Supramolecular self-organization in constitutional hybrid materials

Abstract

European Science Foundation EURYIWe present in this paper a new strategy to transcribe the supramolecular dynamic self-organization of the G-quadruplex and ureidocrown ether ion channel-type columnar architectures in constitutional hybrids. In particular, the use of a "dynamic reversible hydrophobic interface'' can render the emerging hybrid mesophases self-adaptive. The reversible hydrophobic interactions allow both supramolecular and inorganic silica components to mutually (synergistically) adapt their spatial constitution during simultaneous (collective) formation of micrometric self-organized hybrid domains. More generally, applying such consideration to materials, leads to the definition of constitutional hybrid materials, in which organic (supramolecular)/inorganic domains are reversibly connected. This might provide new insights into the features that control the design of functional materials

Squalyl Crown Ether Self‐Assembled Conjugates: An Example of Highly Selective Artificial K+ Channels

“…[5][6][7][8][9] In the last decade, we proposed an ew path towards elf-organization of various systems containing bilayer-compatible lipophilic tails and suitable macrocyclic groups for cation recognitiont hat can selforganize through urea H-bonding into continual ribbon ionchannel superstructures. [14][15][16] Their self-organization in liquid, solid, and lipid bilayer membrane phases provided evidence for ap ossible hybrid-carrier and channel-transport mechanism. [15,16] More precisely,w eu se monomers that are potential carrierlike transporters able to self-assemble into oligomeric aggregates that are potentialm embrane-spanning channel-like superstructures.…”

“…[14][15][16] Their self-organization in liquid, solid, and lipid bilayer membrane phases provided evidence for ap ossible hybrid-carrier and channel-transport mechanism. [15,16] More precisely,w eu se monomers that are potential carrierlike transporters able to self-assemble into oligomeric aggregates that are potentialm embrane-spanning channel-like superstructures. In ap hospholipidic bilayer membrane, they form channels at low concentration and prefer disruption over regularb ehavior.…”

Real‐Time Optical Detection of Stabilized Artificial G‐Quadruplexes Under Confined Conditions

“…[6] Liposomes, [7] surfaces, [8] dynamers, [9] hybrid materials, [10,11] and mesoporous silica [12] have been used as scaffolding matrices to stabilize and to orient the anisotropic directional G-mesophases. They are reminiscent of other supramolecular pore-confined systems [13,14] or DNA-modified surfaces.…”

Dynamic Nanoplatforms in Biosensor and Membrane Constitutional Systems

“…The extension of the constitutional chemistry approach to nanoplatforms would be able to compete at multiple length scales within nanoscopic networks and to display variations in their sizes and functionality. Furthermore, we can relate this behaviour to purely synthetic compositions such as the "Dynamic interactive systems" [11][12][13] characterized by their aptitude to organize (self-control) macroscopically their distribution in response to external stimuli in coupled equilibria. This growing multidisciplinary field of nanobiotechnology could have important contributions to make to the future of medicine [14], part of which, the consideration of molecular recognition events at the cell membrane surface as information transfer, could have important implications when applied to pharmaceutical development [15,16].…”