial biopsy and has a tendency for recurrence and locally aggressive behavior, highlighting the importance of accurate timely diagnosis, and appropriate management.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

See 3 more Smart Citations

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Cheung

Rabinowitz

Tuluc

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Microcystic adnexal carcinoma of the eyelid and orbit: A case report and review of literature

et al. 2023

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Microcystic adnexal carcinoma (MAC), a rare and low-grade malignant skin tumor, is characterized by a high rate of misdiagnosis and a preponderance for local recurrence, but seldom seen nodal or distant metastasis. Although MAC typically occurs almost in the head and neck region, primary eyelid or orbital MAC is very rare. To explore the unique characteristics of the eyelid and orbital MAC, we reviewed the relevant literature. Based on its distinctive anatomical location and the aggressive behavior, eyelid or orbital MAC not only exhibit a high rate of misdiagnosis and local recurrence, but also lead to serious complications such as disfigurement after orbital exenteration, paranasal sinuses or intracranial invasion, even death. Misdiagnosis of MAC commonly result from its rarity and nonspecific clinical and histopathological presentation. To reduce or avoid misdiagnosis, it is important to increase awareness for MAC and obtain a full-thickness biopsy specimen in histopathological analysis. Due to its extensive invasive growth pattern, MAC has a high rate of local recurrence, so complete excision with clear margins and long-term follow-up of patients with MAC are necessary. About those serious complications of the eyelid and orbital MAC, early and accurate diagnosis, complete excision is very important. Moreover, an interprofessional team consisting of ophthalmologist, otolaryngologist, neurologist, dermatologist, pathologist, radiologist is needed to evaluate and treat this disease. In summary, increasing awareness, early and accurate diagnosis, complete excision, long-term follow-up, and a multidisciplinary team is crucial for management of the eyelid and orbital MAC.

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Supraorbital neuroma masquerading as local recurrence from a previously excised microcystic adnexal carcinoma

Cited by 2 publications

References 9 publications

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Microcystic adnexal carcinoma of the eyelid and orbit: A case report and review of literature

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