Supramolekulare Pillar[n]aren‐Aggregate und ihre Anwendungen

Abstract

Makrocyclen sind wichtige Komponenten der supramolekularen Chemie. 2008 wurde eine neue Klasse von Makrocyclen, die so genannten Pillar[n]arene, entdeckt. Die Forschungsaktivitäten im Bereich der Pillar[n]arene haben zur Aufklärung ihrer wichtigen Eigenschaften, wie ihrer Form, Reaktionsmechanismen, Wirt‐Gast‐Eigenschaften und vielseitigen Funktionalität, beigetragen, wodurch die Entwicklung der Pillar[n]aren‐Chemie und die Anwendung von Pillar[n]arenen in verschiedenen Gebieten vorangetrieben wurden. Dieser Kurzaufsatz beschreibt, wie supramolekulare Pillar[n]aren‐Aggregate für die supramolekulare Gelbildung, chemische Reaktionen, Lichtsammelsysteme, Wirkstofftransportsysteme, biochemische Anwendungen, Trenn‐ und Speichermaterialien sowie die Oberflächenchemie verwendet werden können.

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

“…By inhibiting lactate metabolism and generating toxic reactants, HCLP NPs can suppress tumor growth and metastasis while enhancing therapeutic efficacy. The research group led by Liu synthesized pillar [6]-arene-based nanoparticles, known as GOx@T-NPs [58,59]. These nanoparticles are associated with the Fenton reaction and have been applied for the treatment of malignant tumors [60].…”

Towards Universal Stimuli-Responsive Drug Delivery Systems: Pillar[5]arenes Synthesis and Self-Assembly into Nanocontainers with Tetrazole Polymers

“…groups [42][43][44]. Analysis of the literature has shown that four main pillar [5]arenes 1-4 (Figure 1) are the most studied as components of self-assembling systems [48][49][50][51][52][53]. The presence of acidic protons in the tetrazole fragments of PVT and PVTE (Figure 1) excludes the use of carboxylate groups (compounds 1, 2 in Figure 1) in the pillar [5]arene structure for further study of the interaction with polymers.…”

Nanoparticles based on the zwitterionic pillar[5]arene and Ag+: synthesis, self-assembly and cytotoxicity in the human lung cancer cell line A549

“…The DLS method is a more sensitive method and captures the entire range of particles in solution, and the DOSY NMR spectroscopy method is less sensitive and captures only small particles formed during the association process [43]. Previously, the ability of pillar [5]arenes to interact with various anions [11] was shown. In this regard, to assess the possible interfering effect on the formation of 3/Ag + associates, the anions NO 3 − , СH 3 COO − , and SO 4 2− present in the solution were studied, and their possible competition with Ag + for the pillar [5]arene 3 was also studied.…”

“…In order to reduce the toxicity of Ag + ions, multicore complexes prepared on the basis of macrocyclic ligands [9][10][11][12][13] and silver ions are of greatest interest. The ability of macrocyclic systems to form supramolecular associates, due to noncovalent interactions with Ag + , can reduce toxicity and preserve the biomedical properties of the resulting nanoscale particles that do not contain Ag-Ag bonds [14].…”