Supramolecular soft biomaterials for biomedical applications

Ye, Enyi; Chee, Pei Lin; Prasad, Ankshita; Fang, Xiaotian; Owh, Cally; Yeo, Valerie Jing Jing; Loh, Xian Jun

doi:10.1016/j.mattod.2014.04.004

Cited by 106 publications

(64 citation statements)

References 52 publications

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“…Moreover, these injectable materials can be engineered to display tunable biodegradation under different environmental conditions depending on the chemistry used to form the cross-links. 9,11,12 However, injectable hydrogels are often limited by a relatively low elastic modulus, [13][14][15][16] limiting their utility in applications demanding at least a degree of mechanical strength (e.g. engineering of stiffer tissues such as cartilage, 17 implantation in high-shear environments, 18 or spinal applications 19 ).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Mechanical Properties in Cellulose Nanocrystal–Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking

2016

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While injectable hydrogels have several advantages in the context of biomedical use, their generally weak mechanical properties often limit their applications. Herein we describe in situgelling nanocomposite hydrogels based on poly(oligoethylene glycol methacrylate) (POEGMA) and rigid rod-like cellulose nanocrystals (CNCs) that can overcome this challenge. By physically incorporating CNCs into hydrazone cross-linked POEGMA hydrogels, macroscopic properties including gelation rate, swelling kinetics, mechanical properties, and hydrogel stability can be readily tailored. Strong adsorption of aldehyde and hydrazide modified POEGMA precursor polymers onto the surface of CNCs promotes uniform dispersion of CNCs within the hydrogel, imparts physical cross-links throughout the network, and significantly improves mechanical strength overall, as demonstrated by quartz crystal microbalance gravimetry and rheometry.When POEGMA hydrogels containing mixtures of long and short ethylene oxide side chain precursor polymers were prepared, transmission electron microscopy reveals that phase segregation occurs with CNCs hypothesized to preferentially locate within the stronger adsorbing short side chain polymer domains. Incorporating as little as 5 wt % CNCs results in dramatic enhancements in mechanical properties (up to 35-fold increases in storage modulus) coupled with faster gelation rates, decreased swelling ratios, and increased stability versus hydrolysis. Furthermore, cell viability can be maintained within 3D culture using these hydrogels independent of the CNC content. These properties collectively make POEGMA-CNC

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Section: Introductionmentioning

confidence: 99%

Enhanced Mechanical Properties in Cellulose Nanocrystal–Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking

2016

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“…[18][19][20][21] Smaller homologues of the CB[n] family (i.e. CB [5], CB [6] and CB [7]) are capable of binding single guests (typically cationic amines, metals, imidazolium ions and small molecule drugs). [22][23][24][25] In contrast to the smaller CB[n] homologues, CB [8] has a larger cavity volume (479 Å 3 ) 26,27 capable of simultaneously accommodating two planar and hydrophobic guests in a π-π-stacked geometry.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Supramolecular Recognition of Multivalent Peptide–Polysaccharide Conjugates by Cucurbit[8]uril in Hydrogel Formation

et al. 2015

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Supramolecular hydrogels were fabricated by physically cross-linking phenylalanine functionalized polysaccharides with cucurbit[8]uril in water. We report a facile 2-step method of functionalization of the polysaccharides hyaluronic acid (HA), carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), and guar with the dipeptide Phe-Cys. Addition of cucurbit[8]uril to the functional polysaccharides initiated physical cross-linking on account of strong 1:2 "homoternary" complexes with the pendant Phe residues. In particular, HA and CMC based soft hydrogels displayed impressive viscoelastic behavior which was characterized using rheology, demonstrating accessibility to an array of material properties which would find broad applicability in many fields.

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“…It is well known that the surface chemistry of a nanoparticle determines its pharmacokinetics, biodistribution and clearance pathway, and PEGylation is required to avoid recognition by the reticuloendothelial system and extend circulation time . Sustained delivery with viscous formulations such as supramolecular hydrogels or thermogels could also be useful for prolonged release of these nanomotors in the organ.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Anisotropic Particles: Toward Remotely Actuated Applications

Teo

Young

Loh

2016

Part & Part Syst Charact

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The latest breakthroughs in the synthetic preparation of nanomaterials have led to an expanding library of novel, complex and shape controlled structures with unique characteristics. Anisotropic Janus particles (JPs) are asymmetrical and are able to endow diverse chemical and physical characteristics with directionality within a single particle. They are typically distributed into three classes, viz polymeric, inorganic and polymeric‐inorganic and is made in a variation of morphologies including spherical, mushroom, snowman shaped, rod or cylindrical. Herein, we focus on JPs with a magnetic component, with emphasis on their fabrication, unique characteristics and recent applications.

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Supramolecular soft biomaterials for biomedical applications

Cited by 106 publications

References 52 publications

Enhanced Mechanical Properties in Cellulose Nanocrystal–Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking

Enhanced Mechanical Properties in Cellulose Nanocrystal–Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking

Preparation and Supramolecular Recognition of Multivalent Peptide–Polysaccharide Conjugates by Cucurbit[8]uril in Hydrogel Formation

Magnetic Anisotropic Particles: Toward Remotely Actuated Applications

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