Supramolecular β-Cyclodextrin/Multi-walled Carbon Nanotube Paste Electrode for Amperometric Detection of Naproxen

Abstract

The electrochemical behavior of Naproxen (NAP) at a novel β-Cyclodextrin/Multi-walled carbon nanotube paste electrode (β-CD/CNTPE) was investigated. The study was carried out by using cyclic voltammetry (CV) and chronoamperometry (CA) techniques. The overall analysis involved an accumulation step, in which the NAP was adsorbed onto β-cyclodextrin, followed by amperometric quantification of NAP. Various parameters such as amount of β-CD, accumulation time, pH and scan rate were optimized. The proposed electrode showed a good response toward NAP determination. The calibration plot for NAP determination is linear in the range of 0.4 to 23 μg mL−1 under optimum experimental conditions. The limit of detection based on 3sb/b was found to be 0.37 μg mL−1. The proposed electrode (β-CD/CNTPE) presented good repeatability, evaluated in term of relative standard deviation (2.7%) for five replicate measurement. Also, the analytical applicability of the proposed electrode was tested through the analysis of several pharmaceutical preparations.

Self-Assembled Hydrogels Based on Poly-Cyclodextrin and Poly-Azobenzene Compounds and Applications for Highly Efficient Removal of Bisphenol A and Methylene Blue

“…Due to moderate internal diameter, low price, and negligible toxicity, β-cyclodextrin-based self-assembled materials have been intensively investigated in many fields, such as controlled release drug carriers, self-healing hydrogels, and electrochemical sensors. 2−4 However, native cyclodextrins are unable to incorporate certain hydrophilic compounds or large molecules. To overcome these limitations and extend the inclusion capacity, the syntheses of cyclodextrin polymers are necessary.…”

“…Cyclodextrins (CDs) are macrocyclic oligosaccharides with the special structure of hydrophobic interior cavity and hydrophilic exterior ring. 1 β-Cyclodextrin is composed of seven repeated monomers of glucopyranose units linked by α- (1,4) glycosidic linkages. Due to moderate internal diameter, low price, and negligible toxicity, β-cyclodextrin-based self-assembled materials have been intensively investigated in many fields, such as controlled release drug carriers, self-healing hydrogels, and electrochemical sensors.…”

“…β-Cyclodextrin is composed of seven repeated monomers of glucopyranose units linked by α-(1,4) glycosidic linkages. Due to moderate internal diameter, low price, and negligible toxicity, β-cyclodextrin-based self-assembled materials have been intensively investigated in many fields, such as controlled release drug carriers, self-healing hydrogels, and electrochemical sensors. − However, native cyclodextrins are unable to incorporate certain hydrophilic compounds or large molecules. To overcome these limitations and extend the inclusion capacity, the syntheses of cyclodextrin polymers are necessary. , Cyclodextrin polymers could be prepared by reacting cyclodextrins with cross-linking agents, such as epichlorohydrin, carbonyl compounds (e.g., diphenyl carbonate, dimethyl carbonate, carbonyldiimidazole), and organic dianhydrides (e.g., pyromelitic anhydride). − In contrast to CDs, cyclodextrin polymers (poly-CD) exhibited higher efficiency to accommodate high-weight molecules and demonstrated higher stability constants since all of the cyclodextrin units co-operatively participated in the formation process of inclusion complexes. − …”

Electrochemical Derivatization of Acetaminophen for Indirect Determination of Eflornithine Using β‐CD Modified Glassy Carbon Electrode

“…To this purpose, electrochemical behavior of APAP (1) was studied in the absence and presence of DFMO (2). In addition, due to host-guest property of β-cyclodextrin especially for acetaminophen [37][38][39][40], we designed an electrochemical sensor based on β-Cyclodextrin (β-CD) modified glassy carbon electrode capable of improving sensitivity, linearity and limit of detection (LOD) of DFMO (2) in comparison with bare GCE.…”

Enhanced Electrochemical Sensing Based on Perylenetetracarboxylic Acid Functionalized Carbon Nanohorns Hybrids Modified Electrode

“…Consequently, the chemical functionalization of CNHs is an essential way to introduce a variety of functional units onto their external surface to enhance the dispersibility and handling of CNHs in common solvents. [13][14][15][16] Presently, there are two main pathways for the chemical modification of CNHs, namely (i) the covalent attachment and (ii) the noncovalent assembly. 8,17 Typically, for the covalent functionalization, the oxidation of the conical ends of CHNs under concentrated acidic conditions is used to introduce oxygenated units, mainly in the form of carboxylic group, to form stable bond with other organic moieties onto the outer skeleton of CNHs.…”